In deriving the physical properties of asteroids from their photometric data, the scattering law plays an important role, although the shape variations of asteroids result in the main variations in lightcurves. By fol...In deriving the physical properties of asteroids from their photometric data, the scattering law plays an important role, although the shape variations of asteroids result in the main variations in lightcurves. By following the physical behaviors of light reflections, Hapke et al. deduced complex functions to represent the scattering process, however, it is very hard to accurately simulate the surface scattering law in reality. For simplicity, other numerical scattering models are presented for efficiently calculating the physical properties of asteroids, such as the Lommel-Seeliger （LS） model. In this article, these two models are compared numerically. It is found that in some numerical applications the LS model in simple form with four parameters can be exploited to replace the Hapke model in complex form with five parameters. Furthermore, the generated synthetic lightcurves by the Cellinoid shape model also show that the LS model can perform as well as the Hapke model in the inversion process. Finally, by applying the Principal Component Analysis （PCA） technique to the parameters of the LS model, we present an efficient method to classify C and S type asteroids, instead of the conventional method using the parameters of the Hapke model.展开更多
Yes相关蛋白1(YAP1)是一种连接蛋白和转录共激活因子。YAP1作为Hippo信号通路的节点因子,通过发生级联磷酸化反应,实现对Hippo信号通路的响应,以此调节细胞增殖和凋亡,影响器官大小。为了解YAP1在牦牛乳腺组织生长发育和退化过程中的作...Yes相关蛋白1(YAP1)是一种连接蛋白和转录共激活因子。YAP1作为Hippo信号通路的节点因子,通过发生级联磷酸化反应,实现对Hippo信号通路的响应,以此调节细胞增殖和凋亡,影响器官大小。为了解YAP1在牦牛乳腺组织生长发育和退化过程中的作用,采集处于不同发育时期(妊娠期、泌乳期、干奶期)牦牛乳腺组织样品,采用qRT-PCR、Western-blot和免疫组织化学等技术检测YAP1基因及其蛋白的相对表达情况。结果显示,妊娠期牦牛乳腺组织中YAP1 m RNA表达量显著高于泌乳期和干奶期(P<0.05),且干奶期YAP1 m RNA表达量显著高于泌乳期(P<0.05)。在牦牛乳腺不同发育时期,YAP1蛋白也发生了显著变化,妊娠期和泌乳期YAP1蛋白表达量显著高于干奶期(P<0.05)。免疫组织化学定位显示,YAP1蛋白主要分布在牦牛乳腺导管上皮细胞和乳腺腺泡上皮细胞。上述结果表明,YAP1及其编码m RNA的差异表达可能是促进乳腺生长发育所必需的,YAP1分子可能主要以自分泌或旁分泌的方式在乳腺组织发育过程中发挥重要调节作用。本研究为进一步探明YAP1在乳腺生长发育调控中的作用提供参考依据,并为探究Hippo信号通路在调控乳腺体积中所发挥的功能积累了基础资料。展开更多
固醇调节元件结合蛋白1(Sterol regulatory element binding protein,SREBP1)作为一种核转录因子,与哺乳动物体内胆固醇及脂肪的生成密切相关。为了解牦牛乳腺组织中乳脂合成的机制及其特点,采集处于不同生理状态下(妊娠期、泌乳期、干...固醇调节元件结合蛋白1(Sterol regulatory element binding protein,SREBP1)作为一种核转录因子,与哺乳动物体内胆固醇及脂肪的生成密切相关。为了解牦牛乳腺组织中乳脂合成的机制及其特点,采集处于不同生理状态下(妊娠期、泌乳期、干奶期)的乳腺组织样品,采用qRT-PCR、Western-blot及免疫组化(immunohistochemistry,IHC)等技术检测SREBP1基因及其蛋白的相对表达情况。结果显示,泌乳期牦牛乳腺组织中SREBP1 m RNA表达量显著高于妊娠期和干奶期(P<0.05),且妊娠期SREBP1 m RNA表达量高于干奶期(P<0.05)。在牦牛不同生理状态下,SREBP1蛋白表达也发生了显著变化,妊娠期和泌乳期SREBP1蛋白表达量显著高于干奶期(P<0.05)。免疫组化法定位检测结果显示,SREBP1蛋白主要分布在牦牛乳腺腺泡上皮细胞、乳腺导管上皮细胞及血管内皮细胞。上述结果表明SREBP1及其编码m RNA的表达在牦牛乳腺组织中与其所处不同生理状态密切相关,妊娠期和泌乳期SREBP1的高表达,可能意味着其在牦牛乳腺发育和乳脂合成的过程中发挥着重要作用。本研究为进一步探明SREBP1在牦牛乳脂合成调控中的作用积累了一些基础资料。展开更多
