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miR-200 family expression is downregulated upon neoplastic progression of Barrett's esophagus 被引量:14
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作者 Cameron M Smith David I Watson +4 位作者 Mary P Leong George C Mayne Michael Z Michael bas pl wijnhoven Damian J Hussey 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第8期1036-1044,共9页
AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to ... AIM: To investigate miR-200 family expression in Barrett's epithelium, gastric and duodenal epithelia, and esophageal adenocarcinoma. METHODS: Real-time reverse transcriptase-polymerase chain reaction was used to measure miR-200, ZEB1 and ZEB2 expression. Ingenuity Pathway Analysis of miR-200 targets was used to predict biological outcomes. RESULTS: Barrett's epithelium expressed lower levels of miR-141 and miR-200c than did gastric and duodenal epithelia (P < 0.001). In silico analysis indicated roles for the miR-200 family in molecular pathways that distinguish Barrett's epithelium from gastric and duodenalepithelia, and which control apoptosis and proliferation. All miR-200 members were downregulated in adenocarcinoma (P < 0.02), and miR-200c expression was also downregulated in non-invasive epithelium adjacent to adenocarcinoma (P < 0.02). The expression of all miR-200 members was lower in Barrett's epithelium derived high-grade dysplastic cell lines than in a cell line derived from benign Barrett's epithelium. We observed signif icant inverse correlations between miR-200 family expression and ZEB1 and ZEB2 expression in Barrett's epithelium and esophageal adenocarcinoma (P < 0.05). CONCLUSION: miR-200 expression might contribute to the anti-apoptotic and proliferative phenotype of Barrett's epithelium and regulate key neoplastic processes in this epithelium. 展开更多
关键词 miRNA Barrett’s esophagus Esophageal adenocarcinoma miR-200 Epithelial to mesenchymal transition Apoptosis PROLIFERATION EPITHELIUM
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Four cancer cases after esophageal atresia repair: Time to start screening the upper gastrointestinal tract 被引量:3
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作者 Floor WT Vergouwe Madeleine Gottrand +5 位作者 bas pl wijnhoven Hanneke IJsselstijn Guillaume Piessen Marco J Bruno René MH Wijnen Manon CW Spaander 《World Journal of Gastroenterology》 SCIE CAS 2018年第9期1056-1062,共7页
Esophageal atresia(EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidi... Esophageal atresia(EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia(72%) and gastroesophageal reflux(GER)(67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett's esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett's esophagus and esophageal carcinoma in EA patients, both at a relatively young age. Given these findings, the recent ESPGHAN-NASPGHAN guideline recommends routine endoscopy in adults born with EA. We report a series of four EA patients who developed a carcinoma of the gastrointestinal tract: three esophageal carcinoma and one colorectal carcinoma in a colonic interposition. These cases emphasize the importance of lifelong screening of the upper gastrointestinal tract in EA patients. 展开更多
关键词 Adenocarcinoma ESOPHAGEAL ATRESIA ESOPHAGEAL CANCER SCREENING Barrett’s ESOPHAGUS SQUAMOUS cell carcinoma
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