The aim of this study was to detect evidence for signatures of recent selection in the Jinhua pig genome.These results can be useful to better understand the regions under selection in Jinhua pigs and might shed some ...The aim of this study was to detect evidence for signatures of recent selection in the Jinhua pig genome.These results can be useful to better understand the regions under selection in Jinhua pigs and might shed some lights on groups of genes that control production traits.In the present study,we performed extended haplotype homozygosity(EHH)tests to identify significant core regions in 202 Jinhua pigs.A total of 26161 core regions spanning 636.42 Mb were identified,which occupied approximately 28%of the genome across all autosomes,and 1158 significant(P<0.01)core haplotypes were selected.Genes in these regions were related to several economically important traits,including meat quality,reproduction,immune responses and exterior traits.A panel of genes including ssc-mir-365-2,KDM8,RABEP2,GSG1L,RHEB,RPH3AL and a signal pathway of PI3K-Akt were detected with the most extreme P-values.The findings in our study could draw a comparatively genome-wide map of selection signature in the pig genome,and also help to detect functional candidate genes under positive selection for further genetic and breeding research in Jinhua and other pigs.展开更多
Pituitary Specific transcription factor 1 (PIT-1) gene is one of the POU gene family and play key roles in the regulation of muscle development which is important for body weight in chickens. This study was carried ou...Pituitary Specific transcription factor 1 (PIT-1) gene is one of the POU gene family and play key roles in the regulation of muscle development which is important for body weight in chickens. This study was carried out to detect the polymorphism of PIT-1 gene and study its association with body weight in Fulani and Yoruba ecotype of Nigerian indigenous chickens. A total of 100 day-old chicks comprising of fifty chicks of Fulani and Yoruba ecotypes were used for this study. These chicks were genotyped using PCR-RFLP technique and their growth rate was also measured throughout the study. Our results showed two alleles A and B controlling genotypes AA and AB which were significantly associated with bodyweight of the chickens. Interestingly, we found out that AA genotype had the highest frequency of 0.64 and 0.76 compared with AB genotype which had a frequency of 0.36 and 0.24 in the Fulani and Yoruba ecotype respectively. Furthermore, the PIT-1 genotypes (AA and AB) were significantly associated (p < 0.05) with body weight at week 4 and week 12 in Fulani and Yoruba ecotype chicken respectively. PIT-1 gene was polymorphic in Fulani and Yoruba ecotypes of Nigeria Indigenous Chickens.展开更多
基金supported by the Key Technology R&D Program of China(2016C02054-2)the National Natural Science Foundation of China(31872976)。
文摘The aim of this study was to detect evidence for signatures of recent selection in the Jinhua pig genome.These results can be useful to better understand the regions under selection in Jinhua pigs and might shed some lights on groups of genes that control production traits.In the present study,we performed extended haplotype homozygosity(EHH)tests to identify significant core regions in 202 Jinhua pigs.A total of 26161 core regions spanning 636.42 Mb were identified,which occupied approximately 28%of the genome across all autosomes,and 1158 significant(P<0.01)core haplotypes were selected.Genes in these regions were related to several economically important traits,including meat quality,reproduction,immune responses and exterior traits.A panel of genes including ssc-mir-365-2,KDM8,RABEP2,GSG1L,RHEB,RPH3AL and a signal pathway of PI3K-Akt were detected with the most extreme P-values.The findings in our study could draw a comparatively genome-wide map of selection signature in the pig genome,and also help to detect functional candidate genes under positive selection for further genetic and breeding research in Jinhua and other pigs.
文摘Pituitary Specific transcription factor 1 (PIT-1) gene is one of the POU gene family and play key roles in the regulation of muscle development which is important for body weight in chickens. This study was carried out to detect the polymorphism of PIT-1 gene and study its association with body weight in Fulani and Yoruba ecotype of Nigerian indigenous chickens. A total of 100 day-old chicks comprising of fifty chicks of Fulani and Yoruba ecotypes were used for this study. These chicks were genotyped using PCR-RFLP technique and their growth rate was also measured throughout the study. Our results showed two alleles A and B controlling genotypes AA and AB which were significantly associated with bodyweight of the chickens. Interestingly, we found out that AA genotype had the highest frequency of 0.64 and 0.76 compared with AB genotype which had a frequency of 0.36 and 0.24 in the Fulani and Yoruba ecotype respectively. Furthermore, the PIT-1 genotypes (AA and AB) were significantly associated (p < 0.05) with body weight at week 4 and week 12 in Fulani and Yoruba ecotype chicken respectively. PIT-1 gene was polymorphic in Fulani and Yoruba ecotypes of Nigeria Indigenous Chickens.
