Objective(s): To investigate if testosterone levels are higher in patients with preeclampsia compared to normotensive pregnant patients. Study design: The levels of serum total and free testosterone, dehydroepiandrost...Objective(s): To investigate if testosterone levels are higher in patients with preeclampsia compared to normotensive pregnant patients. Study design: The levels of serum total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and sex hormone binding globulin were estimated in 28 patients during the third trimester of pregnancy with established preeclampsia and 25 normotensive women. Results: No statistically significant diffe- rences were noted between the two groups regarding the maternal age, gestational age, body mass index(BMI) haematocrit and neonatal sex. The mean±S.D. total testosterone and free testosterone levels were significantly higher(p< 0.01) in the group with preeclapsia compared to the control group. The values of DHEA-S, androstenedione and sex hormone binding globulin were lower in the group with preeclampsia but the difference did not reach statistical significance. Conclusion(s): The levels of total and free testosterone appear to be higher in patients with preeclampsia compared to normotensive pregnant women during the third trimester of pregnancy. This difference could indicate an involvement of testosterone in the pathophysiology of preeclampsia and stimulates research in the potential role of antiandrogens in the management of preeclampsia.展开更多
Objective: To investigate the efficacy of the tension- free vaginal tape (TVT) procedure for the management of stress urinary incontinence (SUI) in elderly women. Method: A total of 55 women aged between 65 and 86 yea...Objective: To investigate the efficacy of the tension- free vaginal tape (TVT) procedure for the management of stress urinary incontinence (SUI) in elderly women. Method: A total of 55 women aged between 65 and 86 years underwent a TVT procedure for urodynamic SUI. Of these, 15 (27% ) had undergone previous surgery for treatment of SUI. Before the TVT procedure, a complete medical history was taken and a gynecologic examination performed. Results: Operating time ranged between 11 and 35 min (excluding the time of concomitant surgery, if any); hospitalization time ranged between 1 and 5 days; and no severe intraoperative or postoperative complications occurred. Cure occurred in 39 (76% ) of 51 evaluable patients and its rate was positively associated with bladder neck mobility. Among patients in whom the angle of displacement on the Q- tip test was less than 30° , 42% became continent whereas among those in whom it was 30° or higher, 90% became continent (P < .001). Among those in whom the angle was between 20° and 30° , 57% became continent, and among those in whom it was less than 10° , 80% remained incontinent. Conclusion: The TVT procedure in elderly women with SUI offers a satisfactory cure rate; however, in patients with significantly decreased bladder neck mobility (an angle < 20° on the Q- tip test), the results are not encouraging.展开更多
文摘Objective(s): To investigate if testosterone levels are higher in patients with preeclampsia compared to normotensive pregnant patients. Study design: The levels of serum total and free testosterone, dehydroepiandrosterone sulfate, androstenedione and sex hormone binding globulin were estimated in 28 patients during the third trimester of pregnancy with established preeclampsia and 25 normotensive women. Results: No statistically significant diffe- rences were noted between the two groups regarding the maternal age, gestational age, body mass index(BMI) haematocrit and neonatal sex. The mean±S.D. total testosterone and free testosterone levels were significantly higher(p< 0.01) in the group with preeclapsia compared to the control group. The values of DHEA-S, androstenedione and sex hormone binding globulin were lower in the group with preeclampsia but the difference did not reach statistical significance. Conclusion(s): The levels of total and free testosterone appear to be higher in patients with preeclampsia compared to normotensive pregnant women during the third trimester of pregnancy. This difference could indicate an involvement of testosterone in the pathophysiology of preeclampsia and stimulates research in the potential role of antiandrogens in the management of preeclampsia.
文摘Objective: To investigate the efficacy of the tension- free vaginal tape (TVT) procedure for the management of stress urinary incontinence (SUI) in elderly women. Method: A total of 55 women aged between 65 and 86 years underwent a TVT procedure for urodynamic SUI. Of these, 15 (27% ) had undergone previous surgery for treatment of SUI. Before the TVT procedure, a complete medical history was taken and a gynecologic examination performed. Results: Operating time ranged between 11 and 35 min (excluding the time of concomitant surgery, if any); hospitalization time ranged between 1 and 5 days; and no severe intraoperative or postoperative complications occurred. Cure occurred in 39 (76% ) of 51 evaluable patients and its rate was positively associated with bladder neck mobility. Among patients in whom the angle of displacement on the Q- tip test was less than 30° , 42% became continent whereas among those in whom it was 30° or higher, 90% became continent (P < .001). Among those in whom the angle was between 20° and 30° , 57% became continent, and among those in whom it was less than 10° , 80% remained incontinent. Conclusion: The TVT procedure in elderly women with SUI offers a satisfactory cure rate; however, in patients with significantly decreased bladder neck mobility (an angle < 20° on the Q- tip test), the results are not encouraging.
