CLGA Net:Cross Layer Gated Attention Network for Image Dehazing

In this paper,we propose an end-to-end cross-layer gated attention network(CLGA-Net)to directly restore fog-free images.Compared with the previous dehazing network,the dehazing model presented in this paper uses the smooth cavity convolution and local residual module as the feature extractor,combined with the channel attention mechanism,to better extract the restored features.A large amount of experimental data proves that the defogging model proposed in this paper is superior to previous defogging technologies in terms of structure similarity index(SSIM),peak signal to noise ratio(PSNR)and subjective visual quality.In order to improve the efficiency of decoding and encoding,we also describe a fusion residualmodule and conduct ablation experiments,which prove that the fusion residual is suitable for the dehazing problem.Therefore,we use fusion residual as a fixed module for encoding and decoding.In addition,we found that the traditional defogging model based on the U-net network may cause some information losses in space.We have achieved effective maintenance of low-level feature information through the cross-layer gating structure that better takes into account global and subtle features.We also present the application of our CLGA-Net in challenging scenarios where the best results in both quantity and quality can be obtained.Experimental results indicate that the present cross-layer gating module can be widely used in the same type of network.

A Near-Infrared Organoplatinum(Ⅱ) Metallacycle Conjugated with Heptamethine Cyanine for Trimodal Cancer Therapy

Discrete Pt(Ⅱ)metallacycles have attracted particular attention for the chemotherapeutic treatment of cancer.However,a single chemotherapy cannot simultaneously balance efficiency and safety because the continuous administration throughout the entire therapy period will lead to inefficient therapy and potentially long-term systemic toxicity.Therefore,the development of a novel organoplatinum(Ⅱ)metallacycle with multimodal treatment capabilities is urgently needed to overcome these issues.Herein,a discrete Pt(II)metallacycle(SCY)bearing the near-infrared(NIR)photosensitizer heptamethine cyanine was fabricated and further encapsulated by amphiphilic 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy(polyethyleneglycol)(DSPEmPEG)to form P@SCY nanoparticles.Heptamethine cyanine,which has excellent photoconversion efficiency,can generate reactive oxygen species(ROS)and heat simultaneously,and the cyanine moiety can target mitochondria in cancer cells due to their quaternary ammonium salt cations,which improve the effect of phototherapy.Due to its excellent phototherapy and chemotherapy properties,P@SCY exhibited remarkable trimodal therapeutic effects[chemo-/photodynamic therapy(PDT)/photothermal therapy(PTT)]against cancer cells(HepG2 cells,MCF-7 cells,and 4T1 cells)in vitro.Furthermore,in vivo results also confirmed thatP@SCY had superior antitumor properties with minimal side effects in the 4T1 tumor model.Thiswork presents a practicable approach to develop a multifunctional organoplatinum(Ⅱ)metallacycle for multimodal tumor therapy.