The copper polymetallic deposits and resource potential in the Tibet Plateau

Many large and super-large copper deposits have been discovered and explored in the Tibet Plateau,which makes it the most important copper resource reserve and development base in China.Based on the work of the research team,the paper summarizes the geological characteristics of the main copper deposits in Tibet and puts forward a further prospecting direction.A series of large accumulated metal deposits or ore districts from subduction of Tethys oceanic crust to India-Asia collisionhave been discovered,such as Duolong Cu(Au)ore district and Jiama copper polymetallic deposit.The ore deposits in the Duolong ore district are located in the lowstand domain,the top of lowstand domain,and the highstand domain of the same magmatic-hydrothermal metallogenic system,and their relative positions are the indicators for related deposits in the Bangong Co-Nujiang metallogenic belt.The polycentric metallogenic model of the Jiama copper polymetallic deposit is an important inspiration for the exploration of the porphyry mineralization related to collision orogeny.Further mineral exploration in the Tibet Plateau should be focused on the continental volcanic rocks related to porphyry-epithermal deposits,orogenic gold deposits,hydrothermal Pb-Zn deposits related to nappe structures,skarn Cu(Au)and polymetallic deposits,and the Miocene W-Sn polymetallic deposits.

Clinical study of warm acupuncture combined with massage in treatment of periathritis of shoulder

Objective: To analyze the clinical efficacy of warm acupuncture and moxibustion combined with manipulation in the treatment of periarthritis of shoulder. Methods: In this study, 120 patients with periarthritis of shoulder who were admitted to the department of orthopedics of the second affiliated hospital of Heilongjiang university of traditional Chinese medicine from June 2018 to June 2019 were selected, and the patients were divided into warm acupuncture group, massage group, combined treatment group and control group with a random number table, with 30 patients in each group. Warm acupuncture and moxibustion group received 4 weeks of warm acupuncture and moxibustion treatment, massage group received 4 weeks of massage treatment, patients in the combined treatment group received 4 weeks of warm acupuncture and moxibustion treatment, patients in the control group received 4 weeks of ultrashort wave combined plaster treatment. The use of ibuprofen, VAS score, Melle score, TCM syndrome score and serum inflammatory factors before and after treatment were analyzed and compared in each group of patients to evaluate the clinical efficacy. Results:shoulder joint pain and activity limitation were significantly improved in each group, VAS score, Melle score, TCM syndrome score and serum inflammatory factor levels were significantly decreased compared with before treatment (P < 0.05), and the improvement in the combined treatment group was significantly better than that in other groups (P < 0.05). Conclusion: Warm acupuncture combined with manipulation can significantly improve the clinical symptoms of periarthritis of shoulder, improve the mobility of shoulder joint, and inhibit the internal inflammatory response, which is significantly better than using warm acupuncture or manipulation alone and conventional physical therapy.

Guidance on home rehabilitation in Chinese and Western medicine to prevent the relapse of novel coronavirus disease-19 pneumonia after recovery

Patients with novel coronavirus disease-19(COVID-19)pneumonia continue to have problems with respiratory function,physical and psychological function,the ability to perform activities of daily living,and social participation after discharge from the hospital.As such,strengthening rehabilitation treatments for discharged patients and relapse prevention after recovery are important aspects of the prevention and control of COVID-19.This paper combined the principles and practices of in Chinese and Western medicine and compiled the recommendations of both for home rehabilitation in the post-COVID-19 epidemic stage.The purpose of this paper is to facilitate the self-rehabilitation of patients with COVID-19 and to promote the prevention and control of COVID-19 at this current stage.

Simulated aeromedical evacuation exacerbates burn induced lung injury:targeting mitochondrial DNA for reversal

Background:Aeromedical evacuation of patients with burn trauma is an important transport method in times of peace and war,during which patients are exposed to prolonged periods of hypobaric hypoxia;however,the effects of such exposure on burn injuries,particularly on burn-induced lung injuries,are largely unexplored.This study aimed to determine the effects of hypobaric hypoxia on burn-induced lung injuries and to investigate the underlying mechanism using a rat burn model.Methods:A total of 40 male Wistar rats were randomly divided into four groups(10 in each group):sham burn(SB)group,burn in normoxia condition(BN)group,burn in hypoxia condition(BH)group,and burn in hypoxia condition with treatment intervention(BHD)group.Rats with 30%total body surface area burns were exposed to hypobaric hypoxia(2000 m altitude simulation)or normoxia conditions for 4 h.Deoxyribonuclease I(DNase I)was administered systemically as a treatment intervention.Systemic inflammatory mediator and mitochondrial deoxyribonucleic acid(mtDNA)levels were determined.A histopathological evaluation was performed and the acute lung injury(ALI)score was determined.Malonaldehyde(MDA)content,myeloperoxidase(MPO)activity,and the nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3(NLRP3)inflammasome level were determined in lung tissues.Data among groups were compared using analysis of variance followed by Tukey’s test post hoc analysis.Results:Burns resulted in a remarkably higher level of systemic inflammatory cytokines and mtDNA release,which was further heightened by hypobaric hypoxia exposure(P<0.01).Moreover,hypobaric hypoxia exposure gave rise to increased NLRP3 inflammasome expression,MDA content,and MPO activity in the lung(P<0.05 or P<0.01).Burn-induced lung injuries were exacerbated,as shown by the histopathological evaluation and ALI score(P<0.01).Administration of DNase I markedly reduced mtDNA release and systemic inflammatory cytokine production.Furthermore,the NLRP3 inflammasome level in lung tissues was decreased and burn-induced lung injury was ameliorated(P<0.01).Conclusions:Our results suggested that simulated aeromedical evacuation further increased burn-induced mtDNA release and exacerbated burn-induced inflammation and lung injury.DNase I reduced the release of mtDNA,limited mtDNA-induced systemic inflammation,and ameliorated burn-induced ALI.The intervening mtDNA level is thus a potential target to protect from burn-induced lung injury during aeromedical conditions and provides safer air evacuations for severely burned patients.

基于找形模型研究微丝束对细胞骨架刚度的影响(英文)

研究目的:基于找形分析建立的细胞骨架力学模型研究微丝束对细胞骨架刚度的影响。创新要点:目前存在的细胞模型很少考虑微丝束对细胞力学特性的重要作用。本文基于细胞找形模型模拟了同时包含微丝和微丝束的细胞骨架网络结构,并且分析了细胞中微丝束的排列方向、微丝束的含量以及微丝波动对细胞刚度的影响。研究方法:基于找形模型,随机生成由微丝、微丝束(梁单元)以及交联蛋白(索单元)形成的细胞骨架网络结构,依靠非线性有限元计算和样本统计,计算出模型的弹性模量。通过分别改变模型中微丝束的排列方向、微丝束的含量以及模型初始最大位移等参数,得出细胞骨架模型的弹性模量随这些参数的变化趋势,以此来研究微丝束对细胞刚度的影响。重要结论:细胞骨架网络中微丝的波动会导致细胞刚度降低;与拉伸方向平行排列的微丝束可以显著地提高细胞的刚度,相比之下随机分布的微丝束对细胞刚度没有贡献;在微丝材料总量固定的情况下,细胞刚度随着平行排列微丝束含量的增加呈现出先升高后降低的趋势。