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Heteroatom dopant strategy triggered high-potential plateau to non-graphitized carbon with highly disordered microstructure for high-performance sodium ion storage
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作者 Peilin Zhang Chen Huang +6 位作者 Mingzhen Xiu Siyu zhu Weiwei Wang bo zhu Likang Qin Yizhong Huang Luyang Chen 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2023年第4期192-200,共9页
Non-graphitized carbon(NGC)has been extensively utilized as carbonaceous anode in sodium-ion batteries(SIBs).However,more optimization to achieve competitive capacity and stability is still challenging for SIBs.In the... Non-graphitized carbon(NGC)has been extensively utilized as carbonaceous anode in sodium-ion batteries(SIBs).However,more optimization to achieve competitive capacity and stability is still challenging for SIBs.In the study,the dopant strategy is utilized to construct nitrogen/sulfur-doped non-graphitized carbon(N-NGC or S-NGC)shell decorated on three-dimensional graphene foam(GF)as a self-support electrode.The highly disordered microstructures of heteroatom doped carbons are produced by applying a low-temperature pyrolysis treatment to precursors containing nitrogen and sulfur.The DFT calculations of Na-ion adsorption energies at diverse heteroatom sites show marginal-S,pyrrolic N and pyridinic N with more intensive Na-ion adsorption ability than middle-S,C=O and pristine carbon.The N-NGC with dominant small graphitic regions delivers adsorption ability to Na-ion,while the S-NGC with significant single carbon lattice stripes demonstrates redox reaction with Na-ion.Evidently,in comparison with only adsorption-driven slope regions at high potential for N-NGC,the redox reaction-generated potentialplateau enables non-graphitized S-NGC superior discharge/charge capacity and cycle-stability in the slope region.This work could provide deep insight into the rational design of non-graphitized carbon with rich microstructure and composition. 展开更多
关键词 Non-graphitized carbon Highly disordered microstructure Heteroatom dopant Adsorption Redox reaction
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An Imbalanced Data Classification Method Based on Hybrid Resampling and Fine Cost Sensitive Support Vector Machine 被引量:1
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作者 bo zhu Xiaona Jing +1 位作者 Lan Qiu Runbo Li 《Computers, Materials & Continua》 SCIE EI 2024年第6期3977-3999,共23页
When building a classification model,the scenario where the samples of one class are significantly more than those of the other class is called data imbalance.Data imbalance causes the trained classification model to ... When building a classification model,the scenario where the samples of one class are significantly more than those of the other class is called data imbalance.Data imbalance causes the trained classification model to be in favor of the majority class(usually defined as the negative class),which may do harm to the accuracy of the minority class(usually defined as the positive class),and then lead to poor overall performance of the model.A method called MSHR-FCSSVM for solving imbalanced data classification is proposed in this article,which is based on a new hybrid resampling approach(MSHR)and a new fine cost-sensitive support vector machine(CS-SVM)classifier(FCSSVM).The MSHR measures the separability of each negative sample through its Silhouette value calculated by Mahalanobis distance between samples,based on which,the so-called pseudo-negative samples are screened out to generate new positive samples(over-sampling step)through linear interpolation and are deleted finally(under-sampling step).This approach replaces pseudo-negative samples with generated new positive samples one by one to clear up the inter-class overlap on the borderline,without changing the overall scale of the dataset.The FCSSVM is an improved version of the traditional CS-SVM.It considers influences of both the imbalance of sample number and the class distribution on classification simultaneously,and through finely tuning the class cost weights by using the efficient optimization algorithm based on the physical phenomenon of rime-ice(RIME)algorithm with cross-validation accuracy as the fitness function to accurately adjust the classification borderline.To verify the effectiveness of the proposed method,a series of experiments are carried out based on 20 imbalanced datasets including both mildly and extremely imbalanced datasets.The experimental results show that the MSHR-FCSSVM method performs better than the methods for comparison in most cases,and both the MSHR and the FCSSVM played significant roles. 展开更多
