Achieving the detachment of divertor can help to alleviate excessive heat load and sputtering problems on the target plates,thereby extending the lifetime of divertor components for fusion devices.In order to provide ...Achieving the detachment of divertor can help to alleviate excessive heat load and sputtering problems on the target plates,thereby extending the lifetime of divertor components for fusion devices.In order to provide a fast but relatively reliable prediction of plasma parameters along the flux tube for future device design,a one-dimensional(1D)modeling code for the operating point of impurity seeded detached divertor is developed based on Python language,which is a fluid model based on previous work(Plasma Phys.Control.Fusion 58045013(2016)).The experimental observation of the onset of divertor detachment by neon(Ne)and argon(Ar)seeding in EAST is well reproduced by using the 1D modeling code.The comparison between the 1D modeling and two-dimensional(2D)simulation by the SOLPS-ITER code for CFETR detachment operation with Ne and Ar seeding also shows that they are in good agreement.We also predict the radiative power loss and corresponding impurity concentration requirement for achieving divertor detachment via different impurity seeding under high heating power conditions in EAST and CFETR phase II by using the 1D model.Based on the predictions,the optimized parameter space for divertor detachment operation on EAST and CFETR is also determined.Such a simple but reliable 1D model can provide a reasonable parameter input for a detailed and accurate analysis by 2D or three-dimensional(3D)modeling tools through rapid parameter scanning.展开更多
In the ELMy H-mode experiment,naturally occurring dust originating at the high-field side is clearly observed using the high-speed vacuum ultraviolet imaging system developed on the Experimental Advanced Superconducti...In the ELMy H-mode experiment,naturally occurring dust originating at the high-field side is clearly observed using the high-speed vacuum ultraviolet imaging system developed on the Experimental Advanced Superconducting Tokamak(EAST).The main ablation cloud shape is similar to the classical shape observed in pellet fueling experiments.However,during the dust penetration,an erupted secondary cloudlet with a bent‘cigar’shape is observed and moves upwards along the direction perpendicular to the magnetic field line,which is different to the obviation in the pellet fueling experiments.This may be due to the ion diamagnetic drift effect.The velocities of the secondary cloudlet are estimated to be 50–80 m s^(-1).In addition,a significant degradation of the plasma confinement is observed during the dust penetration.展开更多
A high-speed vacuum ultraviolet(VUV) imaging system has been developed on the Experimental Advanced Superconducting Tokamak(EAST), which selectively measures line emission with a central wavelength of 13.5 nm(CVI, n=4...A high-speed vacuum ultraviolet(VUV) imaging system has been developed on the Experimental Advanced Superconducting Tokamak(EAST), which selectively measures line emission with a central wavelength of 13.5 nm(CVI, n=4–2). It has been employed to study edge/pedestal plasma behavior in EAST. Edge localized mode(ELM)-induced filament structures have been captured by the VUV imaging system during the ELMy high confinement mode discharge with both high temporal and spatial resolutions. The typical features(i.e.poloidal width and pitch angle) of the observed filaments are quantitatively characterized based on the VUV imaging data, and the dependence of these features on basic plasma parameters is analyzed. It is found that the poloidal width is proportional to the heating power, and the pitch angle is inversely proportional to the edge safety factor q.95 The scatterplot shows a positive trend between the poloidal width and the ELM amplitude defined by the relative change in stored energy. These results are based on the condition that the perturbation induced by ELMs is confined to a narrow layer in the plasma.展开更多
An investigation into tungsten(W)impurity behaviors with the update of the EAST lower W divertor for H-mode has been carried out using SOLPS-ITER.This work aims to study the effect of external neon(Ne)impurity seeding...An investigation into tungsten(W)impurity behaviors with the update of the EAST lower W divertor for H-mode has been carried out using SOLPS-ITER.This work aims to study the effect of external neon(Ne)impurity seeding on W impurity sputtering with the bundled charge state model.As the Ne seeding rate increases,plasma parameters,W concentration(C_(W)),and eroded W flux(Γ_(W)^(Ero))at both targets are compared and analyzed between the highly resolved bundled model‘jett’and the full W charge state model.The results indicate that‘jett’can produce divertor behaviors essentially in agreement with the full W charge state model.The bundled scheme with high resolution in low W charge states(<W^(20+))has no obvious effect on the Ne impurity distribution and thus little effect on W sputtering by Ne.Meanwhile,parametric scans of radial particle and thermal transport diffusivities(D_(⊥)andχ_(e,i))in the SOL are simulated using the‘jett’bundled model.The results indicate that the transport diffusivity variations have significant influences on the divertor parameters,especially for W impurity sputtering.展开更多
