目的了解在当前全科住院医师(含全科专硕)规范化培训大背景下,带教师资对置信职业行为(entrustable professional activities,EPAs)的应用现状以及客观需求,探索建立全科住院医师EPAs评价考核体系的可行方案。方法采用问卷调查法,对158...目的了解在当前全科住院医师(含全科专硕)规范化培训大背景下,带教师资对置信职业行为(entrustable professional activities,EPAs)的应用现状以及客观需求,探索建立全科住院医师EPAs评价考核体系的可行方案。方法采用问卷调查法,对158位临床带教师资进行调查,分析当前全科住院医师的规范化培训评价体系现状,以及他们对EPAs的了解程度和意见建议。结果在职业行为维度上,师资对医学知识和医学技能的考核效果认可度高;师资认为医德教育中的人文情怀考核不足;在实际需求上,带教师资对EPAs的重视顺序为:规范化(93.04%)、客观化(93.04%)、多维化(92.41%)、轻量化(90.51%)和多样化(86.04%)。结论应针对现行全科住院医师规范化培训体系中人文教育方面存在的短板,并基于中国全科住院医师培训的实际需求设计置信职业行为EPAs体系,在提高师资的教学胜任力的同时保障全科医学教育的产出成果。展开更多
As one of the most lethal diseases,pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities.Furthermore,pancreatic cancer escapes early detection during the curable period be...As one of the most lethal diseases,pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities.Furthermore,pancreatic cancer escapes early detection during the curable period because early symptoms rarely emerge and specific markers for this disease have not been found.Although combinations of new drugs,multimodal therapies,and adjuvants prolong survival,most patients still relapse after surgery and eventually die.Consequently,the search for more effective treatments for pancreatic cancer is highly relevant and justified.As a newly re-discovered mediator of gasotransmission,hydrogen sulfide(H2S)undertakes essential functions,encompassing various signaling complexes that occupy key processes in human biology.Accumulating evidence indicates that H2S exhibits bimodal modulation of cancer development.Thus,endogenous or low levels of exogenous H2S are thought to promote cancer,whereas high doses of exogenous H2S suppress tumor proliferation.Similarly,inhibition of endogenous H2S production also suppresses tumor proliferation.Accordingly,H2S biosynthesis inhibitors and H2S supplementation(H2S donors)are two distinct strategies for the treatment of cancer.Unfortunately,modulation of endogenous H2S on pancreatic cancer has not been studied so far.However,H2S donors and their derivatives have been extensively studied as potential therapeutic agents for pancreatic cancer therapy by inhibiting cell proliferation,inducing apoptosis,arresting cell cycle,and suppressing invasion and migration through exploiting multiple signaling pathways.As far as we know,there is no review of the effects of H2S donors on pancreatic cancer.Based on these concerns,the therapeutic effects of some H2S donors and NO-H2S dual donors on pancreatic cancer were summarized in this paper.Exogenous H2S donors may be promising compounds for pancreatic cancer treatment.展开更多
文摘目的了解在当前全科住院医师(含全科专硕)规范化培训大背景下,带教师资对置信职业行为(entrustable professional activities,EPAs)的应用现状以及客观需求,探索建立全科住院医师EPAs评价考核体系的可行方案。方法采用问卷调查法,对158位临床带教师资进行调查,分析当前全科住院医师的规范化培训评价体系现状,以及他们对EPAs的了解程度和意见建议。结果在职业行为维度上,师资对医学知识和医学技能的考核效果认可度高;师资认为医德教育中的人文情怀考核不足;在实际需求上,带教师资对EPAs的重视顺序为:规范化(93.04%)、客观化(93.04%)、多维化(92.41%)、轻量化(90.51%)和多样化(86.04%)。结论应针对现行全科住院医师规范化培训体系中人文教育方面存在的短板,并基于中国全科住院医师培训的实际需求设计置信职业行为EPAs体系,在提高师资的教学胜任力的同时保障全科医学教育的产出成果。
基金financially supported by Fok Ying Tung Education Foundation(171035,China)State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(CMEMR2018-B04,Guangxi Normal University,China)+1 种基金Highlevel Innovative Project in Shenyang(Young and Middle-aged Technological Innovative Support Plan,RC190483,China)Career Development Support Plan in Shenyang Pharmaceutical University,China。
文摘As one of the most lethal diseases,pancreatic cancer shows a dismal overall prognosis and high resistance to most treatment modalities.Furthermore,pancreatic cancer escapes early detection during the curable period because early symptoms rarely emerge and specific markers for this disease have not been found.Although combinations of new drugs,multimodal therapies,and adjuvants prolong survival,most patients still relapse after surgery and eventually die.Consequently,the search for more effective treatments for pancreatic cancer is highly relevant and justified.As a newly re-discovered mediator of gasotransmission,hydrogen sulfide(H2S)undertakes essential functions,encompassing various signaling complexes that occupy key processes in human biology.Accumulating evidence indicates that H2S exhibits bimodal modulation of cancer development.Thus,endogenous or low levels of exogenous H2S are thought to promote cancer,whereas high doses of exogenous H2S suppress tumor proliferation.Similarly,inhibition of endogenous H2S production also suppresses tumor proliferation.Accordingly,H2S biosynthesis inhibitors and H2S supplementation(H2S donors)are two distinct strategies for the treatment of cancer.Unfortunately,modulation of endogenous H2S on pancreatic cancer has not been studied so far.However,H2S donors and their derivatives have been extensively studied as potential therapeutic agents for pancreatic cancer therapy by inhibiting cell proliferation,inducing apoptosis,arresting cell cycle,and suppressing invasion and migration through exploiting multiple signaling pathways.As far as we know,there is no review of the effects of H2S donors on pancreatic cancer.Based on these concerns,the therapeutic effects of some H2S donors and NO-H2S dual donors on pancreatic cancer were summarized in this paper.Exogenous H2S donors may be promising compounds for pancreatic cancer treatment.
