Canrenone（1） was biotransformed into 11α-hydroxycanrenone（2） and a main byproduct（3） by Aspergillus ochraceus SIT34205.Compound 3 was separated and purified using silica gel column chromatography,and its struct...Canrenone（1） was biotransformed into 11α-hydroxycanrenone（2） and a main byproduct（3） by Aspergillus ochraceus SIT34205.Compound 3 was separated and purified using silica gel column chromatography,and its structure was characterized via MS and NMR methods.These results indicated that 3 was 1β,11α-dihydroxycanrenone and the product of further hydroxylation of 2.Thus,investigating the structure and synthesis of 3 may be a promising method to improve the efficiency and purity of 2.展开更多
文摘Canrenone（1） was biotransformed into 11α-hydroxycanrenone（2） and a main byproduct（3） by Aspergillus ochraceus SIT34205.Compound 3 was separated and purified using silica gel column chromatography,and its structure was characterized via MS and NMR methods.These results indicated that 3 was 1β,11α-dihydroxycanrenone and the product of further hydroxylation of 2.Thus,investigating the structure and synthesis of 3 may be a promising method to improve the efficiency and purity of 2.