Patients with ulcerative colitis(UC)often loss responses over long term usage of conventional therapies.Tofacitinib,a pan-Janus kinases(JAK)inhibitor is approved for moderate to severe UC treatment,while dose-limiting...Patients with ulcerative colitis(UC)often loss responses over long term usage of conventional therapies.Tofacitinib,a pan-Janus kinases(JAK)inhibitor is approved for moderate to severe UC treatment,while dose-limiting systemic side effects including infections,cancers and lymphoma limit its popularity of clinical application.This study sought to construct an anti-mucosal vascular addressin cell-adhesion molecule-1(anti-MAdCAM-1)antibody modified reactive oxygen species(ROS)responsive human serum albumin-based nanomedicine denoted as THM,to improve the therapeutic efficacy of tofacitinib for UC treatment.THM has the drug releasing properties in response to ROS stimulation.In vitro studies show that THM selectively adhered to the endothelial cells and had obvious anti-inflammatory effect on macrophages.Meanwhile,the nanomedicine can inhibit the phenotypic switching of M1 macrophages and promote M2 polarization to produce anti-inflammatory medicators during wound healing.In addition,in vivo fluorescence imaging verified that THM exhibited enhanced preferential accumulation and extended retention in inflamed colon.Moreover,THM significantly reduced the production of proinflammatory cytokines in the colon and suppressed the homing of T cells to the gut in dextran sodium sulfate induced experimental colitis.This work elucidates that the inflamed colon-targeted delivery of tofacitinib by nanomedicine is promising for UC treatment and sheds light on addressing the unmet medical need.展开更多
Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disea...Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disease.However,the relationship and causal roles of these two pathological changes in neurodegeneration remain to be defined,even though they occur together or independently in several neurodegenerative diseases associated with cognitive and movement impairment.展开更多
Extreme learning machine(ELM)is a feedforward neural network with a single layer of hidden nodes,where the weight and the bias connecting input to hidden nodes are randomly assigned.The output weight between hidden no...Extreme learning machine(ELM)is a feedforward neural network with a single layer of hidden nodes,where the weight and the bias connecting input to hidden nodes are randomly assigned.The output weight between hidden nodes and outputs are learned by a linear model.It is interesting to ask whether the training error of ELM is significantly affected by the hidden layer output matrix H,because a positive answer will enable us obtain smaller training error from better H.For single hidden layer feedforward neural network(SLFN)with one input neuron,there is significant difference between the training errors of different Hs.We find there is a reliable strong negative rank correlation between the training errors and some singular values of the Moore-Penrose generalized inverse of H.Based on the rank correlation,a selection algorithm is proposed to choose robust appropriate H to achieve smaller training error among numerous Hs.Extensive experiments are carried out to validate the selection algorithm,including tests on real data set.The results show that it achieves better performance in validity,speed and robustness.展开更多
The growth of p-type GaAs nanowires（NWs）on GaAs（111）B substrates by metal-organic chemical vapor deposition（MOCVD）has been systematically investigated as a function of diethyl zinc（DEZn）flow.The growth rate of...The growth of p-type GaAs nanowires（NWs）on GaAs（111）B substrates by metal-organic chemical vapor deposition（MOCVD）has been systematically investigated as a function of diethyl zinc（DEZn）flow.The growth rate of GaAs NWs was slightly improved by Zn-doping and kink is observed under high DEZn flow.In addition,the Ⅰ–Ⅴ curves of GaAs NWs has been measured and the p-type dope concentration under the Ⅱ/Ⅲ ratio of 0.013 and 0.038 approximated to 1019–1020展开更多
基金Project supported by the National Key Research and Development Program of China (Grant No.2022YFE03030001)the National Natural Science Foundation of China (Grant No.12075283)。
文摘Achieving the detachment of divertor can help to alleviate excessive heat load and sputtering problems on the target plates,thereby extending the lifetime of divertor components for fusion devices.In order to provide a fast but relatively reliable prediction of plasma parameters along the flux tube for future device design,a one-dimensional(1D)modeling code for the operating point of impurity seeded detached divertor is developed based on Python language,which is a fluid model based on previous work(Plasma Phys.Control.Fusion 58045013(2016)).The experimental observation of the onset of divertor detachment by neon(Ne)and argon(Ar)seeding in EAST is well reproduced by using the 1D modeling code.The comparison between the 1D modeling and two-dimensional(2D)simulation by the SOLPS-ITER code for CFETR detachment operation with Ne and Ar seeding also shows that they are in good agreement.We also predict the radiative power loss and corresponding impurity concentration requirement for achieving divertor detachment via different impurity seeding under high heating power conditions in EAST and CFETR phase II by using the 1D model.Based on the predictions,the optimized parameter space for divertor detachment operation on EAST and CFETR is also determined.Such a simple but reliable 1D model can provide a reasonable parameter input for a detailed and accurate analysis by 2D or three-dimensional(3D)modeling tools through rapid parameter scanning.
