Fibroblast growth factors (FGFs) can be classified as secretory (FGFI-10 and FGF15-23) or intracellular non-secretory forms (FGF 11-14). Secretory forms of FGF and their receptors are best known for their regulatory r...Fibroblast growth factors (FGFs) can be classified as secretory (FGFI-10 and FGF15-23) or intracellular non-secretory forms (FGF 11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation and morphogenesis in the early stages of neural development. However, the functions of intracellular FGFs remain to be ex- plored. FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neu- rons. FGF13 is expressed in primary sensory neurons, and is colocalized with sodium channels at the nodes of Ranvier along the myelinated afferent fibers. FGF13 is also expressed in cerebral cortical neurons during the late developmental stage. A re- cent study showed that FGFI3 is a microtubule-stabilizing protein required for regulating the neuronal development in the cerebral cortex. Thus, non-secretory forms of FGF appear to have important roles in the brain, and it would be interesting to further investigate the functions of intracellular FGFs in the nervous system and in neural diseases.展开更多
基金supported by the National Natural Science Foundation of China (Grant Nos. 31130066 and 30630029)National Basic Research Program of China (Grant Nos. 2011CBA00400 and 2009CB522005)Strategic Priority Research Program (B) of Chinese Academy of Sciences(Grant No. XDB02010200)
文摘Fibroblast growth factors (FGFs) can be classified as secretory (FGFI-10 and FGF15-23) or intracellular non-secretory forms (FGF 11-14). Secretory forms of FGF and their receptors are best known for their regulatory roles in cell growth, differentiation and morphogenesis in the early stages of neural development. However, the functions of intracellular FGFs remain to be ex- plored. FGF12 and FGF14 are found to interact with voltage-gated sodium channels, and regulate the channel activity in neu- rons. FGF13 is expressed in primary sensory neurons, and is colocalized with sodium channels at the nodes of Ranvier along the myelinated afferent fibers. FGF13 is also expressed in cerebral cortical neurons during the late developmental stage. A re- cent study showed that FGFI3 is a microtubule-stabilizing protein required for regulating the neuronal development in the cerebral cortex. Thus, non-secretory forms of FGF appear to have important roles in the brain, and it would be interesting to further investigate the functions of intracellular FGFs in the nervous system and in neural diseases.
