Objective:To evaluate the antiniicrobial polenlial of different extracts of the endophytic fungus Phoma sp.and the tentative identification of their active constituents.Methods:The extract and compounds were screened ...Objective:To evaluate the antiniicrobial polenlial of different extracts of the endophytic fungus Phoma sp.and the tentative identification of their active constituents.Methods:The extract and compounds were screened for antimicrobial activity using the Agar Well Diffusion Method.Four compounds were purified using column chromatography and tlieir structures were assigned using～1H and～(13)C NMR spectra,DEPT,2D COSY,HMQC and HMBC experiments.Results:The ethyl acetate fraction of Phoma sp.showed good antifungal,antibacterial,and algicidal properties.One new dihydrofuran derivative,named phomafuranol(1),together with tliree known compounds,phomalacton(2),(3R)-5-hydroxymellein(3)and emodin(4)were isolated from the ethyl acetate fraction of Phoma sp.Preliminary studies indicated that phomalacton(2)displayed strong antibacterial,good antifungal and antialgal activities.Similarly(3R)-5-hydroxymellein(3)and emodin(4)showed good antifungal,antibacterial and algicidal properties.Conclusions:Antimicrobial activities of the ethyl acetate fraction of the endophytic fungus Phoma sp.and isolated compounds clearly demonstrate that Phoma sp.and its active compounds represent a great potential for the food,cosmetic and pharmaceutical industries.展开更多
每支摩托车赛队,每位骑手都在不断地努力提高发动机的性能。对英国Sangha Race and Restoration的老板基兰·桑哈先生个人而言,他明白如果仅仅翻新和更新部件,性能不会有很大提升,于是专门设计出一款高马力的赛车发动机。桑哈先生说...每支摩托车赛队,每位骑手都在不断地努力提高发动机的性能。对英国Sangha Race and Restoration的老板基兰·桑哈先生个人而言,他明白如果仅仅翻新和更新部件,性能不会有很大提升,于是专门设计出一款高马力的赛车发动机。桑哈先生说道:“我的主要工作是专门为赛车客户改装摩托车,业余时间也会享受赛车带来的刺激。部件之间的摩擦是影响发动机和齿轮性能的决定因素,发动机齿轮以最高18000r/min马力为车辆提供动能时,接触面会持续承受应力,导致热量产生造成性能不佳,也可能导致组件故障,无法按照预期水平运行。展开更多
A new metabolite,named seimatoric acid（1）,representing a new oxobutanoic acid derivative has been isolated from Seimatosporium sp., in addition to four known compounds viz.,2-hydroxymethyl-4β,5α,6β-trihydroxycycl...A new metabolite,named seimatoric acid（1）,representing a new oxobutanoic acid derivative has been isolated from Seimatosporium sp., in addition to four known compounds viz.,2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-enone（2）,（-）-phyllostine（3）,（＋）-epiepoxydon（4） and（＋）-epoxydon monoacetate（5）.Similarly one new benzoic acid derivative,named colletonoic acid（6） was isolated from the ethyl acetate fraction of Colletotrichum sp.The structures of the new compounds were elucidated by detailed ^1 H NMR,^13C NMR,COSY,HMQC.HMBC spectroscopic analysis,and HR-E1-MS.Seimatoric acid（1）was also isolated from another taxonomical unidentified fungal strain 4295 in ourgroup.The structures of the known compounds were elucidated by their spectral data comparison to literature data.Preliminary studies showed that colletonoic acid（6） showed good antibacterial,antifungal,and antialgal activities.展开更多
基金supported by the BMBF(Bundesministerium fr Bildung und Forschung,project no.03F0360A)
文摘Objective:To evaluate the antiniicrobial polenlial of different extracts of the endophytic fungus Phoma sp.and the tentative identification of their active constituents.Methods:The extract and compounds were screened for antimicrobial activity using the Agar Well Diffusion Method.Four compounds were purified using column chromatography and tlieir structures were assigned using～1H and～(13)C NMR spectra,DEPT,2D COSY,HMQC and HMBC experiments.Results:The ethyl acetate fraction of Phoma sp.showed good antifungal,antibacterial,and algicidal properties.One new dihydrofuran derivative,named phomafuranol(1),together with tliree known compounds,phomalacton(2),(3R)-5-hydroxymellein(3)and emodin(4)were isolated from the ethyl acetate fraction of Phoma sp.Preliminary studies indicated that phomalacton(2)displayed strong antibacterial,good antifungal and antialgal activities.Similarly(3R)-5-hydroxymellein(3)and emodin(4)showed good antifungal,antibacterial and algicidal properties.Conclusions:Antimicrobial activities of the ethyl acetate fraction of the endophytic fungus Phoma sp.and isolated compounds clearly demonstrate that Phoma sp.and its active compounds represent a great potential for the food,cosmetic and pharmaceutical industries.
文摘每支摩托车赛队,每位骑手都在不断地努力提高发动机的性能。对英国Sangha Race and Restoration的老板基兰·桑哈先生个人而言,他明白如果仅仅翻新和更新部件,性能不会有很大提升,于是专门设计出一款高马力的赛车发动机。桑哈先生说道:“我的主要工作是专门为赛车客户改装摩托车,业余时间也会享受赛车带来的刺激。部件之间的摩擦是影响发动机和齿轮性能的决定因素,发动机齿轮以最高18000r/min马力为车辆提供动能时,接触面会持续承受应力,导致热量产生造成性能不佳,也可能导致组件故障,无法按照预期水平运行。
基金BASF AG and the BMBF(Bundesministerium für Bildung und Forschung,No.03F0360A)
文摘A new metabolite,named seimatoric acid（1）,representing a new oxobutanoic acid derivative has been isolated from Seimatosporium sp., in addition to four known compounds viz.,2-hydroxymethyl-4β,5α,6β-trihydroxycyclohex-2-enone（2）,（-）-phyllostine（3）,（＋）-epiepoxydon（4） and（＋）-epoxydon monoacetate（5）.Similarly one new benzoic acid derivative,named colletonoic acid（6） was isolated from the ethyl acetate fraction of Colletotrichum sp.The structures of the new compounds were elucidated by detailed ^1 H NMR,^13C NMR,COSY,HMQC.HMBC spectroscopic analysis,and HR-E1-MS.Seimatoric acid（1）was also isolated from another taxonomical unidentified fungal strain 4295 in ourgroup.The structures of the known compounds were elucidated by their spectral data comparison to literature data.Preliminary studies showed that colletonoic acid（6） showed good antibacterial,antifungal,and antialgal activities.
