Cell-cell interactions are essential components of coordinated cell function in lung homeostasis.Lung diseases involve altered cell-cell interactions and communication between different cell types,as well as between s...Cell-cell interactions are essential components of coordinated cell function in lung homeostasis.Lung diseases involve altered cell-cell interactions and communication between different cell types,as well as between subsets of cells of the same type.The identification and understanding of intercellular signaling in lung fibrosis offer insights into the molecular mechanisms underlying these interactions and their implications in the development and progression of lung fibrosis.A comprehensive cell atlas of the human lung,established with the facilita-tion of single-cell RNA transcriptomic analysis,has enabled the inference of intercellular communications using ligand-receptor databases.In this review,we provide a comprehensive overview of the modified cell-cell commu-nications in lung fibrosis.We highlight the intricate interactions among the major cell types within the lung and their contributions to fibrogenesis.The insights presented in this review will contribute to a better understand-ing of the molecular mechanisms underlying lung fibrosis and may guide future research efforts in developing targeted therapies for this debilitating disease.展开更多
基金supported by the American Heart Association Career Development Award#19CDA34660211(to T.X.)the Cedars-Sinai Med-ical Center CSRI-Clinical Scholars Award(to T.X.)+4 种基金P01 HL108793(to P.W.N.and B.R.S.)R01 HL151160(to B.R.S.)R35 HL150829(to P.W.N.)National Institute on Aging Grant R01 AG078655(to J.L.and P.W.N.)P01-HL108793(to P.W.N.).
文摘Cell-cell interactions are essential components of coordinated cell function in lung homeostasis.Lung diseases involve altered cell-cell interactions and communication between different cell types,as well as between subsets of cells of the same type.The identification and understanding of intercellular signaling in lung fibrosis offer insights into the molecular mechanisms underlying these interactions and their implications in the development and progression of lung fibrosis.A comprehensive cell atlas of the human lung,established with the facilita-tion of single-cell RNA transcriptomic analysis,has enabled the inference of intercellular communications using ligand-receptor databases.In this review,we provide a comprehensive overview of the modified cell-cell commu-nications in lung fibrosis.We highlight the intricate interactions among the major cell types within the lung and their contributions to fibrogenesis.The insights presented in this review will contribute to a better understand-ing of the molecular mechanisms underlying lung fibrosis and may guide future research efforts in developing targeted therapies for this debilitating disease.