关键词 Imbalanced data classification Silhouette value Mahalanobis distance RIME algorithm CS-SVM
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Network pharmacology and subsequent experimental validation reveal the synergistic myocardial protection mechanism of Salvia miltiorrhiza Bge.and Carthamus tinctorius L. 被引量:1
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作者 Linying Zhong Ling Dong +7 位作者 Jing Sun Jie Yang Zhiying Yu Ping He bo zhu Yuxin zhu Siyuan Li Wenjuan Xu 《Journal of Traditional Chinese Medical Sciences》 CAS 2024年第1期44-54,共11页
Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(S.miltiorrhiza,Dan Shen)and C.tinctorius L.(C.tinctorius,Hong Hua)as an herb pair through network pharmacology and su... Objective:To reveal the molecular mechanism underlying the compatibility of Salvia miltiorrhiza Bge(S.miltiorrhiza,Dan Shen)and C.tinctorius L.(C.tinctorius,Hong Hua)as an herb pair through network pharmacology and subsequent experimental validation.Methods:Network pharmacology was applied to construct an active ingredient-efficacy target-disease protein network to reveal the unique regulation pattern of s.miltiorrhiza and C.tinctorius as herb pair.Molecular docking was used to verify the binding of the components of these herbs and their potential targets.An H9c2 glucose hypoxia model was used to evaluate the efficacy of the components and their synergistic effects,which were evaluated using the combination index.Western blot was performed to detect the protein expression of these targets.Results:Network pharmacology analysis revealed 5 pathways and 8 core targets of s.miltiorrhiza and C.tinctorius in myocardial protection.Five of the core targets were enriched in the hypoxia-inducible factor-1(HIF-1)signaling pathway.S.miltiorrhiza-C.tinctorius achieved vascular tone mainly by regulating the target genes of the HIF-1 pathway.As an upstream gene of the HIF-1 pathway,STAT3 can be activated by the active ingredients cryptotanshinone(Ctan),salvianolic acid B(Sal.B),and myricetin(Myric).Cell experiments revealed that Myric,Sal.B,and Ctan also exhibited synergistic myocardial protective activity.Molecular docking verified the strong binding of Myric,Sal.B,and Ctan to STAT3.Western blot further showed that the active ingredients synergistically upregulated the protein expressionof STAT3.Conclusion:The pharmacodynamic transmission analysis revealed that the active ingredients of S.miltiorrhiza and C.tinctorius can synergistically resist ischemia through various targets and pathways.This study provides a methodological reference for interpreting traditional Chinese medicine compatibility. 展开更多
关键词 S.miltiorrhiza-C.tinctorius herb pair Compatibilitymechanism Networkpharmacology Multipletargeteffect Myocardial protection
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Distribution and Formation Causes of PM_(2.5) and O_(3) Double High Pollution Events in China during 2013–20
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作者 Zhixuan TONG Yingying YAN +6 位作者 Shaofei KONG Jintai LIN Nan CHEN bo zhu Jing MA Tianliang ZHAO Shihua QI 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第6期1235-1250,I0004-I0021,共34页
Fine particulate matter(PM_(2.5))and ozone(O_(3))double high pollution(DHP)events have occurred frequently over China in recent years,but their causes are not completely clear.In this study,the spatiotemporal distribu... Fine particulate matter(PM_(2.5))and ozone(O_(3))double high pollution(DHP)events have occurred frequently over China in recent years,but their causes are not completely clear.In this study,the spatiotemporal distribution of DHP events in China during 2013–20 is analyzed.The synoptic types affecting DHP events are identified with the Lamb–Jenkinson circulation classification method.The meteorological and chemical causes of DHP events controlled by the main synoptic types are further investigated.Results show that DHP events(1655 in total for China during 2013–20)mainly occur over the North China Plain,Yangtze River Delta,Pearl River Delta,Sichuan Basin,and Central China.The occurrence frequency increases by 5.1%during 2013–15,and then decreases by 56.1%during 2015–20.The main circulation types of DHP events are“cyclone”and“anticyclone”,accounting for over 40%of all DHP events over five main polluted regions in China,followed by southerly or easterly flat airflow types,like“southeast”,“southwest”,and“east”.Compared with non-DHP events,DHP events are characterized by static or weak wind,high temperature(20.9℃ versus 23.1℃)and low humidity(70.0%versus 64.9%).The diurnal cycles of meteorological conditions cause PM_(2.5)(0300–1200 LST,Local Standard Time=UTC+8 hours)and O_(3)(1500–2100 LST)to exceed the national standards at different periods of the DHP day.Three pollutant conversion indices further indicate the rapid secondary conversions during DHP events,and thus the concentrations of NO_(2),SO_(2) and volatile organic compounds decrease by 13.1%,4.7%and 4.4%,respectively.The results of this study can be informative for future decisions on the management of DHP events. 展开更多
