Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Healt...Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020).展开更多
Forkhead box(Fox)transcription factors play important roles in mammalian development and disease.However,their function in mouse somatic cell reprogramming remains unclear.Here,we report that FoxD subfamily and FoxG1 ...Forkhead box(Fox)transcription factors play important roles in mammalian development and disease.However,their function in mouse somatic cell reprogramming remains unclear.Here,we report that FoxD subfamily and FoxG1 accelerate induced pluripotent stem cells(iPSCs)generation from mouse fibroblasts as early as day4 while FoxA and FoxO subfamily impede this process obviously.More importantly,FoxD3,FoxD4 and FoxG1 can replace Oct4 respectively and generate iPSCs with germline transmission together with Sox2 and Klf4.On the contrary,FoxO6 almost totally blocks reprogramming through inhibiting cell proliferation,suppressing the expression of pluripotent genes and hindering the process of mesenchymal to epithelial transition(MET).Thus,our study uncovers unexpected roles of Fox transcription factors in reprogramming and offers new insights into cell fate transition.展开更多
文摘Dear Editor,In 2019,a zoonotic coronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was identified as the causative agent of Coronavirus Disease 2019(COVID-19).As of 8 June 2020,the World Health Organization(WHO)has reported 6,912,751 globally confirmed cases with 400,469 deaths.Although generally causes mild disease,SARS-CoV-2 infection can result in serious outcomes,including acute lung injury(ALI)and acute respiratory distress syndrome(ARDS),the leading cause of mortality in patients with comorbidities.Recent autopsy studies of COVID-19 patients revealed mononuclear infiltration and excessive production of mucus in the infected lung,especially in the damaged small airways and alveoli(Bian and Team,2020;Liu et al.,2020).
基金This research was supported by grants from National Natural Science Foundation of China(numbers 31421004,31530038,31830060,31970681 and 21907095The National Key Research and Development Program of China(2017YFA0504100,2016YFA0101800 and 2018YFE0204800)Science and Technology Planning Project of Guangdong Province(numbers 2017B030314056 and 2019A1515011024)。
文摘Forkhead box(Fox)transcription factors play important roles in mammalian development and disease.However,their function in mouse somatic cell reprogramming remains unclear.Here,we report that FoxD subfamily and FoxG1 accelerate induced pluripotent stem cells(iPSCs)generation from mouse fibroblasts as early as day4 while FoxA and FoxO subfamily impede this process obviously.More importantly,FoxD3,FoxD4 and FoxG1 can replace Oct4 respectively and generate iPSCs with germline transmission together with Sox2 and Klf4.On the contrary,FoxO6 almost totally blocks reprogramming through inhibiting cell proliferation,suppressing the expression of pluripotent genes and hindering the process of mesenchymal to epithelial transition(MET).Thus,our study uncovers unexpected roles of Fox transcription factors in reprogramming and offers new insights into cell fate transition.
