Objective: The purpose of this study was to examine characteristics associated with neonatal mortality among extremely low- birth- weight infants (≤ 1000 g). Study design: A population- based, case- control study usi...Objective: The purpose of this study was to examine characteristics associated with neonatal mortality among extremely low- birth- weight infants (≤ 1000 g). Study design: A population- based, case- control study using linked Missouri birth and death certificates from 1989 to 1997 was conducted. Cases (n = 835) were defined as extremely low- birth- weight infants that died within 28 days of birth. Controls (n = 907) were randomly selected from extremely low- birth- weight infants that were alive at 1 year and were frequency matched to subjects by birth year and birth weight. Results: Infants born with severe congenital anomalies and at the youngest gestational ages were at greatest risk for neonatal mortality. Other significant risk factors included maternal age (< 18 and >34 years), vaginal delivery, nontertiary hospital care, malpresentation, male gender, and small for gestational age. Black race and preeclampsia were protective against early death. Conclusions: The risk of neonatal mortality among extremely low- birth- weight infants was associated with several maternal, infant, and obstetric factors, some of which may be preventable.展开更多
文摘Objective: The purpose of this study was to examine characteristics associated with neonatal mortality among extremely low- birth- weight infants (≤ 1000 g). Study design: A population- based, case- control study using linked Missouri birth and death certificates from 1989 to 1997 was conducted. Cases (n = 835) were defined as extremely low- birth- weight infants that died within 28 days of birth. Controls (n = 907) were randomly selected from extremely low- birth- weight infants that were alive at 1 year and were frequency matched to subjects by birth year and birth weight. Results: Infants born with severe congenital anomalies and at the youngest gestational ages were at greatest risk for neonatal mortality. Other significant risk factors included maternal age (< 18 and >34 years), vaginal delivery, nontertiary hospital care, malpresentation, male gender, and small for gestational age. Black race and preeclampsia were protective against early death. Conclusions: The risk of neonatal mortality among extremely low- birth- weight infants was associated with several maternal, infant, and obstetric factors, some of which may be preventable.