关键词 double high pollution events PM_(2.5) OZONE spatiotemporal distribution meteorological causes chemical composition characteristics
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The heterogeneity of tumor-associated macrophages and strategies to target it
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作者 HAO LV bo zhu DEGAO CHEN 《BIOCELL》 SCIE 2024年第3期363-378,共16页
Tumor-associated macrophages(TAMs)are emerging as targets for tumor therapy because of their primary role in promoting tumor progression.Several studies have been conducted to target TAMs by reducing their infiltratio... Tumor-associated macrophages(TAMs)are emerging as targets for tumor therapy because of their primary role in promoting tumor progression.Several studies have been conducted to target TAMs by reducing their infiltration,depleting their numbers,and reversing their phenotypes to suppress tumor progression,leading to the development of drugs in preclinical and clinical trials.However,the heterogeneous characteristics of TAMs,including their ontogenetic and functional heterogeneity,limit their targeting.Therefore,in-depth exploration of the heterogeneity of TAMs,combined with immune checkpoint therapy or other therapeutic modalities could improve the efficiency of tumor treatment.This review focuses on the heterogeneous ontogeny and function of TAMs,as well as the current development of tumor therapies targeting TAMs and combination strategies. 展开更多
关键词 Tumor-associated macrophages Tissue-resident macrophages HETEROGENEITY Immune checkpoint therapy
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Ultrasound-Guided Continuous Thoracic Paravertebral Block Improves Patientʼs Quality of Recovery After Open Hepatectomy: A Randomized, Double-Blind, Placebo-Controlled Trial 被引量:5
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作者 Xulei Cui Nan Xu +7 位作者 Zhiyong Zhang bo zhu Yuelun Zhang Yongchang Zheng Shunda Du Yilei Mao Xinting Sang Yuguang Huang 《Chinese Medical Sciences Journal》 CAS CSCD 2022年第1期15-22,共8页
Background Ultrasound-guided continuous thoracic paravertebral block can provide pain-relieving and opioid-sparing effects in patients receiving open hepatectomy.We hypothesize that these effects may improve the quali... Background Ultrasound-guided continuous thoracic paravertebral block can provide pain-relieving and opioid-sparing effects in patients receiving open hepatectomy.We hypothesize that these effects may improve the quality of recovery(QoR)after open hepatectomy.Methods Seventy-six patients undergoing open hepatectomy were randomized to receive a continuous thoracic paravertebral block with ropivacaine(CTPVB group)or normal saline(control group).All patients received patient-controlled intravenous analgesia with morphine postoperatively for 48 hours.The primary outcome was the global Chinese 15-item Quality of Recovery score on postoperative day 7,which was statistically analyzed using Student’s t-test.Results Thirty-six patients in the CTPVB group and 37 in the control group completed the study.Compared to the control group,the CTPVB group had significantly increased global Chinese 15-item Quality of Recovery scores(133.14±12.97 vs.122.62±14.89,P=0.002)on postoperative day 7.Postoperative pain scores and cumulative morphine consumption were significantly lower for up to 8 and 48 hours(P<0.05;P=0.002),respectively,in the CTPVB group.Conclusion Perioperative CTPVB markably promotes patient’s QoR after open hepatectomy with a profound analgesic effect in the early postoperative period. 展开更多
关键词 thoracic paravertebral block HEPATECTOMY quality of recovery ROPIVACAINE
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Study of Thermal Radiation Properties of Pyrolytic Carbon Protective Coatings for Monocrystalline Silicon Furnace
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作者 Wei-Wei Cao bo zhu +3 位作者 Wei Zhao Yong-Wei Wang Yang Chen Xi-Hai Wang 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2013年第4期36-40,共5页
