近30年来的系外行星探测揭示了行星在宇宙中普遍存在的事实.为了深入研究适宜生命居住行星的普遍性,一方面需要了解宜居行星的特性;另一方面可以通过分析已发现系外行星的分布特征,推算该类行星在恒星周围的存在几率.在目前已发现的系...近30年来的系外行星探测揭示了行星在宇宙中普遍存在的事实.为了深入研究适宜生命居住行星的普遍性,一方面需要了解宜居行星的特性;另一方面可以通过分析已发现系外行星的分布特征,推算该类行星在恒星周围的存在几率.在目前已发现的系外行星中,凌星法发现的占据了绝大多数,如Kepler空间望远镜所观测的系外行星共有2344颗.2018年Kepler正式退役,其科学团队发布了最终版的Kepler Data Release(DR25),包含观测季度Q1–Q17的恒星共198709颗.通过对Kepler数据的分析,使用逆检测效率法和最大似然分析法两种不同的方法对系外行星半径周期参数空间内的行星生成率进行了估算,同时将计算样本根据恒星的光谱类型进行分类,分别估算得到了F、G、K型的Kepler恒星周围的行星生成率及其整体的生成率.对于半径范围1–20 R⊕(R⊕为一个地球半径),轨道周期范围0.4–400 d的Kepler凌星系外行星,宿主恒星为F型时逆检测效率法和最大似然法估算得到的行星生成率分别为0.36±0.02和0.47±0.02,宿主恒星为G型时的行星生成率分别为1.62±0.05和1.23±0.04,宿主恒星为K型恒星时的行星生成率分别为2.61±0.12和2.73±0.13.而逆检测效率法和最大似然法估算F、G、K型恒星周围存在这类行星的整体生成率分别为1.16±0.03和0.90±0.02.最后,对比分析了不同方法以及不同光谱型恒星间的行星生成率差异,并结合前人研究讨论了该估算结果的可靠性.展开更多
针对现有的脆弱性评估算法无法直接应用于软件定义网络(Software Defined Network,SDN),以及评估技术普遍偏向于网络连通,无法针对服务与传输性能对SDN进行脆弱性分析等问题,提出一种面向服务传输的SDN移动网络脆弱性评估模型与算法,设...针对现有的脆弱性评估算法无法直接应用于软件定义网络(Software Defined Network,SDN),以及评估技术普遍偏向于网络连通,无法针对服务与传输性能对SDN进行脆弱性分析等问题,提出一种面向服务传输的SDN移动网络脆弱性评估模型与算法,设计基于SDN的移动网络脆弱性评估框架。提出一种对基于SDN的移动网络服务器节点与网络设备进行安全脆弱性分析的方法,将静态配置信息和动态运行信息融合评估节点设备的脆弱性,使评估更加全面准确;针对SDN移动网络的服务与传输特性,从传输拓扑和SDN节点活跃度2个方面,计算面向服务与传输的基于SDN的移动网络节点重要度;最后融合节点设备的安全脆弱性和重要度来对基于SDN的移动网络进行脆弱性评估,得到评估结果。通过实例和仿真实验验证了所提算法的有效性,相比同类算法可达到更高的评估准确性。展开更多
Objective： To compare the effects of electroacupuncture （EA） and mild-warm moxibustion （Mox） therapies for constipation-predominant irritable bowel syndrome （C-IBS） patients. Methods： Sixty C-IBS patients were...Objective： To compare the effects of electroacupuncture （EA） and mild-warm moxibustion （Mox） therapies for constipation-predominant irritable bowel syndrome （C-IBS） patients. Methods： Sixty C-IBS patients were assigned to 2 groups by simple randomized method, i.e. EA group （30 cases） and Mox group （30 cases）. Both EA and Mox treatments were performed on bilateral Tianshu （ST 25） and Shangjuxu （ST 37） for 30 min each time, 6 times per week, for 4 consecutive weeks. The gastrointestinal symptoms and psychological symptoms of the two groups were scored before and after treatment. The effects on the corresponding functional brain areas, namely the anterior cingulate cortex （ACC）, insular cortex （IC） and prefrontal cortex （PFC） were observed by functional magnetic resonance imaging （fMRI） before and after treatment. Results： Compared with the Mox group, greater improvements in abdominal distension, defecation frequency, difficulty in defecation and stool features were observed in the EA group （all P〈0.01）, both Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were significantly decreased in the EA group （all P〈0.01）. Finally, decreased activated voxel values were observed in the ACC, right IC and PFC brain regions of EA group with 150 mL colorectal distension stimulation （P〈0.05 or P〈0.01）. Conclusions： Both EA and Mox could significantly improve some of the most intrusive symptoms of C-IBS patients, and EA was more effective than Mox. The therapeutic effect of these two therapies might through modulating of the brain-gut axis function. （Registration No. ChiCTR- TRC-11001349）.展开更多
