化脓性链球菌即A组链球菌(group A Streptococcus,GAS)作为成人社区获得性肺炎的病原体并不常见,临床上易被忽视而漏诊。本文报道1例青年男性因急性化脓性扁桃体炎治疗不规范引发肺炎,病原菌为GAS,伴抗链球菌溶血素O(Antistreptolysin O...化脓性链球菌即A组链球菌(group A Streptococcus,GAS)作为成人社区获得性肺炎的病原体并不常见,临床上易被忽视而漏诊。本文报道1例青年男性因急性化脓性扁桃体炎治疗不规范引发肺炎,病原菌为GAS,伴抗链球菌溶血素O(Antistreptolysin O,ASO)增高,予患者静脉注射万古霉素控制感染后,其ASO抗体滴度仍维持在高水平,遂序贯给予苄星青霉素肌肉注射每月1次,共5个月。之后随访6个月,患者未再有发热咽痛等症状,ASO水平正常,未出现风湿性多脏器损伤。近年,全球GAS感染仍有报道,且可引起一系列并发症,如风湿热、风湿性心脏病等,严重者可导致死亡。GAS感染的早诊、早治至关重要。展开更多
Background Idiopathic pulmonary fibrosis （IPF） is a progressive diffuse parenchymal disease with a poor prognosis.A variety of cytokines and chemokines are involved in its pathophysiology.The aim of this study was t...Background Idiopathic pulmonary fibrosis （IPF） is a progressive diffuse parenchymal disease with a poor prognosis.A variety of cytokines and chemokines are involved in its pathophysiology.The aim of this study was to evaluate the clinical features in IPF patients with the expression of suppressor of cytokine signaling 1 （SOCS-1）,which acts as a negative regulator of cytokine signaling.Methods IPF patients （n=20） and healthy controls （n=16） were included in this study.The expression of SOCS-1 was analyzed in peripheral blood mononuclear cells （PBMC） of subjects using RT-PCR.Interleukin 4 （IL-4）,transforming growth factor β1 （TGF-β1） and type Ⅰ collagen expression were also analyzed in each individual using enzyme-linked immunosorbent assay （ELISA）.The clinical characteristics of IPF patients were delineated.These results were analyzed by SPSS13.0 statistics software.Results SOCS-1 mRNA expression was significantly decreased in the PBMC of IPF patients compared with healthy controls; serum levels of IL-4 and TGF-β1 were higher in IPF patients.The patients with lower expression of SOCS-1 developed lower percentage of forced vital capacity （FVC%） and DLCO/VA.A patients＇ SOCS-1 mRNA level was negatively correlated with serum levels of IL-4,and negatively correlated with their high-resolution computed tomography （HRCT） scores.Conclusions SOCS-1 mRNA can be detected in PBMC,and it is down-regulated in IPF patients.The expression of SOCS-1 is associated with the severity of IPF patients＇ symptoms,so it might be the predictor of disease severity.SOCS-1 might play an important role in IPF by reducing the expression of the T helper type 2 （Th2） cell-related cytokine IL-4.展开更多
文摘化脓性链球菌即A组链球菌(group A Streptococcus,GAS)作为成人社区获得性肺炎的病原体并不常见,临床上易被忽视而漏诊。本文报道1例青年男性因急性化脓性扁桃体炎治疗不规范引发肺炎,病原菌为GAS,伴抗链球菌溶血素O(Antistreptolysin O,ASO)增高,予患者静脉注射万古霉素控制感染后,其ASO抗体滴度仍维持在高水平,遂序贯给予苄星青霉素肌肉注射每月1次,共5个月。之后随访6个月,患者未再有发热咽痛等症状,ASO水平正常,未出现风湿性多脏器损伤。近年,全球GAS感染仍有报道,且可引起一系列并发症,如风湿热、风湿性心脏病等,严重者可导致死亡。GAS感染的早诊、早治至关重要。
基金This study was supported by the grants from Science and Technology Commission of Shanghai，National Natural Science Foundation
文摘Background Idiopathic pulmonary fibrosis （IPF） is a progressive diffuse parenchymal disease with a poor prognosis.A variety of cytokines and chemokines are involved in its pathophysiology.The aim of this study was to evaluate the clinical features in IPF patients with the expression of suppressor of cytokine signaling 1 （SOCS-1）,which acts as a negative regulator of cytokine signaling.Methods IPF patients （n=20） and healthy controls （n=16） were included in this study.The expression of SOCS-1 was analyzed in peripheral blood mononuclear cells （PBMC） of subjects using RT-PCR.Interleukin 4 （IL-4）,transforming growth factor β1 （TGF-β1） and type Ⅰ collagen expression were also analyzed in each individual using enzyme-linked immunosorbent assay （ELISA）.The clinical characteristics of IPF patients were delineated.These results were analyzed by SPSS13.0 statistics software.Results SOCS-1 mRNA expression was significantly decreased in the PBMC of IPF patients compared with healthy controls; serum levels of IL-4 and TGF-β1 were higher in IPF patients.The patients with lower expression of SOCS-1 developed lower percentage of forced vital capacity （FVC%） and DLCO/VA.A patients＇ SOCS-1 mRNA level was negatively correlated with serum levels of IL-4,and negatively correlated with their high-resolution computed tomography （HRCT） scores.Conclusions SOCS-1 mRNA can be detected in PBMC,and it is down-regulated in IPF patients.The expression of SOCS-1 is associated with the severity of IPF patients＇ symptoms,so it might be the predictor of disease severity.SOCS-1 might play an important role in IPF by reducing the expression of the T helper type 2 （Th2） cell-related cytokine IL-4.