The thermal radiation properties of pyrolytic carbon(PyC)protective coatings for monocrystalline silicon furnace prepared by different processes were tested.The changes of normal emissivity of carbon materials caused ... The thermal radiation properties of pyrolytic carbon(PyC)protective coatings for monocrystalline silicon furnace prepared by different processes were tested.The changes of normal emissivity of carbon materials caused by PyC protective coatings were discussed,and the influence of phase structure and surface appearance on the thermal radiation properties was investigated.The results show that the thermal radiation properties of PyC protective coatings with the wave band of 5-25μm are better than C/C substrate,further,normal spectral emissivity of CVD PyC coating remains basically at 0.85-0.90,and the normal total emissivity can reach0.89,which shows high thermal radiation performance.For resin PyC coating and CVD PyC coating,the degree of graphitization are 44.53%and 16.28%respectively,and the R value of Raman spectrum are 0.964and 1.384 respectively.Relatively disorder graphite structure of the latter causes various vibration modes,and the spectral emissivity is better,so the thermal radiation property of CVD PyC coating is excellent.A lot of spherical particles exists on the surface of the CVD PyC coating,and the more interface and spacing of particles reduce the number of particles per unit volume.Therefore,the scattering of thermal radiation is strongly strengthened,and the spectral emissivity is higher. 展开更多
关键词 Monocrystalline silicon furnace PyC protective coating Normal spectral emissivity Normal total emissivity Graphite structure
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The eQTL colocalization and transcriptome‑wide association study identify potentially causal genes responsible for economic traits in Simmental beef cattle
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作者 Wentao Cai Yapeng Zhang +9 位作者 Tianpeng Chang Zezhao Wang bo zhu Yan Chen Xue Gao Lingyang Xu Lupei Zhang Huijiang Gao Jiuzhou Song Junya Li 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2023年第5期1909-1925,共17页
Background A detailed understanding of genetic variants that affect beef merit helps maximize the efficiency of breeding for improved production merit in beef cattle.To prioritize the putative variants and genes,we ra... Background A detailed understanding of genetic variants that affect beef merit helps maximize the efficiency of breeding for improved production merit in beef cattle.To prioritize the putative variants and genes,we ran a com-prehensive genome-wide association studies(GWAS)analysis for 21 agronomic traits using imputed whole-genome variants in Simmental beef cattle.Then,we applied expression quantitative trait loci(eQTL)mapping between the genotype variants and transcriptome of three tissues(longissimus dorsi muscle,backfat,and liver)in 120 cattle.Results We identified 1,580 association signals for 21 beef agronomic traits using GWAS.We then illuminated 854,498 cis-eQTLs for 6,017 genes and 46,970 trans-eQTLs for 1,903 genes in three tissues and built a synergistic network by integrating transcriptomics with agronomic traits.These cis-eQTLs were preferentially close to the transcription start site and enriched in functional regulatory regions.We observed an average of 43.5%improvement in cis-eQTL discovery using multi-tissue eQTL mapping.Fine-mapping analysis revealed that 111,192,and 194 variants were most likely to be causative to regulate gene expression in backfat,liver,and muscle,respectively.The transcriptome-wide association studies identified 722 genes significantly associated with 11 agronomic traits.Via the colocalization and Mendelian randomization analyses,we found that eQTLs of several genes were associated with the GWAS signals of agronomic traits in three tissues,which included genes,such as NADSYN1,NDUFS3,LTF and KIFC2 in liver,GRAMD1C,TMTC2 and ZNF613 in backfat,as well as TIGAR,NDUFS3 and L3HYPDH in muscle that could serve as the candidate genes for economic traits.Conclusions The extensive atlas of GWAS,eQTL,fine-mapping,and transcriptome-wide association studies aid in the suggestion of potentially functional variants and genes in cattle agronomic traits and will be an invaluable source for genomics and breeding in beef cattle. 展开更多
关键词 Cattle COLOCALIZATION eQTL mapping GWAS TWAS
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A symplectic finite element method based on Galerkin discretization for solving linear systems
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作者 Zhiping QIU Zhao WANG bo zhu 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI CSCD 2023年第8期1305-1316,共12页
