Osteoarthritis(OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective diseasemodifying therapy. Here, we report that elevated cyclooxygenase-2(COX-2) expression ...Osteoarthritis(OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective diseasemodifying therapy. Here, we report that elevated cyclooxygenase-2(COX-2) expression in the osteocytes of subchondral bone causes both spontaneous OA and rheumatoid arthritis(RA). The knockout of COX-2 in osteocytes or treatment with a COX-2 inhibitor effectively rescues the structure of subchondral bone and attenuates cartilage degeneration in spontaneous OA(STR/Ort)mice and tumor necrosis factor-α transgenic RA mice. Thus, elevated COX-2 expression in subchondral bone induces both OAassociated and RA-associated joint cartilage degeneration. The inhibition of COX-2 expression can potentially modify joint destruction in patients with arthritis.展开更多
Restoring proper lower limb alignment on the coronal plane after total knee arthroplasty(TKA)can decrease stress in the bone cement-implant interface,polyethylene wear,and implant loosening.Weight-bearing long-leg rad...Restoring proper lower limb alignment on the coronal plane after total knee arthroplasty(TKA)can decrease stress in the bone cement-implant interface,polyethylene wear,and implant loosening.Weight-bearing long-leg radiographs(LLRs)are used to assess the mechanical axis in the coronal plane,identify anatomic variations in the femur and tibia,and plan the degree of bone resection preoperatively.However,rotation or flexion of the lower limb may affect the accuracy of the measurement of alignment parameters from LLRs.Furthermore,known rotation-dependent linear changes can be used to relate the degree of lower limb rotation to the alignment parameters of the femur and tibia and the hip-knee-ankle(HKA)angle[1].展开更多
基金supported by the NIH/NIAMS grants AR071432 and AR063943 (to X.C.)
文摘Osteoarthritis(OA) causes the destruction of joints. Its pathogenesis is still under investigation, and there is no effective diseasemodifying therapy. Here, we report that elevated cyclooxygenase-2(COX-2) expression in the osteocytes of subchondral bone causes both spontaneous OA and rheumatoid arthritis(RA). The knockout of COX-2 in osteocytes or treatment with a COX-2 inhibitor effectively rescues the structure of subchondral bone and attenuates cartilage degeneration in spontaneous OA(STR/Ort)mice and tumor necrosis factor-α transgenic RA mice. Thus, elevated COX-2 expression in subchondral bone induces both OAassociated and RA-associated joint cartilage degeneration. The inhibition of COX-2 expression can potentially modify joint destruction in patients with arthritis.
文摘Restoring proper lower limb alignment on the coronal plane after total knee arthroplasty(TKA)can decrease stress in the bone cement-implant interface,polyethylene wear,and implant loosening.Weight-bearing long-leg radiographs(LLRs)are used to assess the mechanical axis in the coronal plane,identify anatomic variations in the femur and tibia,and plan the degree of bone resection preoperatively.However,rotation or flexion of the lower limb may affect the accuracy of the measurement of alignment parameters from LLRs.Furthermore,known rotation-dependent linear changes can be used to relate the degree of lower limb rotation to the alignment parameters of the femur and tibia and the hip-knee-ankle(HKA)angle[1].