Objective： To categorize and summarize the clinical and mechanism studies of the past 30 years on the treatment of Hashimoto＇s thyroiditis（HT） with moxibustion, moxibustion plus medication, and acupuncture plus me...Objective： To categorize and summarize the clinical and mechanism studies of the past 30 years on the treatment of Hashimoto＇s thyroiditis（HT） with moxibustion, moxibustion plus medication, and acupuncture plus medication, etc., and to analyze the current problems. Methods： The clinical and laboratory studies related to the treatment of HT with acupuncture-moxibustion therapies published before June 2015 were retrieved from MEDLINE, Excerpta Medica Database（EMBASE）, China National Knowledge Infrastructure（CNKI）, Wanfang Academic Journal Full-text Database（Wanfang） and Chongqing VIP Database（CQVIP）. Results： Moxibustion, moxibustion plus medication, and acupuncture plus medication can produce certain therapeutic effects in treating HT. Conclusion： The research on the treatment of HT with acupuncture-moxibustion therapies is rather limited in the amount and content. In the future, standardization should be fortified, specific moxibustion research needs deepening, and the action mechanism of moxibustion should be emphasized.展开更多
Objective:To explore whether acupuncture combined with moxibustion could inhibit epithelialmesenchymal transition in Crohn’s disease by affecting the transforming growth factorβ1(TGF-β1)/Smad3/Snail pathway.Methods...Objective:To explore whether acupuncture combined with moxibustion could inhibit epithelialmesenchymal transition in Crohn’s disease by affecting the transforming growth factorβ1(TGF-β1)/Smad3/Snail pathway.Methods:Sixty-three patients with Crohn’s disease were randomly divided into an observation group(31 cases)receiving moxibustion at 43℃ combined with acupuncture,and a control group(32 cases)receiving moxibustion at 37℃combined with sham acupuncture using a random number table.Patients were treated for12 weeks.Crohn’s Disease Activity Index(CDAI)was used to evaluate disease activity.Hematoxylin-eosin staining and transmission electron microscopy were utilized to observe the morphological and ultrastructural changes.Immunohistochemistry was used to detect the expression of transforming growth factorβ1(TGF-β1),TβR1,TβR2,Smad3,Snail,E-cadherin and fibronectin in intestinal mucosal tissues.Results:The decrease of the CDAI score,morphological and ultrastructural changes were more significant in observation group.The expression levels of TGF-β1,TβR2,Smad3,and Snail in the observation group were significantly lower than those before the treatment(P<0.05 or P<0.01).After treatment,the expression levels of TGF-β1,TβR2,and Snail in the observation group were significantly lower than those in the control group(all P<0.05);compared with the control group,the expression of fibronectin in the observation group was significantly decreased,and the expression of E-cadherin was significantly increased(all P<0.05).Conclusions:Moxibustion at 43℃combined with acupuncture may suppress TGF-β1/Smad3/Snail pathway-mediated epithelial-mesenchymal transition of intestinal epithelial cells in Crohn’s disease patients by inhibiting the expression levels of TGF-β1,TβR2,Smad3,and Snail.(Registration No.ChiCTR-IIR-16007751).展开更多
文摘近30年来的系外行星探测揭示了行星在宇宙中普遍存在的事实.为了深入研究适宜生命居住行星的普遍性,一方面需要了解宜居行星的特性;另一方面可以通过分析已发现系外行星的分布特征,推算该类行星在恒星周围的存在几率.在目前已发现的系外行星中,凌星法发现的占据了绝大多数,如Kepler空间望远镜所观测的系外行星共有2344颗.2018年Kepler正式退役,其科学团队发布了最终版的Kepler Data Release(DR25),包含观测季度Q1–Q17的恒星共198709颗.通过对Kepler数据的分析,使用逆检测效率法和最大似然分析法两种不同的方法对系外行星半径周期参数空间内的行星生成率进行了估算,同时将计算样本根据恒星的光谱类型进行分类,分别估算得到了F、G、K型的Kepler恒星周围的行星生成率及其整体的生成率.对于半径范围1–20 R⊕(R⊕为一个地球半径),轨道周期范围0.4–400 d的Kepler凌星系外行星,宿主恒星为F型时逆检测效率法和最大似然法估算得到的行星生成率分别为0.36±0.02和0.47±0.02,宿主恒星为G型时的行星生成率分别为1.62±0.05和1.23±0.04,宿主恒星为K型恒星时的行星生成率分别为2.61±0.12和2.73±0.13.而逆检测效率法和最大似然法估算F、G、K型恒星周围存在这类行星的整体生成率分别为1.16±0.03和0.90±0.02.最后,对比分析了不同方法以及不同光谱型恒星间的行星生成率差异,并结合前人研究讨论了该估算结果的可靠性.