We propose a novel symplectic finite element method to solve the structural dynamic responses of linear elastic systems.For the dynamic responses of continuous medium structures,the traditional numerical algorithm is ... We propose a novel symplectic finite element method to solve the structural dynamic responses of linear elastic systems.For the dynamic responses of continuous medium structures,the traditional numerical algorithm is the dissipative algorithm and cannot maintain long-term energy conservation.Thus,a symplectic finite element method with energy conservation is constructed in this paper.A linear elastic system can be discretized into multiple elements,and a Hamiltonian system of each element can be constructed.The single element is discretized by the Galerkin method,and then the Hamiltonian system is constructed into the Birkhoffian system.Finally,all the elements are combined to obtain the vibration equation of the continuous system and solved by the symplectic difference scheme.Through the numerical experiments of the vibration response of the Bernoulli-Euler beam and composite plate,it is found that the vibration response solution and energy obtained with the algorithm are superior to those of the Runge-Kutta algorithm.The results show that the symplectic finite element method can keep energy conservation for a long time and has higher stability in solving the dynamic responses of linear elastic systems. 展开更多
关键词 Galerkin finite element method linear system structural dynamic response symplectic difference scheme
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Mechanism and effects of extramedullary hematopoiesis on anti-tumor immunity
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作者 Zefang Chen Xinyu Cheng +3 位作者 Li Yang Xiaoming Cheng bo zhu Haixia Long 《Cancer Biology & Medicine》 SCIE CAS CSCD 2023年第7期477-482,共6页
Cancer immunotherapy is a preferred strategy for boosting anti-tumor immunity to eliminate malignant cells and is considered a major breakthrough in the field of cancer treatment however,immunosuppressive cells in the... Cancer immunotherapy is a preferred strategy for boosting anti-tumor immunity to eliminate malignant cells and is considered a major breakthrough in the field of cancer treatment however,immunosuppressive cells in the tumor microenvironment(TME)pose a major obstacle to the efficacy of immunotherapy.Myeloid cells,such as tumor-a ssociated macrophages(TAMs)and myeloid-derived suppressor cells(MDSCs). 展开更多
关键词 IMMUNITY IMMUNOTHERAPY CANCER
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A Novel Multi-Granularity Flexible-Grid Switching Optical-Node Architecture
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作者 Zhenfang Huang bo zhu +5 位作者 Mingchen zhu Mengyue Jiang Xinting Song Jiawei Zhao Zheng Wang Fangren Hu 《China Communications》 SCIE CSCD 2023年第1期209-217,共9页
A novel multi-granularity flexible-grid switching optical-node architecture is proposed in this paper.In our system,the photonic lanterns are used as mode division multiplexing/demultiplexing(MD-Mux/MD-Demux)for selec... A novel multi-granularity flexible-grid switching optical-node architecture is proposed in this paper.In our system,the photonic lanterns are used as mode division multiplexing/demultiplexing(MD-Mux/MD-Demux)for selecting mode.The wavelength division multiplexer/demultiplexer(WDMux/WD-Demux)and the fiber bragg gratings(FBGs)are used to select wavelength channels with the various grid.The experimental results show that the transmission bandwidth covers the C+L band,the average transmission loss is-13.4 dB,and the average crosstalk is-30.5 dB.The optical-node architecture is suit for mode division multiplexing(MDM)optical communication system. 展开更多
关键词 optical node multi-granularity switching flexible-grid switching
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Development of homozygous tetraploid potato and whole genome doubling-induced the enrichment of H3K27ac and potentially enhanced resistance to cold-induced sweetening in tubers
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作者 Hongwei Guo Min Zhou +8 位作者 Guoyan Zhang Li He Caihong Yan Min Wan Jianjun Hu Wei He Deying Zeng bo zhu Zixian Zeng 《Horticulture Research》 SCIE CSCD 2023年第3期271-283,共13页
Polyploid plants typically display advantages on some agronomically important traits over their diploid counterparts.Extensive studies have shown genetic,transcriptomic,and epigenetic dynamics upon polyploidization in... Polyploid plants typically display advantages on some agronomically important traits over their diploid counterparts.Extensive studies have shown genetic,transcriptomic,and epigenetic dynamics upon polyploidization in multiple plant species.However,few studies have unveiled those alternations imposed only by ploidy level,without any interference from heterozygosity.Cultivated potato is highly heterozygous.Thus,in this study,we developed two homozygous autotetraploid lines and one homozygous diploid line in parallel from a homozygous diploid potato.We confirmed their ploidy levels using chloroplast counting and karyotyping.Oligo-FISH