Using the monthly mean data from NCEP-NCAR reanalysis, through building tropopause pressure index, we investigated the mechanisms of anomalous variations of tropopause pressure over the Tibetan Plateau during summer i...Using the monthly mean data from NCEP-NCAR reanalysis, through building tropopause pressure index, we investigated the mechanisms of anomalous variations of tropopause pressure over the Tibetan Plateau during summer in Northem Hemisphere. For comparative analysis we selected representative years of 1992 and 1998 to study, and they were respectively the highest and the lowest year oftropopause pressure anomaly over the Tibetan Plateau. The results are summarized as follows： （1） Over the Tibetan Plateau, the variations of tropopause pressure are well correlated respectively with anomalous temperature and geopotential height in both troposphere and stratosphere. Besides, the anomalous tropopause pressure has also close relation with anomalous surface temperature in the Tibetan Plateau. In 1992, the surface temperature was anomalously low, correspondingly, the tropopause pressure over the Tibetan Plateau was anomalously high; but in 1998, the opposite was the case. （2） Over the Tibetan Plateau, the correlation of tropopause pressure and OLR （Outgoing Longwave Radiation） is found to be positive. Furthermore, by further diagnosing the circulation fields between 850 hPa and 200 hPa levels and the whole troposphere vapour field, we found out that the anomalously high tropopause pressure in 1992 corresponded to the anticyclonic divergence of low level wind fields and the cyclonic convergence of high level wind fields, and coupled with divergence of the whole troposphere vapour fields along with the South Asian High weakened at the same time. While in 1998, the case was opposite to that in 1992. These facts indicated that the anomalous convection resulted in the significant difference oftropopause pressure in 1992 and 1998 over the Tibetan Plateau. （3） The vertically integrated heat budget anomalies were responsible for explaining tropopause pressure anomalies in 1992 and 1998 over the Tibetan Plateau.展开更多
We report isoniazid (INH) induced tics in one male patient on hemodialysis at end-stage renal failure. He had pulmonary tuberculosis, accepted isoniazid, rifampin, ethambutol, pyrazinamide and rifampicin. He developed...We report isoniazid (INH) induced tics in one male patient on hemodialysis at end-stage renal failure. He had pulmonary tuberculosis, accepted isoniazid, rifampin, ethambutol, pyrazinamide and rifampicin. He developed tics on both sides of the face. Surprisingly, he was also found the bilateral symmetrical frontal lobe and dentate nucleus hyperintensities on T2-weighted and T2 FLAIR MR imaging. After excluding other causes, INH induced neurological side effect was suspected so the drug was stopped, pyridoxine was added and hemoperfusion was applicated. Tics disappeared after 1 week.展开更多
Purpose: Marchiafava-Bignami Disease (MBD) is a rare condition mainly associated with alcoholism, although a few non-alcoholic cases have been reported. We performed a comparative study of demographic and clinical dif...Purpose: Marchiafava-Bignami Disease (MBD) is a rare condition mainly associated with alcoholism, although a few non-alcoholic cases have been reported. We performed a comparative study of demographic and clinical differences between alcoholic and non-alcoholic and assessed whether any treatment can be recommended. Methods: We reviewed 157 reports containing data on 168 subjects with Alcoholic MBD (AMBD) and 23 subjects with Non-Alcoholic MBD (NAMBD). The following data were extracted: demographic characteristics;delay from the onset of symptoms to admission;MRI features;location of the corpus callosum lesions;the presence of Wernicke’s disease;drug treatment (thiamine, other vitamins and steroids);outcome. Results: The subjects with AMBD were more frequently men (84.5% vs 47.8, P = 0.000);the ones with AMBD were frequently reported as suffering from malnutrition (81.3% vs 50%, P = 0.019), whereas the NAMBD was frequently reported as suffering from diabetes mellitus (30.4% vs 7.1%, P = 0.002). The lesions in the NAMBD are often located in the splenium (47.8%), whereas single splenial lesions are seen only in 18.7% of the AMBD. 43.5% (10/23) of the NAMBD was reported to have recovered completely, whereas only 15.4% (24/156) AMBD showed a complete recovery. Conclusions: It is important to diagnose NAMBD in the early stage with MRI and to treat the symptoms with thiamine and/or corticosteroids according to aetiology. We recommend prompt treatment of MBD with parenteral thiamine in subjects associated with malnutrition, anorexia nervosa and prolonged vomiting, and reduction of food intake. Corticosteroids may aid in recovery by reducing oedema in subjects associated with diabetes mellitus.展开更多
