Primary spontaneous pneumothorax （PSP） is a common clinical problem occurring in apparently healthy subjects. However emphysema like changes （ELC） in patients with （PSP） has been demonstrated, which is associate...Primary spontaneous pneumothorax （PSP） is a common clinical problem occurring in apparently healthy subjects. However emphysema like changes （ELC） in patients with （PSP） has been demonstrated, which is associated with the degradation of extraceilular matrix （ECM）. MMP-9 has been proposed to play a role in the development of emphysema and is involved in the digestion of （ECM）. Among several polymorphic changes reported in MMP-9 regulatory region, the C-1562T polymorphism increases its promoter activity Aim of the work： To test the hypothesis that the MMP-9 C-1562T polymorphism has a role in the occurrence of PSP. Subjects and Methods： MMP-9 （C-1562T） genotypes of 104 PSP patients and 97 healthy subjects （control） were determined by the polymerase chain reaction, followed by a restriction fragment length polymorphism analysis. Results： This study showed that the genotype frequency for MMP-9 1562 C 〉 T differed significantly between healthy individuals and PSP patients, with higher T allele in MMP-9 promoter in PSP patients, and the C/T ＋ T/T genotypes significantly modified the risk of developing PSP, and were associated with increased risk for PSP. Conclusion： MMP-9-1562C/T genotype may be a potentially indicative factor for susceptibility to PSP, that is, genotypes with the T allele significantly increase the risk of development of PSP.展开更多
文摘Primary spontaneous pneumothorax （PSP） is a common clinical problem occurring in apparently healthy subjects. However emphysema like changes （ELC） in patients with （PSP） has been demonstrated, which is associated with the degradation of extraceilular matrix （ECM）. MMP-9 has been proposed to play a role in the development of emphysema and is involved in the digestion of （ECM）. Among several polymorphic changes reported in MMP-9 regulatory region, the C-1562T polymorphism increases its promoter activity Aim of the work： To test the hypothesis that the MMP-9 C-1562T polymorphism has a role in the occurrence of PSP. Subjects and Methods： MMP-9 （C-1562T） genotypes of 104 PSP patients and 97 healthy subjects （control） were determined by the polymerase chain reaction, followed by a restriction fragment length polymorphism analysis. Results： This study showed that the genotype frequency for MMP-9 1562 C 〉 T differed significantly between healthy individuals and PSP patients, with higher T allele in MMP-9 promoter in PSP patients, and the C/T ＋ T/T genotypes significantly modified the risk of developing PSP, and were associated with increased risk for PSP. Conclusion： MMP-9-1562C/T genotype may be a potentially indicative factor for susceptibility to PSP, that is, genotypes with the T allele significantly increase the risk of development of PSP.