and genome re-sequencing validated that these potato lines are nearly homozygous.We investigated variations in phenotypes,transcription,and histone modifications between two ploidies.Both autotetraploid lines produced larger but fewer tubers than the diploid line.Interestingly,each autotetraploid line displayed ploidy-related differential expression for various genes.We also discovered a genomewide enrichment of H3K27ac in genic regions upon whole-genome doubling(WGD).However,such enrichment was not associated with the differential gene expression between two ploidies.The tetraploid lines may exhibit better resistance to cold-induced sweetening(CIS)than the diploid line in tubers,potentially regulated through the expression of CIS-related key genes,which seems to be associated with the levels of H3K4me3 in cold-stored tubers.These findings will help to understand the impacts of autotetraploidization on dynamics of phenotypes,transcription,and histone modifications,as well as on CIS-related genes in response to cold storage. 展开更多
关键词 HOMOZYGOUS doubling RESISTANCE
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中国非小细胞肺癌免疫检查点抑制剂治疗专家共识(2019年版) 被引量:101
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作者 周彩存 王洁 +13 位作者 步宏 王宝成 韩宝惠 卢铀 王哲海 朱波 王子平 宋启斌 任胜祥 林冬梅 何雅億 胡晓桦 赵洪云 秦叔逵 《中国肺癌杂志》 CAS CSCD 北大核心 2020年第2期65-76,共12页
非小细胞肺癌(non-small cell lung cancer, NSCLC)是肺癌中最常见的病理类型,大多数NSCLC患者在确诊时已属晚期。对于驱动基因突变阴性的患者而言,目前的治疗仍以化疗为主,总体预后较差,改善治疗现状、获得长期生存是晚期NSCLC患者最... 非小细胞肺癌(non-small cell lung cancer, NSCLC)是肺癌中最常见的病理类型,大多数NSCLC患者在确诊时已属晚期。对于驱动基因突变阴性的患者而言,目前的治疗仍以化疗为主,总体预后较差,改善治疗现状、获得长期生存是晚期NSCLC患者最迫切的需求。近年来,肿瘤免疫治疗发展迅速,免疫检查点抑制剂(immune checkpoint inhibitors, ICIs),尤其是以程序性死亡因子-1(programmed death-1, PD-1)/程序性死亡因子配体-1(programmed deathligand 1, PD-L1)为靶点的ICIs在驱动基因突变阴性的NSCLC治疗中取得了突破性的进展,为患者带来了生存获益,改变了NSCLC的治疗格局,显示出越来越重要的地位。由中国临床肿瘤学会(Chinese society of clinical oncology, CSCO)NSCLC专家委员会牵头,组织该领域的相关专家,在参考国内外文献、系统评价中外临床研究结果、结合专家经验与体会的基础上,达成统一意见并制定本共识,以期指导国内同行更好地应用ICIs治疗NSCLC。 展开更多
关键词 肺肿瘤 肿瘤免疫治疗 免疫检查点抑制剂 PD-1/PD-L1
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中国非小细胞肺癌免疫检查点抑制剂治疗专家共识(2020年版) 被引量:79
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作者 周彩存 王洁 +22 位作者 王宝成 程颖 王哲海 韩宝惠 卢铀 伍钢 张力 宋勇 朱波 胡毅 王子平 宋启斌 任胜祥 何雅億 胡晓桦 张艰 姚煜 赵洪云 王志杰 褚倩 段建春 柳菁菁 秦叔逵 《中国肺癌杂志》 CAS CSCD 北大核心 2021年第4期217-235,共19页
非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌最常见的病理类型。晚期NSCLC的系统性抗肿瘤治疗经历了化疗、靶向治疗及免疫治疗的变革,患者总体生存时间不断延长。免疫检查点抑制剂(immune checkpoint inhibitors,ICIs),尤其... 非小细胞肺癌(non-small cell lung cancer,NSCLC)是肺癌最常见的病理类型。晚期NSCLC的系统性抗肿瘤治疗经历了化疗、靶向治疗及免疫治疗的变革,患者总体生存时间不断延长。免疫检查点抑制剂(immune checkpoint inhibitors,ICIs),尤其是程序性死亡分子-1(programmed cell death protein 1,PD-1)/程序性死亡分子配体-1(programmed death-ligand 1,PD-L1)抗体已成为表皮生长因子受体(epidermal growth factor receptor,EGFR)/间变性淋巴瘤激酶(anaplastic lymphoma kinase,ALK)阴性晚期NSCLC一线及二线的标准治疗和局部晚期NSCLC同步放化疗后标准治疗,并在辅助/新辅助治疗中显示出可喜的结果,改变了NSCLC整体治疗格局。随着越来越多的ICIs在国内获批肺癌适应证,中国临床肿瘤学会(Chinese Society of Clinical Oncology,CSCO)NSCLC专家委员会牵头,组织该领域的专家,结合2019年版专家共识,参考最新国内外文献、临床研究数据及系统评价,在专家共同讨论的基础上,达成统一意见并制定、更新本共识,为国内同行更好地应用ICIs治疗NSCLC提供参考意见。 展开更多
关键词 肺肿瘤 免疫治疗 程序性死亡分子-1/程序性死亡分子配体-1 专家共识
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The Lyman-alpha Solar Telescope (LST) for the ASO-S mission——Ⅰ. Scientific objectives and overview 被引量:8
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作者 Hui Li bo Chen +20 位作者 Li Feng Ying Li Yu Huang Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Jie Zhao Yu-Tong Yang Wei-Qun Gan Cheng Fang Ke-Fei Song Hong Wang Quan-Feng Guo Ling-Ping He bo zhu Cheng zhu Lei Deng Hai-Chao Bao Cai-Xia Cao Zhong-Guang Yang 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2019年第11期23-32,共10页
As one of the payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is aimed at imaging the Sun and the inner corona up to 2.5 R⊙(mean solar radius)in both the... As one of the payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is aimed at imaging the Sun and the inner corona up to 2.5 R⊙(mean solar radius)in both the Lyα(121.6 nm)and visible wavebands with high temporo-spatial resolution,mainly targeting solar flares,coronal mass ejections(CMEs)and filaments/prominences.LST observations allow us to trace solar eruptive phenomena from the disk center to the inner corona,to study the relationships between eruptive prominences/filaments,solar flares and CMEs,to explore the dynamical processes and evolution of solar eruptions,to diagnose solar winds,and to derive physical parameters of the solar atmosphere.LST is actually an instrument suite,which consists of a Solar Disk Imager(SDI),a Solar Corona Imager(SCI),a White-light Solar Telescope(WST)and two Guide Telescopes(GTs).This is the first paper in a series of LST-related papers.In this paper,we introduce the scientific objectives,present an overview of the LST payload and describe the planned observations.The detailed design and data along with potential diagnostics are described in the second(Paper II)and third(Paper III)papers,respectively,appearing in this issue. 展开更多
