MicroRNAs （miRNAs） are endogenously encoded small RNA molecules that can bind to cognate messenger RNAs, thereby impairing protein expression, miRNAs are transcribed from the genome as long precursor molecules that ...MicroRNAs （miRNAs） are endogenously encoded small RNA molecules that can bind to cognate messenger RNAs, thereby impairing protein expression, miRNAs are transcribed from the genome as long precursor molecules that are processed via multiple steps into their mature form of-22 nt. Embedded in an RNA Induced Silencing Complex （RISC）, miRNAs can bind to target RNAs by base complementarity, after which the target is degraded and/or translation is terminated, miRNA-based regulation has been shown to function in a wide variety of processes, such as development, stress response, and finetuning of physiological pathways.展开更多
文摘MicroRNAs （miRNAs） are endogenously encoded small RNA molecules that can bind to cognate messenger RNAs, thereby impairing protein expression, miRNAs are transcribed from the genome as long precursor molecules that are processed via multiple steps into their mature form of-22 nt. Embedded in an RNA Induced Silencing Complex （RISC）, miRNAs can bind to target RNAs by base complementarity, after which the target is degraded and/or translation is terminated, miRNA-based regulation has been shown to function in a wide variety of processes, such as development, stress response, and finetuning of physiological pathways.