文摘针对现有的脆弱性评估算法无法直接应用于软件定义网络(Software Defined Network,SDN),以及评估技术普遍偏向于网络连通,无法针对服务与传输性能对SDN进行脆弱性分析等问题,提出一种面向服务传输的SDN移动网络脆弱性评估模型与算法,设计基于SDN的移动网络脆弱性评估框架。提出一种对基于SDN的移动网络服务器节点与网络设备进行安全脆弱性分析的方法,将静态配置信息和动态运行信息融合评估节点设备的脆弱性,使评估更加全面准确;针对SDN移动网络的服务与传输特性,从传输拓扑和SDN节点活跃度2个方面,计算面向服务与传输的基于SDN的移动网络节点重要度;最后融合节点设备的安全脆弱性和重要度来对基于SDN的移动网络进行脆弱性评估,得到评估结果。通过实例和仿真实验验证了所提算法的有效性,相比同类算法可达到更高的评估准确性。
基金Supported by the National Natural Science Foundation of China(No.30973784)the National Basic Research Program of China,973 program(No.2009CB522900)
文摘Objective： To compare the effects of electroacupuncture （EA） and mild-warm moxibustion （Mox） therapies for constipation-predominant irritable bowel syndrome （C-IBS） patients. Methods： Sixty C-IBS patients were assigned to 2 groups by simple randomized method, i.e. EA group （30 cases） and Mox group （30 cases）. Both EA and Mox treatments were performed on bilateral Tianshu （ST 25） and Shangjuxu （ST 37） for 30 min each time, 6 times per week, for 4 consecutive weeks. The gastrointestinal symptoms and psychological symptoms of the two groups were scored before and after treatment. The effects on the corresponding functional brain areas, namely the anterior cingulate cortex （ACC）, insular cortex （IC） and prefrontal cortex （PFC） were observed by functional magnetic resonance imaging （fMRI） before and after treatment. Results： Compared with the Mox group, greater improvements in abdominal distension, defecation frequency, difficulty in defecation and stool features were observed in the EA group （all P〈0.01）, both Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were significantly decreased in the EA group （all P〈0.01）. Finally, decreased activated voxel values were observed in the ACC, right IC and PFC brain regions of EA group with 150 mL colorectal distension stimulation （P〈0.05 or P〈0.01）. Conclusions： Both EA and Mox could significantly improve some of the most intrusive symptoms of C-IBS patients, and EA was more effective than Mox. The therapeutic effect of these two therapies might through modulating of the brain-gut axis function. （Registration No. ChiCTR- TRC-11001349）.
基金supported by National Basic Research Program of China(973 Program,No.2009CB522900)Scientific Research Project for Traditional Chinese Medicine of Shanghai Municipal Commission of Health and Family Planning(No.2016LQ013)~~
文摘Objective： To categorize and summarize the clinical and mechanism studies of the past 30 years on the treatment of Hashimoto＇s thyroiditis（HT） with moxibustion, moxibustion plus medication, and acupuncture plus medication, etc., and to analyze the current problems. Methods： The clinical and laboratory studies related to the treatment of HT with acupuncture-moxibustion therapies published before June 2015 were retrieved from MEDLINE, Excerpta Medica Database（EMBASE）, China National Knowledge Infrastructure（CNKI）, Wanfang Academic Journal Full-text Database（Wanfang） and Chongqing VIP Database（CQVIP）. Results： Moxibustion, moxibustion plus medication, and acupuncture plus medication can produce certain therapeutic effects in treating HT. Conclusion： The research on the treatment of HT with acupuncture-moxibustion therapies is rather limited in the amount and content. In the future, standardization should be fortified, specific moxibustion research needs deepening, and the action mechanism of moxibustion should be emphasized.
基金Supported by the National Natural Science Foundation of China(Nos.81674069 and 81473757)。
文摘Objective:To explore whether acupuncture combined with moxibustion could inhibit epithelialmesenchymal transition in Crohn’s disease by affecting the transforming growth factorβ1(TGF-β1)/Smad3/Snail pathway.Methods:Sixty-three patients with Crohn’s disease were randomly divided into an observation group(31 cases)receiving moxibustion at 43℃ combined with acupuncture,and a control group(32 cases)receiving moxibustion at 37℃combined with sham acupuncture using a random number table.Patients were treated for12 weeks.Crohn’s Disease Activity Index(CDAI)was used to evaluate disease activity.Hematoxylin-eosin staining and transmission electron microscopy were utilized to observe the morphological and ultrastructural changes.Immunohistochemistry was used to detect the expression of transforming growth factorβ1(TGF-β1),TβR1,TβR2,Smad3,Snail,E-cadherin and fibronectin in intestinal mucosal tissues.Results:The decrease of the CDAI score,morphological and ultrastructural changes were more significant in observation group.The expression levels of TGF-β1,TβR2,Smad3,and Snail in the observation group were significantly lower than those before the treatment(P<0.05 or P<0.01).After treatment,the expression levels of TGF-β1,TβR2,and Snail in the observation group were significantly lower than those in the control group(all P<0.05);compared with the control group,the expression of fibronectin in the observation group was significantly decreased,and the expression of E-cadherin was significantly increased(all P<0.05).Conclusions:Moxibustion at 43℃combined with acupuncture may suppress TGF-β1/Smad3/Snail pathway-mediated epithelial-mesenchymal transition of intestinal epithelial cells in Crohn’s disease patients by inhibiting the expression levels of TGF-β1,TβR2,Smad3,and Snail.(Registration No.ChiCTR-IIR-16007751).