关键词 SUN flares-Sun coronal mass ejections(CMEs)-Sun filaments prominences-Sun corona-Sun chromosphere-Sun UV radiation
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The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST 被引量:6
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作者 bo Chen Hui Li +47 位作者 Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang bo zhu Chang-bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng zhu Wei-Min Bao Lei Deng Zeng-Shan Yin 《Research in Astronomy and Astrophysics》 SCIE CAS CSCD 2019年第11期33-48,共16页
As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SD... As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. 展开更多
关键词 telescopes—instrumentation high angular resolution—Sun flares—Sun CORONAL mass ejections(CMEs)—Sun UV radiation
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Rapid quantification of hepatitis B virus DNA by real-time PCR using efficient TaqMan probe and extraction of virus DNA 被引量:9
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作者 Yan-Qin Lu Jin-Xiang Han +3 位作者 Peng Qi Wei Xu Yan-Hui Zu bo zhu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第45期7365-7370,共6页
AIM: To rapidly quantify hepatitis B virus (HBV) DNA by real-time PCR using efficient TaqMan probe and extraction methods of virus DNA. METHODS: Three standards were prepared by cloning PCR products which targeted... AIM: To rapidly quantify hepatitis B virus (HBV) DNA by real-time PCR using efficient TaqMan probe and extraction methods of virus DNA. METHODS: Three standards were prepared by cloning PCR products which targeted S, C and X region of HBV genome into pGEM-T vector respectively. A pair of primers and matched TaqMan probe were selected by comparing the copy number and the Ct values of HBV serum samples derived from the three different standard curves using certain serum DNA. Then the efficiency of six HBV DNA extraction methods including guanidinium isothiocyanate, proteinase K, NaI, NaOH lysis, alkaline lysis and simple boiling was analyzed in sample A, B and C by real-time PCR. Meanwhile, 8 clinical HBV serum samples were quantified. RESULTS: The copy number of the same HBV serum sample originated from the standard curve of S, C and X regions was 5.7 × 10^4/mL, 6.3 × 10^2/mL and 1.6 × 10^3/ mL respectively. The relative Ct value was 26.6, 31.8 and 29.5 respectively. Therefore, primers and matched probe from S region were chosen for further optimization of six extraction methods. The copy number of HBV serum samples A, B and C was 3.49 × 10^9/mL, 2.08 × 10^6/mL and 4.40 × 10^7/mL respectively, the relative Ct value was 19.9, 30 and 26.2 in the method of NaOH lysis, which was the efficientest among six methods. Simple boiling showed a slightly lower efficiency than NaOH lysis. Guanidinium isothiocyanate, proteinase K and NaI displayed that the copy number of HBV serum sample A, B and C was around 10^S/mL, meanwhile the Ct value was about 30. Alkaline failed to quantify the copy number of three HBV serum samples. Standard deviation (SD) and coefficient variation (CV) were very low in all 8 clinical HBV serum samples, showing that quantification of HBV DNA in triplicate was reliable and accurate. CONCLUSION: Real-time PCR based on optimized primers and TaqMan probe from S region in combination with NaOH lysis is a simple, rapid and accurate method for quantification of HBV serum DNA. 展开更多
关键词 Hepatitis B virus Serum DNA Real-time PCR Extraction method
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硬质支气管镜联合可弯曲支气管镜治疗12例气道良性肿瘤的临床分析 被引量:10
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作者 高亭 马玉娟 +4 位作者 朱波 原淑莉 何小鹏 刘小伟 王国锋 《中国内镜杂志》 2020年第9期66-71,共6页
目的探讨硬质支气管镜联合可弯曲支气管镜治疗气道良性肿瘤的效果、安全性和可行性。方法回顾性分析2018年12月-2019年10月咸阳市中心医院呼吸与危重症医学科通过硬质支气管镜介入联合可弯曲支气管镜治疗的气道良性肿瘤12例。观察治疗... 目的探讨硬质支气管镜联合可弯曲支气管镜治疗气道良性肿瘤的效果、安全性和可行性。方法回顾性分析2018年12月-2019年10月咸阳市中心医院呼吸与危重症医学科通过硬质支气管镜介入联合可弯曲支气管镜治疗的气道良性肿瘤12例。观察治疗前后患者临床表现、气道内径、气促指数、第1秒用力呼气容积(FEV1)的变化情况,并对不同类型气道良性肿瘤影像学、镜下表现进行分析。结果采用硬质支气管镜介入联合可弯曲支气管镜治疗后,12例患者临床表现均得到明显改善,治疗前后气道内径和FEV1变化情况比较,差异均有统计学意义,且气促指数明显改善,治疗过程中1例患者出血较多,约30 mL,使用球囊压迫止血后好转,无1例患者死亡。结论应用硬质支气管镜介入联合可弯曲支气管镜治疗气道良性肿瘤,可以快速清除瘤体组织,缓解气道狭窄,改善患者临床症状,是一种高效、安全的方法,具有良好的临床应用前景。 展开更多
关键词 硬质支气管镜 可弯曲支气管镜 介入治疗 良性气道肿瘤 治疗效果 并发症
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Genome wide association study identifies SNPs associated with fatty acid composition in Chinese Wagyu cattle 被引量:4
