Chronic wounds affect over 6.5 million Americans and are notoriously difficult to treat.Suboptimal oxygenation of the wound bed is one of the most critical and treatable wound management factors,but existing oxygenati...Chronic wounds affect over 6.5 million Americans and are notoriously difficult to treat.Suboptimal oxygenation of the wound bed is one of the most critical and treatable wound management factors,but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable platform.Thus,we developed a low-cost alternative for continuous O 2 delivery and sensing comprising of an inexpensive,paper-based,biocompatible,flexible platform for locally generating and measuring oxygen in a wound region.The platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology,inkjet printing.Here,we demonstrate the functionality of the oxygenation patch,capable of increasing oxygen concentration in a gel substrate by 13%(5ppm)in 1h.The platform is able to sense oxygen in a range of 5–26 ppm.In vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.展开更多
In this paper,we present a disposable,colorimetric,user-friendly and mass-customizable dermal patch for chronological collection and discrete real-time in situ measurement of sweat secretion over a small area of skin....In this paper,we present a disposable,colorimetric,user-friendly and mass-customizable dermal patch for chronological collection and discrete real-time in situ measurement of sweat secretion over a small area of skin.The patch consists of a laminated filter paper patterned into radially arranged channels/fingers with water-activated dyes at their tips.As channels are filled during perspiration,their tips change color once fully saturated,providing easily identifiable levels of water loss which in turn can be mapped to personal dehydration levels.The patch can be manufactured at low cost in a variety of sizes to allow hydration monitoring for individuals participating in activities under different conditions(intensity,temperature,humidity,etc.).Furthermore,we describe an analytical model that enables mass customization of such a flexible wearable system accommodating a broad range of sweat rates and volumes to generate patch designs that are personalized to an individual’s sweat rate,desired time of usage,and the temporal resolution of the required feedback.As a proof-of-concept demonstration,we characterized laser-fabricated patches that cover(7 cm×5 cm)area of skin having various wicking materials,thicknesses(180–540μm),and pore sizes(3–11μm).Tests were conducted at various flow rates simulating different sweating intensities in the range of 1.5–15 mg/cm^(2)/min.Experimental results for the case of a half-marathon runner targeting 90 min of usage and sweating at a rate of 1.5 mg/cm2/min indicated measurement accuracy of 98.3%when the patch is completely filled.展开更多
基金The authors thank the staff of the Birck Nanotechnology Center for their support.Funding for this work was provided by NextFlex under AFRL Cooperative Agreement No.FA8650-15-2-5401.
文摘Chronic wounds affect over 6.5 million Americans and are notoriously difficult to treat.Suboptimal oxygenation of the wound bed is one of the most critical and treatable wound management factors,but existing oxygenation systems do not enable concurrent measurement and delivery of oxygen in a convenient wearable platform.Thus,we developed a low-cost alternative for continuous O 2 delivery and sensing comprising of an inexpensive,paper-based,biocompatible,flexible platform for locally generating and measuring oxygen in a wound region.The platform takes advantage of recent developments in the fabrication of flexible microsystems including the incorporation of paper as a substrate and the use of a scalable manufacturing technology,inkjet printing.Here,we demonstrate the functionality of the oxygenation patch,capable of increasing oxygen concentration in a gel substrate by 13%(5ppm)in 1h.The platform is able to sense oxygen in a range of 5–26 ppm.In vivo studies demonstrate the biocompatibility of the patch and its ability to double or triple the oxygen level in the wound bed to clinically relevant levels.
基金This research was supported in part by NextFlex(P.C.1.0)under AFRL Cooperative Agreement No.FA8650-15-2-5401.
文摘In this paper,we present a disposable,colorimetric,user-friendly and mass-customizable dermal patch for chronological collection and discrete real-time in situ measurement of sweat secretion over a small area of skin.The patch consists of a laminated filter paper patterned into radially arranged channels/fingers with water-activated dyes at their tips.As channels are filled during perspiration,their tips change color once fully saturated,providing easily identifiable levels of water loss which in turn can be mapped to personal dehydration levels.The patch can be manufactured at low cost in a variety of sizes to allow hydration monitoring for individuals participating in activities under different conditions(intensity,temperature,humidity,etc.).Furthermore,we describe an analytical model that enables mass customization of such a flexible wearable system accommodating a broad range of sweat rates and volumes to generate patch designs that are personalized to an individual’s sweat rate,desired time of usage,and the temporal resolution of the required feedback.As a proof-of-concept demonstration,we characterized laser-fabricated patches that cover(7 cm×5 cm)area of skin having various wicking materials,thicknesses(180–540μm),and pore sizes(3–11μm).Tests were conducted at various flow rates simulating different sweating intensities in the range of 1.5–15 mg/cm^(2)/min.Experimental results for the case of a half-marathon runner targeting 90 min of usage and sweating at a rate of 1.5 mg/cm2/min indicated measurement accuracy of 98.3%when the patch is completely filled.
