针对移动传感器网络节点定位算法的安全性问题,分析了虫洞攻击对MMCL算法的影响。为抵御虫洞攻击,改善定位性能,提出了一种基于标签的抗虫洞MMCL算法LB-MMCL(Label-Based Multi-hop Monte Carlo Localization)。该算法基于节点邻居列表...针对移动传感器网络节点定位算法的安全性问题,分析了虫洞攻击对MMCL算法的影响。为抵御虫洞攻击,改善定位性能,提出了一种基于标签的抗虫洞MMCL算法LB-MMCL(Label-Based Multi-hop Monte Carlo Localization)。该算法基于节点邻居列表中的异常,依据距离约束机制和消息唯一性原则,标记并区分虫洞两端受攻击的节点,断开虚假链路,以减轻虫洞攻击的影响,达到抵御攻击的目的。仿真结果表明,在无需额外硬件辅助下,LB-MMCL算法能有效抵御虫洞攻击,改善节点定位精度和定位率。展开更多
Objective To investigate the role of CXC chemokine receptor 3 (CXCR3) in bleomycin-induced lung injury by using CXCR3 gene deficient mice. Methods Sex-, age-, and weight-matched C57BL/6 CXCR3 gene knockout mice and C5...Objective To investigate the role of CXC chemokine receptor 3 (CXCR3) in bleomycin-induced lung injury by using CXCR3 gene deficient mice. Methods Sex-, age-, and weight-matched C57BL/6 CXCR3 gene knockout mice and C57BL/6 wide type mice were challenged by injection of bleomycin via trachea. Lung tissue was stained with HE method. Airway resistance was measured. Bronchoalveolar lavage (BAL) was performed using phosphate buffered saline twice, cell number and differentials were counted by Diff-Quick staining. Interleukin(IL)-4, IL-5, IL-12p40, and interfon-γ in BAL fluid and lung homogenate were measured by enzyme-linked immunosorbent assay. Unpaired t test was explored to compare the difference between two groups. Results On day 7 after bleomycin injection via trachea, CXCR3 knockout mice were protected from bleomycin-induced lung injury as evidenced by fewer accumulation of inflammatory cells in the airway and lung interstitium compared with their wild type littermates (P<0.05). Airway resistance was also lower in CXCR3 knockout mice compared with wild type mice (P<0.01). Significantly lower level of inflammatory cytokines release, including the altered production of IL-4 and IL-5 both in BAL fluid and lung tissue was seen in CXCR3 knockout mice than in wild type mice (both P<0.05).Conclusion CXCR3 signaling promotes inflammatory cells recruiting and initiates inflammatory cytokines cascade following endotracheal bleomycin administration, indicating that CXCR3 might be a therapeutic target for pulmonary injury.展开更多
A 47-year-old male(Patient A)passenger from Vietnam whose nucleic acid results for coronavirus disease 2019(COVID-19),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were positive at Pingxian...A 47-year-old male(Patient A)passenger from Vietnam whose nucleic acid results for coronavirus disease 2019(COVID-19),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were positive at Pingxiang Customs on April 29,2021,and subsequently confirmed by Guangxi CDC laboratories on April 30.展开更多
文摘针对移动传感器网络节点定位算法的安全性问题,分析了虫洞攻击对MMCL算法的影响。为抵御虫洞攻击,改善定位性能,提出了一种基于标签的抗虫洞MMCL算法LB-MMCL(Label-Based Multi-hop Monte Carlo Localization)。该算法基于节点邻居列表中的异常,依据距离约束机制和消息唯一性原则,标记并区分虫洞两端受攻击的节点,断开虚假链路,以减轻虫洞攻击的影响,达到抵御攻击的目的。仿真结果表明,在无需额外硬件辅助下,LB-MMCL算法能有效抵御虫洞攻击,改善节点定位精度和定位率。
基金Supported by the National Natural Sciences Foundation of China(30470767,30470768)
文摘Objective To investigate the role of CXC chemokine receptor 3 (CXCR3) in bleomycin-induced lung injury by using CXCR3 gene deficient mice. Methods Sex-, age-, and weight-matched C57BL/6 CXCR3 gene knockout mice and C57BL/6 wide type mice were challenged by injection of bleomycin via trachea. Lung tissue was stained with HE method. Airway resistance was measured. Bronchoalveolar lavage (BAL) was performed using phosphate buffered saline twice, cell number and differentials were counted by Diff-Quick staining. Interleukin(IL)-4, IL-5, IL-12p40, and interfon-γ in BAL fluid and lung homogenate were measured by enzyme-linked immunosorbent assay. Unpaired t test was explored to compare the difference between two groups. Results On day 7 after bleomycin injection via trachea, CXCR3 knockout mice were protected from bleomycin-induced lung injury as evidenced by fewer accumulation of inflammatory cells in the airway and lung interstitium compared with their wild type littermates (P<0.05). Airway resistance was also lower in CXCR3 knockout mice compared with wild type mice (P<0.01). Significantly lower level of inflammatory cytokines release, including the altered production of IL-4 and IL-5 both in BAL fluid and lung tissue was seen in CXCR3 knockout mice than in wild type mice (both P<0.05).Conclusion CXCR3 signaling promotes inflammatory cells recruiting and initiates inflammatory cytokines cascade following endotracheal bleomycin administration, indicating that CXCR3 might be a therapeutic target for pulmonary injury.
基金Guangxi Key Technologies Research and Development Program(Grant No.AB20149001).
文摘A 47-year-old male(Patient A)passenger from Vietnam whose nucleic acid results for coronavirus disease 2019(COVID-19),also known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),were positive at Pingxiang Customs on April 29,2021,and subsequently confirmed by Guangxi CDC laboratories on April 30.