基金funded under grant Nos. 095/2013/A3 and 039/2013/A2 from the Science and Technology Development Fundsupported partly by the Key Laboratory of Planetary Sciences+2 种基金supported by the MSAR Science and Technology Fund (Project No. 017/2014/A1)support of the National Natural Science Foundation of China (Grant Nos. 11633009, 11273067 and 10503013)the Minor Planet Foundation of Purple Mountain Observatory
文摘In deriving the physical properties of asteroids from their photometric data, the scattering law plays an important role, although the shape variations of asteroids result in the main variations in lightcurves. By following the physical behaviors of light reflections, Hapke et al. deduced complex functions to represent the scattering process, however, it is very hard to accurately simulate the surface scattering law in reality. For simplicity, other numerical scattering models are presented for efficiently calculating the physical properties of asteroids, such as the Lommel-Seeliger （LS） model. In this article, these two models are compared numerically. It is found that in some numerical applications the LS model in simple form with four parameters can be exploited to replace the Hapke model in complex form with five parameters. Furthermore, the generated synthetic lightcurves by the Cellinoid shape model also show that the LS model can perform as well as the Hapke model in the inversion process. Finally, by applying the Principal Component Analysis （PCA） technique to the parameters of the LS model, we present an efficient method to classify C and S type asteroids, instead of the conventional method using the parameters of the Hapke model.
文摘Yes相关蛋白1(YAP1)是一种连接蛋白和转录共激活因子。YAP1作为Hippo信号通路的节点因子,通过发生级联磷酸化反应,实现对Hippo信号通路的响应,以此调节细胞增殖和凋亡,影响器官大小。为了解YAP1在牦牛乳腺组织生长发育和退化过程中的作用,采集处于不同发育时期(妊娠期、泌乳期、干奶期)牦牛乳腺组织样品,采用qRT-PCR、Western-blot和免疫组织化学等技术检测YAP1基因及其蛋白的相对表达情况。结果显示,妊娠期牦牛乳腺组织中YAP1 m RNA表达量显著高于泌乳期和干奶期(P<0.05),且干奶期YAP1 m RNA表达量显著高于泌乳期(P<0.05)。在牦牛乳腺不同发育时期,YAP1蛋白也发生了显著变化,妊娠期和泌乳期YAP1蛋白表达量显著高于干奶期(P<0.05)。免疫组织化学定位显示,YAP1蛋白主要分布在牦牛乳腺导管上皮细胞和乳腺腺泡上皮细胞。上述结果表明,YAP1及其编码m RNA的差异表达可能是促进乳腺生长发育所必需的,YAP1分子可能主要以自分泌或旁分泌的方式在乳腺组织发育过程中发挥重要调节作用。本研究为进一步探明YAP1在乳腺生长发育调控中的作用提供参考依据,并为探究Hippo信号通路在调控乳腺体积中所发挥的功能积累了基础资料。
文摘固醇调节元件结合蛋白1(Sterol regulatory element binding protein,SREBP1)作为一种核转录因子,与哺乳动物体内胆固醇及脂肪的生成密切相关。为了解牦牛乳腺组织中乳脂合成的机制及其特点,采集处于不同生理状态下(妊娠期、泌乳期、干奶期)的乳腺组织样品,采用qRT-PCR、Western-blot及免疫组化(immunohistochemistry,IHC)等技术检测SREBP1基因及其蛋白的相对表达情况。结果显示,泌乳期牦牛乳腺组织中SREBP1 m RNA表达量显著高于妊娠期和干奶期(P<0.05),且妊娠期SREBP1 m RNA表达量高于干奶期(P<0.05)。在牦牛不同生理状态下,SREBP1蛋白表达也发生了显著变化,妊娠期和泌乳期SREBP1蛋白表达量显著高于干奶期(P<0.05)。免疫组化法定位检测结果显示,SREBP1蛋白主要分布在牦牛乳腺腺泡上皮细胞、乳腺导管上皮细胞及血管内皮细胞。上述结果表明SREBP1及其编码m RNA的表达在牦牛乳腺组织中与其所处不同生理状态密切相关,妊娠期和泌乳期SREBP1的高表达,可能意味着其在牦牛乳腺发育和乳脂合成的过程中发挥着重要作用。本研究为进一步探明SREBP1在牦牛乳脂合成调控中的作用积累了一些基础资料。
