Bio-potency of Dictyota ciliata J.Agardh

Objective:To reveal the antibacterial,cytotoxicity,larvicidal potentials of Dictyota ciliata J.Agardh(D.ciliata).Methods:Phytochemical,antibacterial screening,cytotoxicity and larvicidal properties of the D.ciliata extracts were carried out according to standard methods.Cytotoxicity and larvicidal potentials were analyzed by means of computerized probit analysis program.Results:The phytochemical screening showed the presence of steroids,alkaloids,phenolic groups,cardiac glycosides,flavonoids and tannins in the crude extracts of D.ciliata.The methanolic extracts of D.ciliata showed the highest metabolites presence compared to other tested extracts.The antibacterial activity illustrated that the acetone extracts of D.ciliata exhibited the highest zone of inhibition[(10±0.2)mm]against Morganella morganii.Highest larval mortality(50%)was observed in the crude methanolic extracts of D.ciliata against Culex quinquefasciatus(LC_(50)=202.82 mg/L and LC_(90) value is 488.52 mg/L).The result of brine shrimp lethality bioassay showed highest cytotoxicity in methanolic extracts of D.ciliata with LC_(50) and LC_(90) values at 340.14 mg/L and 555.58 mg/L respectively.Conclusions:The results of the present phytochemical analysis and biological assays will help the manufacturers for identification and selection of raw materials for drug production.