To the Editor,First detected in Wuhan,China,severe acute respiratory syndrome coronavirus 2(SARS CoV 2)virus is creating havoc worldwide and having an unprecedented impact on public health and society,so much so that ...To the Editor,First detected in Wuhan,China,severe acute respiratory syndrome coronavirus 2(SARS CoV 2)virus is creating havoc worldwide and having an unprecedented impact on public health and society,so much so that it was declared a'Public Health Emergency of International Concern’in January 2020 and further as a‘pandemic’in March 2020.So far,it has affected more than 1.7 million people all over the world,causing 110 thousand deaths across 195 countries.展开更多
Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome(EPS).Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or i...Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome(EPS).Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or induced delirium.Anticholinergic induced worsening of psychosis in patients with normal cognition is extremely rare in literature.Here,we arepresenting a case of young female who was prescribed with multiple anticholinergics to reduce EPS,and each time had worsening of psychosis with intact cognition.We then discussed the possible neurobiological explanation with special reference to muscarinic hypothesis of schizophrenia.展开更多
文摘To the Editor,First detected in Wuhan,China,severe acute respiratory syndrome coronavirus 2(SARS CoV 2)virus is creating havoc worldwide and having an unprecedented impact on public health and society,so much so that it was declared a'Public Health Emergency of International Concern’in January 2020 and further as a‘pandemic’in March 2020.So far,it has affected more than 1.7 million people all over the world,causing 110 thousand deaths across 195 countries.
文摘Anticholinergic drugs are commonly used in psychiatry to attenuate antipsychotic induced extrapyramidal syndrome(EPS).Psychosis as a side effect is generally explained under the rubric of anticholinergic toxicity or induced delirium.Anticholinergic induced worsening of psychosis in patients with normal cognition is extremely rare in literature.Here,we arepresenting a case of young female who was prescribed with multiple anticholinergics to reduce EPS,and each time had worsening of psychosis with intact cognition.We then discussed the possible neurobiological explanation with special reference to muscarinic hypothesis of schizophrenia.