基金supported jointly by the National Basic Research Program of China (2010CB428602)the National Natural Science Foundation of China (41005046,40675025)
文摘Using the monthly mean data from NCEP-NCAR reanalysis, through building tropopause pressure index, we investigated the mechanisms of anomalous variations of tropopause pressure over the Tibetan Plateau during summer in Northem Hemisphere. For comparative analysis we selected representative years of 1992 and 1998 to study, and they were respectively the highest and the lowest year oftropopause pressure anomaly over the Tibetan Plateau. The results are summarized as follows： （1） Over the Tibetan Plateau, the variations of tropopause pressure are well correlated respectively with anomalous temperature and geopotential height in both troposphere and stratosphere. Besides, the anomalous tropopause pressure has also close relation with anomalous surface temperature in the Tibetan Plateau. In 1992, the surface temperature was anomalously low, correspondingly, the tropopause pressure over the Tibetan Plateau was anomalously high; but in 1998, the opposite was the case. （2） Over the Tibetan Plateau, the correlation of tropopause pressure and OLR （Outgoing Longwave Radiation） is found to be positive. Furthermore, by further diagnosing the circulation fields between 850 hPa and 200 hPa levels and the whole troposphere vapour field, we found out that the anomalously high tropopause pressure in 1992 corresponded to the anticyclonic divergence of low level wind fields and the cyclonic convergence of high level wind fields, and coupled with divergence of the whole troposphere vapour fields along with the South Asian High weakened at the same time. While in 1998, the case was opposite to that in 1992. These facts indicated that the anomalous convection resulted in the significant difference oftropopause pressure in 1992 and 1998 over the Tibetan Plateau. （3） The vertically integrated heat budget anomalies were responsible for explaining tropopause pressure anomalies in 1992 and 1998 over the Tibetan Plateau.
文摘We report isoniazid (INH) induced tics in one male patient on hemodialysis at end-stage renal failure. He had pulmonary tuberculosis, accepted isoniazid, rifampin, ethambutol, pyrazinamide and rifampicin. He developed tics on both sides of the face. Surprisingly, he was also found the bilateral symmetrical frontal lobe and dentate nucleus hyperintensities on T2-weighted and T2 FLAIR MR imaging. After excluding other causes, INH induced neurological side effect was suspected so the drug was stopped, pyridoxine was added and hemoperfusion was applicated. Tics disappeared after 1 week.
文摘Purpose: Marchiafava-Bignami Disease (MBD) is a rare condition mainly associated with alcoholism, although a few non-alcoholic cases have been reported. We performed a comparative study of demographic and clinical differences between alcoholic and non-alcoholic and assessed whether any treatment can be recommended. Methods: We reviewed 157 reports containing data on 168 subjects with Alcoholic MBD (AMBD) and 23 subjects with Non-Alcoholic MBD (NAMBD). The following data were extracted: demographic characteristics;delay from the onset of symptoms to admission;MRI features;location of the corpus callosum lesions;the presence of Wernicke’s disease;drug treatment (thiamine, other vitamins and steroids);outcome. Results: The subjects with AMBD were more frequently men (84.5% vs 47.8, P = 0.000);the ones with AMBD were frequently reported as suffering from malnutrition (81.3% vs 50%, P = 0.019), whereas the NAMBD was frequently reported as suffering from diabetes mellitus (30.4% vs 7.1%, P = 0.002). The lesions in the NAMBD are often located in the splenium (47.8%), whereas single splenial lesions are seen only in 18.7% of the AMBD. 43.5% (10/23) of the NAMBD was reported to have recovered completely, whereas only 15.4% (24/156) AMBD showed a complete recovery. Conclusions: It is important to diagnose NAMBD in the early stage with MRI and to treat the symptoms with thiamine and/or corticosteroids according to aetiology. We recommend prompt treatment of MBD with parenteral thiamine in subjects associated with malnutrition, anorexia nervosa and prolonged vomiting, and reduction of food intake. Corticosteroids may aid in recovery by reducing oedema in subjects associated with diabetes mellitus.