基金supported in part by the National Key R&D Program of China(Nos.2019YFE03080200,2022YFE03030001 and2022YFE03050003)National Natural Science Foundation of China(Nos.11975271,12075284,12075283 and 12175277)+1 种基金the Chinese Academy of President’s International Fellowship Initiative(No.2021VMA0022)the Post-CUP program,JSPS-CAS Bilateral Joint Research Projects,‘Control of wall recycling on metallic plasma facing materials in fusion reactor’,2019–2022,(No.GJHZ201984)。
文摘In the ELMy H-mode experiment,naturally occurring dust originating at the high-field side is clearly observed using the high-speed vacuum ultraviolet imaging system developed on the Experimental Advanced Superconducting Tokamak(EAST).The main ablation cloud shape is similar to the classical shape observed in pellet fueling experiments.However,during the dust penetration,an erupted secondary cloudlet with a bent‘cigar’shape is observed and moves upwards along the direction perpendicular to the magnetic field line,which is different to the obviation in the pellet fueling experiments.This may be due to the ion diamagnetic drift effect.The velocities of the secondary cloudlet are estimated to be 50–80 m s^(-1).In addition,a significant degradation of the plasma confinement is observed during the dust penetration.
基金supported in part by the National Key R&D Program of China (No. 2017YFE0301205)National Natural Science Foundation of China (Nos. 11975271, 12075284 and 12075283)partly supported by Chinese Academy of President’s International Fellowship Initiative (Grant No. 2021 VMA0022)。
文摘A high-speed vacuum ultraviolet(VUV) imaging system has been developed on the Experimental Advanced Superconducting Tokamak(EAST), which selectively measures line emission with a central wavelength of 13.5 nm(CVI, n=4–2). It has been employed to study edge/pedestal plasma behavior in EAST. Edge localized mode(ELM)-induced filament structures have been captured by the VUV imaging system during the ELMy high confinement mode discharge with both high temporal and spatial resolutions. The typical features(i.e.poloidal width and pitch angle) of the observed filaments are quantitatively characterized based on the VUV imaging data, and the dependence of these features on basic plasma parameters is analyzed. It is found that the poloidal width is proportional to the heating power, and the pitch angle is inversely proportional to the edge safety factor q.95 The scatterplot shows a positive trend between the poloidal width and the ELM amplitude defined by the relative change in stored energy. These results are based on the condition that the perturbation induced by ELMs is confined to a narrow layer in the plasma.
基金supported by National Natural Science Foundation of China(Nos.12075283 and 11975271)。
文摘An investigation into tungsten(W)impurity behaviors with the update of the EAST lower W divertor for H-mode has been carried out using SOLPS-ITER.This work aims to study the effect of external neon(Ne)impurity seeding on W impurity sputtering with the bundled charge state model.As the Ne seeding rate increases,plasma parameters,W concentration(C_(W)),and eroded W flux(Γ_(W)^(Ero))at both targets are compared and analyzed between the highly resolved bundled model‘jett’and the full W charge state model.The results indicate that‘jett’can produce divertor behaviors essentially in agreement with the full W charge state model.The bundled scheme with high resolution in low W charge states(<W^(20+))has no obvious effect on the Ne impurity distribution and thus little effect on W sputtering by Ne.Meanwhile,parametric scans of radial particle and thermal transport diffusivities(D_(⊥)andχ_(e,i))in the SOL are simulated using the‘jett’bundled model.The results indicate that the transport diffusivity variations have significant influences on the divertor parameters,especially for W impurity sputtering.
