Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inf...Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord.In this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites.The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier.Arctigenin,a Chinese herbal medicine,was loaded into the nanosystem to reduce inflammation.The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site.Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of SCI.Our study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy.展开更多
The variation in altitude density function （ADF） of the surface topography of mild steel during electrochemical polishing （ECP） was investigated, and the mechanism of the variation of surface roughness with polish...The variation in altitude density function （ADF） of the surface topography of mild steel during electrochemical polishing （ECP） was investigated, and the mechanism of the variation of surface roughness with polishing time was analyzed. The results show that the variation trend of ADF with polishing time is flat-steep-flat; the variation of surface roughness results in the different distri- butions of surface current density, and there is a fine surface smoothness in the special period of ECP from 4 to 8 s.展开更多
In order to inspect the good and reliability of automated charging station’s lightning protection design in airport, we set the comprehensive evaluation mathematical model of automated charging station in the airport...In order to inspect the good and reliability of automated charging station’s lightning protection design in airport, we set the comprehensive evaluation mathematical model of automated charging station in the airport, through the method of second order fuzzy comprehensive evaluation and evaluate the automated charging station’s lightning protection design comprehensively by using the assessment data of expert database.展开更多
Generator control system decides whether the generator can work as usual or not, as well as its stability of performance. Both types of generators control system composed of the transistor and DSP are sensitive to out...Generator control system decides whether the generator can work as usual or not, as well as its stability of performance. Both types of generators control system composed of the transistor and DSP are sensitive to outward electromagnetic interference, directly related to the generator performance. In this text, we first analyze the electromagnetic interference threat generator control system of transistor type may face, then design a electromagnetic protection plan for the intake, the panel and the sense organ. This work is of great significance in improving its electromagnetic protection ability and stability of performance.展开更多
As a widely used security device,the electronic passworded locker is designed to protect personal property and space.However,once the password is leaked to an unauthorized person,its security is lost.Here,with the ass...As a widely used security device,the electronic passworded locker is designed to protect personal property and space.However,once the password is leaked to an unauthorized person,its security is lost.Here,with the assistance of triboelectric nanogenerators(TENGs),we present an intelligent electronic passworded locker(IEPL)based on unique and personalized security barriers,which can accurately extract users’habits of entering passwords through integrated deep learning.The key of the IEPL adopts the single electrode mode of TENG that accurately recognizes the input behavior of a person based on machine learning,which serves as a reliable,unique,unreproducible gate,with advantages of thin thickness,diversified structure,and simple preparation method.Finally,the proposed IEPL offers a reliable solution for improving the overall security of passworded lockers and extending the application of TENG-based sensors in the smart home.展开更多
An interesting inverter topology is proposed in this paper.It is similar to the typical three-phase full bridge inverter from the topology point of view,but smartly designed for the ground current reduction in single-...An interesting inverter topology is proposed in this paper.It is similar to the typical three-phase full bridge inverter from the topology point of view,but smartly designed for the ground current reduction in single-phase photovoltaic(PV)inverter applications.Theoretical analysis is conducted to clarify the operation mechanism of the proposed topology.Performance evaluation is carried out to verify the effectiveness of the proposed topology for the ground current suppression.展开更多
The theft prevention for cultural relics in museums,field excavation sites,and temporary exhibition events is of extreme importance.However,traditional anti-theft technologies such as infrared monitoring and radio fre...The theft prevention for cultural relics in museums,field excavation sites,and temporary exhibition events is of extreme importance.However,traditional anti-theft technologies such as infrared monitoring and radio frequency identification are highly costly,power-consuming,and easy to break.Here,a transparent,ultrathin,and flexible triboelectric sensor(TUFS)with a simple and low-cost method is proposed.With a thickness,weight,and transmittance of 92μm,0.12 g,and 89.4%,the TUFS manifests superb concealment.Benefiting from the characteristic of triboelectric nanogenerators,the TUFS responds effectively to common cultural-relic materials.Moreover,distinguished electrical responses can be obtained even for very small weights(10 g)and areas(1 cm^(2)),proving the sensitivity and wide range of use of the TUFS.Finally,we construct a concealed cultural-relic anti-theft system that enables real-time alarming and accurate positioning of cultural relics,which is expected to strengthen the security level of the existing museum anti-theft systems.展开更多
Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue...Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI.展开更多
Integrating the electric vehicle into grid or microgrid has been receiving more and more attention in recent years.Typically,the electric vehicle(EV)chargers with their power batteries have been developed for vehicle-...Integrating the electric vehicle into grid or microgrid has been receiving more and more attention in recent years.Typically,the electric vehicle(EV)chargers with their power batteries have been developed for vehicle-to-home(V2H)applications,acting as a backup generation to supply emergency power directly to a home.Traditional EV chargers in V2H applications mainly consist of DC/DC and DC/AC stages,which complicate the control algorithm and result in low conversion efficiency.In order to solve this problem,a novel EV charger is proposed for V2H applications.It can boost the battery voltage and output AC voltage with only one-stage power conversion.Also,the DC,1-phase and 3-phase loads can be fed with the proposed single-stage EV charger.The system control strategy is also provided to deal with versatile load variations.Finally,the performance evaluation results verify the effectiveness of the proposed solution.展开更多
基金supported by the National Natural Science Foundation of China(Nos.31670969,51302089,and 31571030)the Fundamental Research Funds for the Central Universities(No.21617428)+3 种基金Key Program of Traditional Chinese Medicine of Guangdong Province(No.20173018)The Science and Technology Program of Jiangmen City of China(No.2017A2004)Natural Science Foundation of Guangdong Province(No.2018A030313576)Science and Technology Program of Guangzhou(No.201803010001)
文摘Acute inflammation is a central component in the progression of spinal cord injury(SCI).Anti-inflammatory drugs used in the clinic are often administered systemically at high doses,which can paradoxically increase inflammation and result in drug toxicity.A cluster-like mesoporous silica/arctigenin/CAQK composite(MSN-FC@ARCG)drug delivery system was designed to avoid systemic side effects of high-dose therapy by enabling site-specific drug delivery to the spinal cord.In this nanosystem,mesoporous silica was modified with the FITC fluorescent molecule and CAQK peptides that target brain injury and SCI sites.The size of the nanocarrier was kept at approximately 100 nm to enable penetration of the blood–brain barrier.Arctigenin,a Chinese herbal medicine,was loaded into the nanosystem to reduce inflammation.The in vivo results showed that MSN-FC@ARC-G could attenuate inflammation at the injury site.Behavior and morphology experiments suggested that MSN-FC@ARC-G could diminish local microenvironment damage,especially reducing the expression of interleukin-17(IL-17) and IL-17-related inflammatory factors,inhibiting the activation of astrocytes,thus protecting neurons and accelerating the recovery of SCI.Our study demonstrated that this novel,silica-based drug delivery system has promising potential for clinical application in SCI therapy.
基金the National Natural Science Foundation of China (No.59831030).
文摘The variation in altitude density function （ADF） of the surface topography of mild steel during electrochemical polishing （ECP） was investigated, and the mechanism of the variation of surface roughness with polishing time was analyzed. The results show that the variation trend of ADF with polishing time is flat-steep-flat; the variation of surface roughness results in the different distri- butions of surface current density, and there is a fine surface smoothness in the special period of ECP from 4 to 8 s.
文摘In order to inspect the good and reliability of automated charging station’s lightning protection design in airport, we set the comprehensive evaluation mathematical model of automated charging station in the airport, through the method of second order fuzzy comprehensive evaluation and evaluate the automated charging station’s lightning protection design comprehensively by using the assessment data of expert database.
文摘Generator control system decides whether the generator can work as usual or not, as well as its stability of performance. Both types of generators control system composed of the transistor and DSP are sensitive to outward electromagnetic interference, directly related to the generator performance. In this text, we first analyze the electromagnetic interference threat generator control system of transistor type may face, then design a electromagnetic protection plan for the intake, the panel and the sense organ. This work is of great significance in improving its electromagnetic protection ability and stability of performance.
基金the National Natural Science Foundation of China(No.61503051).
文摘As a widely used security device,the electronic passworded locker is designed to protect personal property and space.However,once the password is leaked to an unauthorized person,its security is lost.Here,with the assistance of triboelectric nanogenerators(TENGs),we present an intelligent electronic passworded locker(IEPL)based on unique and personalized security barriers,which can accurately extract users’habits of entering passwords through integrated deep learning.The key of the IEPL adopts the single electrode mode of TENG that accurately recognizes the input behavior of a person based on machine learning,which serves as a reliable,unique,unreproducible gate,with advantages of thin thickness,diversified structure,and simple preparation method.Finally,the proposed IEPL offers a reliable solution for improving the overall security of passworded lockers and extending the application of TENG-based sensors in the smart home.
基金This work was supported by the National Natural Science Foundation of China(51307149)China Postdoctoral Science Foundation(2014M551050)Specialized Research Fund for the Doctoral Program of Higher Education(20131333120016).
