Magnetic interaction between magnetic particles is of great significance in the fields of magnetic separation and functional materials.A good understanding of interaction mechanism of magnetic particles would further ...Magnetic interaction between magnetic particles is of great significance in the fields of magnetic separation and functional materials.A good understanding of interaction mechanism of magnetic particles would further boost its promising industrial applications.We hereby present our work which visualizes the movement behavior of magnetic spheres in magnetic fields employing high-speed imaging and simulates the dynamic behavior of spheres using an Arbitrary Lagrangian-Eulerian(ALE)based on finite element method.In this paper,we investigated the stress tensor,magnetic force,and dynamic behavior of magnetic spheres in magnetic fields,especially magnetic energy density in different domains.Results show that there are four relatively independent regions of magnetic energy density distribution in external spatial domains of a single sphere system.Attractive force will generate when the energy density in the spatial region between two spheres is relatively high,while a repulsive force will generate when the energy density in the spatial region between two spheres is relatively low.Every magnetic sphere spontaneously moves towards the region with high energy density and stays away from the region with low energy density.The total magnetic energy in magnetic spheres’domains(V_(1))and external spatial domains(V_(2))increases,but the magnetic energy in the external spatial domain decreases over time during the aggregation process.The magnetic spheres ultimately arrange in chain-like structures oriented along magnetic field direction.We hereby proposed a novel and efficient approach to predict the movement trends and final state of magnetic particle swarm from the view of energy density.展开更多
目的以自发突变导致的小头、震颤(microcephaly and seizure,mise)斑马鱼为模型,研究其遗传方式和突变基因定位。方法通过比较正常和突变体斑马鱼的头宽和眼球面积,鉴定突变体的小头小眼性状;通过构建家系确定突变遗传方式。对极端表型...目的以自发突变导致的小头、震颤(microcephaly and seizure,mise)斑马鱼为模型,研究其遗传方式和突变基因定位。方法通过比较正常和突变体斑马鱼的头宽和眼球面积,鉴定突变体的小头小眼性状;通过构建家系确定突变遗传方式。对极端表型群体进行基因组重测序,随后利用分离群体分组分析(bulked segregation analysis,BSA)和竞争性等位基因特异性PCR(kompetitive allele specific PCR,KASP),一代测序等方法获得突变基因定位。结果与野生型相比,突变体mise受精后3 d(3 days post fertilization,3 dpf)表现为小头小眼震颤表型。经基因定位及验证明确与表型相关的突变基因为terfa。结论本研究通过全基因组重测序结合连锁分析的方法快速定位突变基因,可为斑马鱼突变体的基因定位提供参考,为神经系统发育异常的相关基因功能分析奠定基础。展开更多
基金supported by National Natural Science Foundation of China (Nos. 5217040329 and 51674091)Natural Science Foundation of Fujian Province (No. 2021J01640)the Open Foundation of the State Key Laboratory of Mineral Processing (Nos. BGRIMM-KJSKL-2021-02 and BGRIMM-KJSKL2022-03)。
文摘Magnetic interaction between magnetic particles is of great significance in the fields of magnetic separation and functional materials.A good understanding of interaction mechanism of magnetic particles would further boost its promising industrial applications.We hereby present our work which visualizes the movement behavior of magnetic spheres in magnetic fields employing high-speed imaging and simulates the dynamic behavior of spheres using an Arbitrary Lagrangian-Eulerian(ALE)based on finite element method.In this paper,we investigated the stress tensor,magnetic force,and dynamic behavior of magnetic spheres in magnetic fields,especially magnetic energy density in different domains.Results show that there are four relatively independent regions of magnetic energy density distribution in external spatial domains of a single sphere system.Attractive force will generate when the energy density in the spatial region between two spheres is relatively high,while a repulsive force will generate when the energy density in the spatial region between two spheres is relatively low.Every magnetic sphere spontaneously moves towards the region with high energy density and stays away from the region with low energy density.The total magnetic energy in magnetic spheres’domains(V_(1))and external spatial domains(V_(2))increases,but the magnetic energy in the external spatial domain decreases over time during the aggregation process.The magnetic spheres ultimately arrange in chain-like structures oriented along magnetic field direction.We hereby proposed a novel and efficient approach to predict the movement trends and final state of magnetic particle swarm from the view of energy density.
文摘目的以自发突变导致的小头、震颤(microcephaly and seizure,mise)斑马鱼为模型,研究其遗传方式和突变基因定位。方法通过比较正常和突变体斑马鱼的头宽和眼球面积,鉴定突变体的小头小眼性状;通过构建家系确定突变遗传方式。对极端表型群体进行基因组重测序,随后利用分离群体分组分析(bulked segregation analysis,BSA)和竞争性等位基因特异性PCR(kompetitive allele specific PCR,KASP),一代测序等方法获得突变基因定位。结果与野生型相比,突变体mise受精后3 d(3 days post fertilization,3 dpf)表现为小头小眼震颤表型。经基因定位及验证明确与表型相关的突变基因为terfa。结论本研究通过全基因组重测序结合连锁分析的方法快速定位突变基因,可为斑马鱼突变体的基因定位提供参考,为神经系统发育异常的相关基因功能分析奠定基础。