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作者 Zezhao Wang bo zhu +10 位作者 Hong Niu Wengang Zhang Ling Xu Lei Xu Yan Chen Lupei Zhang Xue Gao Huijiang Gao Shengli Zhang Lingyang Xu Junya Li 《Journal of Animal Science and Biotechnology》 SCIE CAS CSCD 2019年第2期353-364,共12页
Background: Fatty acids are important traits that affect meat quality and nutritive values in beef cattle. Detection of genetic variants for fatty acid composition can help to elucidate the genetic mechanism underpinn... Background: Fatty acids are important traits that affect meat quality and nutritive values in beef cattle. Detection of genetic variants for fatty acid composition can help to elucidate the genetic mechanism underpinning these traits and promote the improvement of fatty acid profiles. In this study, we performed a genome-wide association study(GWAS) on fatty acid composition using high-density single nucleotide polymorphism(SNP) arrays in Chinese Wagyu cattle.Results: In total, we detected 15 and 8 significant genome-wide SNPs for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, respectively. Also, we identified nine candidate genes based on 100 kb regions around associated SNPs. Four SNPs significantly associated with C14:1 cis-9 were embedded with stearoyl-CoA desaturase(SCD), while three SNPs in total were identified for C22:6 n-3 within Phospholipid scramblase family member 5(PLSCR5), Cytoplasmic linker associated protein 1(CLASP1), and Chymosin(CYM). Notably, we found the top candidate SNP within SCD can explain ~ 7.37% of phenotypic variance for C14:1 cis-9.Moreover, we detected several blocks with high LD in the 100 kb region around SCD. In addition, we found three significant SNPs within a 100 kb region showing pleiotropic effects related to multiple FA groups(PUFA,n-6, and PUFA/SFA), which contains BAI1 associated protein 2 like 2(BAIAP2 L2), MAF bZIP transcription factor F(MAFF),and transmembrane protein 184 B(TMEM184 B).Conclusions: Our study identified several significant SNPs and candidate genes for individual fatty acids and fatty acid groups in Chinese Wagyu cattle, and these findings will further assist the design of breeding programs for meat quality in cattle. 展开更多
关键词 CHINESE WAGYU CATTLE FATTY acids GWAS MEAT quality PLEIOTROPIC effects
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Responses of Soil Bacterial Diversity to Fertilization are Driven by Local Environmental Context Across China 被引量:4
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作者 Youzhi Feng Manuel Delgado-Baquerizo +11 位作者 Yongguan zhu Xiaozeng Han Xiaori Han Xiuli Xin Wei Li Zhibing Guo Tinghui Dang Chenhua Li bo zhu Zejiang Cai Daming Li Jiabao Zhang 《Engineering》 SCIE EI CAS 2022年第5期164-170,共7页
Soil microbial diversity is extremely vulnerable to fertilization,which is one of the main anthropogenic activities associated with global changes.Yet we know little about how and why soil microbial diversity responds... Soil microbial diversity is extremely vulnerable to fertilization,which is one of the main anthropogenic activities associated with global changes.Yet we know little about how and why soil microbial diversity responds to fertilization across contrasting local ecological contexts.This knowledge is fundamental for predicting changes in soil microbial diversity in response to ongoing global changes.We analyzed soils from ten 20-year field fertilization(organic and/or inorganic)experiments across China and found that the national-scale responses of soil bacterial diversity to fertilization are dependent on ecological context.In acidic soils from regions with high precipitation and soil fertility,inorganic fertilization can result in further acidification,resulting in negative impacts on soil bacterial diversity.In comparison,organic fer-tilization causes a smaller disturbance to soil bacterial diversity.Despite the overall role of environmental contexts in driving soil microbial diversity,a small group of bacterial taxa were found to respond to fer-tilization in a consistent way across contrasting regions throughout China.Taxa such as Nitrosospira and Nitrososphaera,which benefit from nitrogen fertilizer addition,as well as Chitinophagaceae,Bacilli,and phototrophic bacteria,which respond positively to organic fertilization,could be used as bioindicators for soil fertility in response to fertilization at the national scale.Overall,our work provides new insights into the importance of local environmental context in determining the responses of soil microbial diver-sity to fertilization,and identifies regions with acidic soils wherein soil microbial diversity is more vul-nerable to fertilization at the national scale. 展开更多
关键词 Nutrient addition Anthropogenic activity BIODIVERSITY Soil pH
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