期刊文献+
共找到4篇文章
< 1 >
每页显示 20 50 100
Continuous renal replacement therapy with oXiris®in patients with hematologically malignant septic shock:A retrospective study
1
作者 Juan Wang Shu-Run Wei +10 位作者 Tong Ding Li-Ping Zhang Zhi-Hua Weng Ming Cheng yang Zhou Meng Zhang Fang-Jun Liu bei-bei yan Dan-Feng Wang Ming-Wen Sun Wei-Xin Cheng 《World Journal of Clinical Cases》 SCIE 2023年第26期6073-6082,共10页
BACKGROUND The mortality rate from septic shock in patients with hematological malignancies(HMs)remains significantly higher than that in patients without HMs.A longer resuscitation time would definitely be harmful be... BACKGROUND The mortality rate from septic shock in patients with hematological malignancies(HMs)remains significantly higher than that in patients without HMs.A longer resuscitation time would definitely be harmful because of the irreversibly immunocompromised status of the patients.Shortening the resuscitation time through continuous renal replacement therapy(CRRT)with oXiris^(■)would be an attractive strategy in managing such patients.AIM To explore the effects of CRRT and oXiris^(■)in shortening the resuscitation time and modifying the host response by reducing inflammation mediator levels.METHODS Forty-five patients with HM were diagnosed with septic shock and underwent CRRT between 2018 and 2022.Patients were divided into two groups based on the hemofilter used for CRRT(oXiris^(■)group,n=26;M150 group,n=19).We compared the number of days of negative and total fluid balance after 7 d of CRRT between the groups.The heart rate,norepinephrine dose,Sequential Organ Failure Assessment(SOFA)score,and blood lactic acid levels at different time points in the two groups were also compared.Blood levels of inflammatory mediators in the 26 patients in the oXiris^(■)group were measured to further infer the possible mechanism.RESULTS The average total fluid balance after 7 d of CRRT in the oXiris^(■)group was significantly lower than that of patients in the M150 hemofilter group.The SOFA scores of patients after CRRT with oXiris^(■)therapy were significantly lower than those before treatment on day 1(d1),d3 and d7 after CRRT;these parameters were also significantly lower than those of the control group on d7.The lac level after oXiris^(■)therapy was significantly lower than that before treatment on d3 and d7 after CRRT.There were no significant differences in the above parameters between the two groups at the other time points.In the oXiris^(■)group,procalcitonin levels decreased on d7,whereas interleukin-6 and tumor necrosis factor levels decreased significantly on d3 and d7 after treatment.CONCLUSION CRRT with oXiris^(■)hemofilter may improve hemodynamics by reducing inflammatory mediators and playing a role in shortening the resuscitation period and decreasing total fluid balance in the resuscitation phases. 展开更多
关键词 Hematological malignancy Septic shock oXiris®hemofilter Blood purification Fluid balance
下载PDF
Calcium carbonate-doxorubicin @silica-indocyanine green nanospheres with photo-triggered drug delivery enhance cell killing in drug-resistant breast cancer cells
2
作者 Wei Wang yang Zhao +3 位作者 bei-bei yan Liang Dong yang Lu Shu-Hong Yu 《Nano Research》 SCIE EI CAS CSCD 2018年第6期3385-3395,共11页
Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with high uniformity and monodispersity were designed and synthesized, in order to provide a photo-triggered strategy for drug-resistant cancer therap... Calcium carbonate-doxorubicin@silica-indocyanine green nanospheres with high uniformity and monodispersity were designed and synthesized, in order to provide a photo-triggered strategy for drug-resistant cancer therapy. Under near-infrared laser irradiation, the nanospheres transformed laser power into local heat and reactive oxygen species via the connected indocyanine green molecule, thus exhibiting photothermal and photodynamic effects. Moreover, the photo-triggered drug release based on calcium-assisted silica degradation was observed, endowing the nanospheres with chemotherapeutic properties. Finally, combined therapeutic effects against drug-resistant human breast cancer cells were successfully obtained. These photo-triggered materials based on calcium carbonate could provide a promising platform for enhanced multimodal cancer therapies. 展开更多
关键词 calcium carbonate-based structures photothermal therapy photodynamic therapy combined therapeutic effects
原文传递
生物质衍生醇类水相重整制氢研究进展(英文) 被引量:1
3
作者 Guan-yi CHEN Wan-qing LI +1 位作者 Hong CHEN bei-bei yan 《Journal of Zhejiang University-Science A(Applied Physics & Engineering)》 SCIE EI CAS CSCD 2015年第6期491-506,共16页
氢气作为一种清洁、高效的可持续能源,近年来得到了广泛关注。水相重整技术以生物质衍生醇类制备氢气,具有来源广泛、反应条件温和、运行成本较低等优点,相较于其他制氢方法更有优势。本文详细阐述生物质衍生醇类水相重整制氢的研究进展... 氢气作为一种清洁、高效的可持续能源,近年来得到了广泛关注。水相重整技术以生物质衍生醇类制备氢气,具有来源广泛、反应条件温和、运行成本较低等优点,相较于其他制氢方法更有优势。本文详细阐述生物质衍生醇类水相重整制氢的研究进展,同时讨论不同催化剂的反应机理。Pt系催化剂表现出较高的氢气选择性,但是醇类转化率较低。Ni系催化剂反应活性和转化率均较高,但仍存在氢气选择性和氢气产率较低等问题。 展开更多
关键词 生物质 醇类 制氢 水相重整制氢 反应机理 催化剂
原文传递
Activating proper inflammation for wound-healing acceleration via mesoporous silica nanoparticle tissue adhesive
4
作者 Zhao Pan Kai-Run Zhang +9 位作者 Huai-Ling Gao Yong Zhou bei-bei yan Chi yang Zhi-Yuan Zhang Liang Dong Si-Ming Chen Rui Xu Duo-Hong Zou Shu-Hong Yu 《Nano Research》 SCIE EI CAS CSCD 2020年第2期373-379,共7页
Efficient initiation and resolution of inflammation are crucial for wound repair.However,with using tissue adhesives for wound repair,patients occasionally suffered from delayed healing process because slow eliminatio... Efficient initiation and resolution of inflammation are crucial for wound repair.However,with using tissue adhesives for wound repair,patients occasionally suffered from delayed healing process because slow elimination of those exogenous adhesives generally leads to chronic inflammation.As the demand for minimal invasive therapy continues to rise,desire for adhesive materials that can effectively reconnect surgical gaps and promote wound regeneration becomes increasingly urgent.Herein,by exploiting the inherent porous structure and performance of adhesion to tissue of mesoporous silica nanoparticles(MSNs),we demonstrate a tissue adhesive that can elicit acute inflammatory response and get eliminated after tissue reformation.With formation of nanocomposites in wound gaps,the injured tissues can get reconnected conveniently.The resultant accelerated healing process verifty that the strategy of exploiting unique properties of nanomaterials can effectively promote inflammation resolution and wound repair.This design strategy will inspire more innovative tissue adhesives for clinical applications. 展开更多
关键词 mesoporous nanoparticle tissue adhesive wound repair INFLAMMATION accelerated healing
原文传递
上一页 1 下一页 到第
使用帮助 返回顶部