BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme...BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme metabolism.Compared to remimazolam,remimazolam benzenesulfonate has a faster effect,is more quickly metabolized,produces inactive metabolites and has weak drug interactions.Thus,remimazolam benzenesulfonate has good effectiveness and safety for diagnostic and operational sedation.AIM To investigate the clinical value of remimazolam benzenesulfonate in cardiac surgery patients under general anesthesia.METHODS A total of 80 patients who underwent surgery in the Department of Cardiothoracic Surgery from August 2020 to April 2021 were included in the study.Using a random number table,patients were divided into two anesthesia induction groups of 40 patients each:remimazolam(0.3 mg/kg remimazolam benzenesulfonate)and propofol(1.5 mg/kg propofol).Hemodynamic parameters,inflammatory stress response indices,respiratory function indices,perioperative indices and adverse reactions in the two groups were monitored over time for comparison.RESULTS At pre-anesthesia induction,the remimazolam and propofol groups did not differ regarding heart rate,mean arterial pressure,cardiac index or volume per wave index.After endotracheal intubation and when the sternum was cut off,mean arterial pressure and volume per wave index were significantly higher in the remimazolam group than in the propofol group(P<0.05).After endotracheal intubation,the oxygenation index and the respiratory index did not differ between the groups.After endotracheal intubation and when the sternum was cut off,the oxygenation index values were significantly higher in the remimazolam group than in the propofol group(P<0.05).Serum interleukin-6 and tumor necrosis factor-αlevels 12 h after surgery were significantly higher than before surgery in both groups(P<0.05).The observation indices were re-examined 2 h after surgery,and the epinephrine,cortisol and blood glucose levels were significantly higher in the remimazolam group than in the propofol group(P<0.05).The recovery and extubation times were significantly lower in the remimazolam group than in the propofol group(P<0.05);there were significantly fewer adverse reactions in the remimazolam group(10.00%)than in the propofol group(30.00%;P<0.05).CONCLUSION Compared with propofol,remimazolam benzenesulfonate benefited cardiac surgery patients under general anesthesia by reducing hemodynamic fluctuations.Remimazolam benzenesulfonate influenced the surgical stress response and respiratory function,thereby reducing anesthesia-related adverse reactions.展开更多
B.L.U.E.建筑设计事务所B.L.U.E.建筑设计事务所成立于2014年,由日本建筑师青山周平与藤井洋子共同创建于北京,是一所面向建筑与室内设计方向,充满年轻活力的国际化建筑事务所。B.L.U.E.是Beijing Laboratory for Urban Environment的略...B.L.U.E.建筑设计事务所B.L.U.E.建筑设计事务所成立于2014年,由日本建筑师青山周平与藤井洋子共同创建于北京,是一所面向建筑与室内设计方向,充满年轻活力的国际化建筑事务所。B.L.U.E.是Beijing Laboratory for Urban Environment的略称,同时也是事务所的核心设计哲学。以厚重历史与先锐思潮激烈碰撞的北京为中心,通过建筑、室内、产品、艺术等设计实践,实现对城市物理、社会、文化环境等方面的研究,寻求一个真正连接城市环境的设计平台。展开更多
China North Industries Corp. (Norinco) under the China Ordnance Industry Corp. was founded in February 1980. A huge mechano-electrical product exporter, it stands in the forefront of the 500 top foreign trade enterpri...China North Industries Corp. (Norinco) under the China Ordnance Industry Corp. was founded in February 1980. A huge mechano-electrical product exporter, it stands in the forefront of the 500 top foreign trade enterprises in the country. To prepareits products for the market, Norinco has readjusted its industrial and institutional structures in line with the modern enterprise system. It has built itself into a technology-industry-展开更多
B.L.U.E.建筑设计事务所成立于2014年,由日本建筑师青山周平与藤井洋子共同创建于北京,是一所面向建筑以及建筑室内设计方向,充满年轻活力的国际化建筑事务所。B.L.U.E.是Beijing Laboratory for Urban Environment的略称,同时也是事务...B.L.U.E.建筑设计事务所成立于2014年,由日本建筑师青山周平与藤井洋子共同创建于北京,是一所面向建筑以及建筑室内设计方向,充满年轻活力的国际化建筑事务所。B.L.U.E.是Beijing Laboratory for Urban Environment的略称,同时也是事务所的核心设计哲学。以厚重历史与先锐思潮激烈碰撞的北京为中心,通过建筑、室内、产品、艺术等设计实践,实现对城市物理、社会、文化环境等方面的研究,寻求一个真正连接城市环境的设计平台。展开更多
基金The First Affiliated Hospital of Nanchang University Ethics Committee.