文摘An interesting inverter topology is proposed in this paper.It is similar to the typical three-phase full bridge inverter from the topology point of view,but smartly designed for the ground current reduction in single-phase photovoltaic(PV)inverter applications.Theoretical analysis is conducted to clarify the operation mechanism of the proposed topology.Performance evaluation is carried out to verify the effectiveness of the proposed topology for the ground current suppression.
基金the National Natural Science Foundation of China(No.61503051).
文摘The theft prevention for cultural relics in museums,field excavation sites,and temporary exhibition events is of extreme importance.However,traditional anti-theft technologies such as infrared monitoring and radio frequency identification are highly costly,power-consuming,and easy to break.Here,a transparent,ultrathin,and flexible triboelectric sensor(TUFS)with a simple and low-cost method is proposed.With a thickness,weight,and transmittance of 92μm,0.12 g,and 89.4%,the TUFS manifests superb concealment.Benefiting from the characteristic of triboelectric nanogenerators,the TUFS responds effectively to common cultural-relic materials.Moreover,distinguished electrical responses can be obtained even for very small weights(10 g)and areas(1 cm^(2)),proving the sensitivity and wide range of use of the TUFS.Finally,we construct a concealed cultural-relic anti-theft system that enables real-time alarming and accurate positioning of cultural relics,which is expected to strengthen the security level of the existing museum anti-theft systems.
基金supported by the National Natural Science Foundation of China (31470872 to YG and 31400770 to ZY)the ‘‘111” project (B16021 to YG and ZY)+5 种基金the Science and Technology Program of Guangzhou (201604020162 to YG)Science & Technology Planning and Key Technology Innovation Projects of Guangdong (201803010001 to ZL)the National Natural Science Foundation of Guangdong (2018A030313576 to GS)Traditional Chinese Medicine Bureau of Guangdong (20181071 to JH)the National Natural Science Foundation of China (31800721 to QW)Medical and Health Development Plan of Shandong Province (2017WS446 to LZ)
文摘Spinal cord injury(SCI) is a devastating traumatic injury that causes persistent, severe motor and sensory dysfunction. Immune responses are involved in functional recovery after SCI. Mucosa-associated lymphoid tissue lymphoma translocation 1(MALT1) has been shown to regulate the survival and differentiation of immune cells and to play a critical role in many diseases, but its function in lesion recovery after SCI remains unclear. In this paper, we generated KI(knock in) mice with a point mutation(C472 G) in the active center of MALT1 and found that the KI mice exhibited improved functional recovery after SCI.Fewer macrophages were recruited to the injury site in KI mice and these macrophages differentiated into anti-inflammatory macrophages. Moreover, macrophages from KI mice exhibited reduced phosphorylation of p65, which in turn resulted in decreased SOCS3 expression and increased pSTAT6 levels.Similar results were obtained upon inhibition of MALT1 paracaspase with the small molecule inhibitor‘‘MI-2' or the more specific inhibitor ‘‘MLT-827'. In patients with SCI, peripheral blood mononuclear cells(PBMC) displayed increased MALT1 paracaspase. Human macrophages showed reduced proinflammatory and increased anti-inflammatory characteristics following the inhibition of MALT1 paracaspase. These findings suggest that inhibition of MALT1 paracaspase activity in the clinic may improve lesion recovery in subjects with SCI.
基金This work was supported by the National Natural Science Foundation of China （Grant Nos. 61571014 and 61601006） Beijing Nature Science Foundation （Grant No. 4172017） General Project of Science and Technology Program of Beijing Education Commission （Grant No.KM201610009004）.
基金Supported by Hebei Province Natural Science Foundation(E2015203407)Young Scholars Research Project of Yanshan University(15LGB011).
文摘Integrating the electric vehicle into grid or microgrid has been receiving more and more attention in recent years.Typically,the electric vehicle(EV)chargers with their power batteries have been developed for vehicle-to-home(V2H)applications,acting as a backup generation to supply emergency power directly to a home.Traditional EV chargers in V2H applications mainly consist of DC/DC and DC/AC stages,which complicate the control algorithm and result in low conversion efficiency.In order to solve this problem,a novel EV charger is proposed for V2H applications.It can boost the battery voltage and output AC voltage with only one-stage power conversion.Also,the DC,1-phase and 3-phase loads can be fed with the proposed single-stage EV charger.The system control strategy is also provided to deal with versatile load variations.Finally,the performance evaluation results verify the effectiveness of the proposed solution.
