Herein,we report an efficient photochemical method for the synthesis of poly-substituted pyrazoles through a multicomponent reaction of acceptor-only diazoalkanes,alkynes,and solvents(cyclic ethers or nitriles).The ke...Herein,we report an efficient photochemical method for the synthesis of poly-substituted pyrazoles through a multicomponent reaction of acceptor-only diazoalkanes,alkynes,and solvents(cyclic ethers or nitriles).The key to this success was driven by the photolysis of acceptor-only diazoalkanes to form free carbene species and the fast in situ[3+2]-cycloaddition formation of nucleophilic N–H pyrazole derivatives.This work also serves as an entry to allow future reaction design on the combination of carbene reactivity of diazoalkanes with their other reaction modes.展开更多
Organophosphorus compounds have attracted continuous attention in materials science, agrochemical and pharmaceutical fields due to their unique bioactivities. Thus, the development of novel and robust manners for the ...Organophosphorus compounds have attracted continuous attention in materials science, agrochemical and pharmaceutical fields due to their unique bioactivities. Thus, the development of novel and robust manners for the construction new C—P bond has therefore gained great interests in synthetic organic chemistry. Because of their intrinsic sustainability and green chemistry character, visible light-induced photoredox catalysis has been widely applied in the construction of new chemical bonds, including the formation of C—P bond. In this review, we summarized recent achievements in C—P bond formation reactions initiated by visible light-induced photoredox catalysis, which mainly focusing on the discussion of reaction design and the mechanism.展开更多
A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed.This method utilized visible light as the sole and clean ene...A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed.This method utilized visible light as the sole and clean energy source without the need for an exogenous photoredox catalyst or additive.Moreover,nitrones are generated in situ,bypassing the isolation process and producing only nitrogen gas as a byproduct.The synthetic value of this protocol has potential applications in the syntheses of amides containing important natural products and drugbased complex molecules.展开更多
基金the National Natural Science Foundation of China(Nos.21971001 and 21702001)the Natural Science Foundation of Anhui Province(No.1808085MB47),for financial support。
文摘Herein,we report an efficient photochemical method for the synthesis of poly-substituted pyrazoles through a multicomponent reaction of acceptor-only diazoalkanes,alkynes,and solvents(cyclic ethers or nitriles).The key to this success was driven by the photolysis of acceptor-only diazoalkanes to form free carbene species and the fast in situ[3+2]-cycloaddition formation of nucleophilic N–H pyrazole derivatives.This work also serves as an entry to allow future reaction design on the combination of carbene reactivity of diazoalkanes with their other reaction modes.
基金supported by the National Natural Science Foundation of China(21702001)Open fund for Institute of Physical Science and Information Technology,Anhui University and the Start-up Grant from Anhui University
文摘Organophosphorus compounds have attracted continuous attention in materials science, agrochemical and pharmaceutical fields due to their unique bioactivities. Thus, the development of novel and robust manners for the construction new C—P bond has therefore gained great interests in synthetic organic chemistry. Because of their intrinsic sustainability and green chemistry character, visible light-induced photoredox catalysis has been widely applied in the construction of new chemical bonds, including the formation of C—P bond. In this review, we summarized recent achievements in C—P bond formation reactions initiated by visible light-induced photoredox catalysis, which mainly focusing on the discussion of reaction design and the mechanism.
基金The authors acknowledge the National Natural Science Foundation of China(nos.21971001 and 21702001)the Start-up Grant from Anhui University for financial support of this work.
文摘A green and sustainable synthetic strategy for amide bond formation utilizing a visible light-promoted nitrone formation/rearrangement cascade was developed.This method utilized visible light as the sole and clean energy source without the need for an exogenous photoredox catalyst or additive.Moreover,nitrones are generated in situ,bypassing the isolation process and producing only nitrogen gas as a byproduct.The synthetic value of this protocol has potential applications in the syntheses of amides containing important natural products and drugbased complex molecules.