文摘BACKGROUND Sedation with propofol injections is associated with a risk of addiction,but remimazolam benzenesulfonate is a comparable anesthetic with a short elimination half-life and independence from cell P450 enzyme metabolism.Compared to remimazolam,remimazolam benzenesulfonate has a faster effect,is more quickly metabolized,produces inactive metabolites and has weak drug interactions.Thus,remimazolam benzenesulfonate has good effectiveness and safety for diagnostic and operational sedation.AIM To investigate the clinical value of remimazolam benzenesulfonate in cardiac surgery patients under general anesthesia.METHODS A total of 80 patients who underwent surgery in the Department of Cardiothoracic Surgery from August 2020 to April 2021 were included in the study.Using a random number table,patients were divided into two anesthesia induction groups of 40 patients each:remimazolam(0.3 mg/kg remimazolam benzenesulfonate)and propofol(1.5 mg/kg propofol).Hemodynamic parameters,inflammatory stress response indices,respiratory function indices,perioperative indices and adverse reactions in the two groups were monitored over time for comparison.RESULTS At pre-anesthesia induction,the remimazolam and propofol groups did not differ regarding heart rate,mean arterial pressure,cardiac index or volume per wave index.After endotracheal intubation and when the sternum was cut off,mean arterial pressure and volume per wave index were significantly higher in the remimazolam group than in the propofol group(P<0.05).After endotracheal intubation,the oxygenation index and the respiratory index did not differ between the groups.After endotracheal intubation and when the sternum was cut off,the oxygenation index values were significantly higher in the remimazolam group than in the propofol group(P<0.05).Serum interleukin-6 and tumor necrosis factor-αlevels 12 h after surgery were significantly higher than before surgery in both groups(P<0.05).The observation indices were re-examined 2 h after surgery,and the epinephrine,cortisol and blood glucose levels were significantly higher in the remimazolam group than in the propofol group(P<0.05).The recovery and extubation times were significantly lower in the remimazolam group than in the propofol group(P<0.05);there were significantly fewer adverse reactions in the remimazolam group(10.00%)than in the propofol group(30.00%;P<0.05).CONCLUSION Compared with propofol,remimazolam benzenesulfonate benefited cardiac surgery patients under general anesthesia by reducing hemodynamic fluctuations.Remimazolam benzenesulfonate influenced the surgical stress response and respiratory function,thereby reducing anesthesia-related adverse reactions.
文摘B.L.U.E.建筑设计事务所B.L.U.E.建筑设计事务所成立于2014年,由日本建筑师青山周平与藤井洋子共同创建于北京,是一所面向建筑与室内设计方向,充满年轻活力的国际化建筑事务所。B.L.U.E.是Beijing Laboratory for Urban Environment的略称,同时也是事务所的核心设计哲学。以厚重历史与先锐思潮激烈碰撞的北京为中心,通过建筑、室内、产品、艺术等设计实践,实现对城市物理、社会、文化环境等方面的研究,寻求一个真正连接城市环境的设计平台。
文摘China North Industries Corp. (Norinco) under the China Ordnance Industry Corp. was founded in February 1980. A huge mechano-electrical product exporter, it stands in the forefront of the 500 top foreign trade enterprises in the country. To prepareits products for the market, Norinco has readjusted its industrial and institutional structures in line with the modern enterprise system. It has built itself into a technology-industry-
文摘B.L.U.E.建筑设计事务所成立于2014年,由日本建筑师青山周平与藤井洋子共同创建于北京,是一所面向建筑以及建筑室内设计方向,充满年轻活力的国际化建筑事务所。B.L.U.E.是Beijing Laboratory for Urban Environment的略称,同时也是事务所的核心设计哲学。以厚重历史与先锐思潮激烈碰撞的北京为中心,通过建筑、室内、产品、艺术等设计实践,实现对城市物理、社会、文化环境等方面的研究,寻求一个真正连接城市环境的设计平台。