基金This work was partially supported by grants from the National Natural Science Foundation of China(Nos.31971302 and 82170532)the Natural Science Foundation of Guangdong Province of China(No.2019A1515011597)+2 种基金the talent young scientist supporting program of China Association for Science and Technology,the Educational Commission of Guangdong Province of China key Project(No.2020ZDZX2001)the joint grant between Guangzhou City and College(No.202102010106)Guangzhou Science and Technology Plan Project(No.202201011509).
文摘Patients with ulcerative colitis(UC)often loss responses over long term usage of conventional therapies.Tofacitinib,a pan-Janus kinases(JAK)inhibitor is approved for moderate to severe UC treatment,while dose-limiting systemic side effects including infections,cancers and lymphoma limit its popularity of clinical application.This study sought to construct an anti-mucosal vascular addressin cell-adhesion molecule-1(anti-MAdCAM-1)antibody modified reactive oxygen species(ROS)responsive human serum albumin-based nanomedicine denoted as THM,to improve the therapeutic efficacy of tofacitinib for UC treatment.THM has the drug releasing properties in response to ROS stimulation.In vitro studies show that THM selectively adhered to the endothelial cells and had obvious anti-inflammatory effect on macrophages.Meanwhile,the nanomedicine can inhibit the phenotypic switching of M1 macrophages and promote M2 polarization to produce anti-inflammatory medicators during wound healing.In addition,in vivo fluorescence imaging verified that THM exhibited enhanced preferential accumulation and extended retention in inflamed colon.Moreover,THM significantly reduced the production of proinflammatory cytokines in the colon and suppressed the homing of T cells to the gut in dextran sodium sulfate induced experimental colitis.This work elucidates that the inflamed colon-targeted delivery of tofacitinib by nanomedicine is promising for UC treatment and sheds light on addressing the unmet medical need.
基金This work was supported by the Guangzhou Key Research Program on Brain Science(202007030008,202007030003)The National Natural Science Foundation of China(32170981,81830032,31872779,81922026,82071421,82171244)+2 种基金National Key Research and Development Program of China(2021YFA0805300,2021YFA0805200)Department of Science and Technology of Guangdong Province(2021ZT09Y007,2020B121201006)Key Field Research and Development Program of Guangdong province(2018B030337001).
文摘Tauopathy,characterized by the hyperphosphorylation and accumulation of the microtubule-associated protein tau,and the accumulation of Aβ oligomers,constitute the major pathological hallmarks of Alzheimer's disease.However,the relationship and causal roles of these two pathological changes in neurodegeneration remain to be defined,even though they occur together or independently in several neurodegenerative diseases associated with cognitive and movement impairment.
基金supported by the National Key Research and Development Program of China under Grant No.2020YFA0714200.
文摘Extreme learning machine(ELM)is a feedforward neural network with a single layer of hidden nodes,where the weight and the bias connecting input to hidden nodes are randomly assigned.The output weight between hidden nodes and outputs are learned by a linear model.It is interesting to ask whether the training error of ELM is significantly affected by the hidden layer output matrix H,because a positive answer will enable us obtain smaller training error from better H.For single hidden layer feedforward neural network(SLFN)with one input neuron,there is significant difference between the training errors of different Hs.We find there is a reliable strong negative rank correlation between the training errors and some singular values of the Moore-Penrose generalized inverse of H.Based on the rank correlation,a selection algorithm is proposed to choose robust appropriate H to achieve smaller training error among numerous Hs.Extensive experiments are carried out to validate the selection algorithm,including tests on real data set.The results show that it achieves better performance in validity,speed and robustness.
基金Project supported by the National Natural Science Foundation of China(Nos.61376019,61504010,61774021)the Fund of State Key Laboratory of Information Photonics and Optical Communications(Beijing University of Posts and Telecommunications),China(Nos.IPOC2017ZT02,IPOC2017ZZ01)
文摘The growth of p-type GaAs nanowires（NWs）on GaAs（111）B substrates by metal-organic chemical vapor deposition（MOCVD）has been systematically investigated as a function of diethyl zinc（DEZn）flow.The growth rate of GaAs NWs was slightly improved by Zn-doping and kink is observed under high DEZn flow.In addition,the Ⅰ–Ⅴ curves of GaAs NWs has been measured and the p-type dope concentration under the Ⅱ/Ⅲ ratio of 0.013 and 0.038 approximated to 1019–1020
