Background:The successful aging of middle-aged and older adults in developing countries is still in the exploratory stage.This paper aims to understand the current situation of successful aging of middle-aged and olde...Background:The successful aging of middle-aged and older adults in developing countries is still in the exploratory stage.This paper aims to understand the current situation of successful aging of middle-aged and older adults in developing countries and systematically evaluate the factors influencing successful aging of middle-aged and older adults in developing countries.Methods:We searched databases including PubMed,Embase,the Cochrane Library,Web of Science,Chinese National Knowledge Infrastructure,CBM,WanFang Data Knowledge Service Platform and VIP from inception to April 30,2021.RevMan 5.3 software was used for meta-analysis.Results:Fourteen studies were included and 17 related risk factors were analyzed.The statistically significant influence factors were gender(odds ratio(OR)=1.37,95%confidenceinterval(CI):1.09~1.71),age>75 years(OR=0.46,95%CI:0.31~0.68),education level(OR=3.24,95%CI:1.84~5.70),Cohabiting with a partner(OR=0.17,95%CI:0.11~0.24),domicile(OR=2.60,95%CI:1.07~6.29),self-rated health(OR=3.15,95%CI:2.33~4.24),income(OR=1.72,95%CI:1.04~2.86),smoking(OR=1.33,95%CI:1.16~1.53),alcohol intake(OR=1.61,95%CI:1.09~2.37),body pain(OR=0.28,95%CI:0.09~0.84),hearing impaired(OR=0.28,95%CI:0.13~0.59),physical exercise(OR=1.46,95%CI:1.24~1.73),eating pattern(OR=1.47,95%CI:1.19~1.80),sleep disorder(OR=0.49,95%CI:0.27~0.89).Sensitivity analysis results show that the results of meta-analysis are stable.Conclusion:Current evidence shows that men living in cities and towns,living with their spouse,good financial status,high educational level,self-rated health,low alcohol consumption,physical exercise and regular diet are beneficial to the successful aging of middle-aged and older adults factor.For ages over 75 years old,five factors,such as long-term smoking,physical pain,hearing impairment and sleep disturbance are the unfavorable factors that hinder successful aging.展开更多
Chiroptical properties including electronic circular dichroism(ECD) and optical rotatory dispersion(ORD) of artemisinin and artemether have been fully studied using quantum-chemical calculation based on time-dependent...Chiroptical properties including electronic circular dichroism(ECD) and optical rotatory dispersion(ORD) of artemisinin and artemether have been fully studied using quantum-chemical calculation based on time-dependent density functional theory.Both theoretical ECD and ORD of these two compounds were in good match with the experimental data.ECD spectrum of artemether could be totally attributed to the peroxide group,and that of artemisinin was an overlay of contribution from δ-lactone and peroxide moieties,which leading to a positive maximum at 260 nm.Our results showed that peroxide group could produce a broad ECD band in the far-UV region originated from electron transitions of HOMO →LUMO,HOMO-1 →LUMO and HOMO-2 →LUMO in the case of artemether.This work provided a theoretical interpretation of the ECD behavior of peroxide bond.展开更多
文摘Background:The successful aging of middle-aged and older adults in developing countries is still in the exploratory stage.This paper aims to understand the current situation of successful aging of middle-aged and older adults in developing countries and systematically evaluate the factors influencing successful aging of middle-aged and older adults in developing countries.Methods:We searched databases including PubMed,Embase,the Cochrane Library,Web of Science,Chinese National Knowledge Infrastructure,CBM,WanFang Data Knowledge Service Platform and VIP from inception to April 30,2021.RevMan 5.3 software was used for meta-analysis.Results:Fourteen studies were included and 17 related risk factors were analyzed.The statistically significant influence factors were gender(odds ratio(OR)=1.37,95%confidenceinterval(CI):1.09~1.71),age>75 years(OR=0.46,95%CI:0.31~0.68),education level(OR=3.24,95%CI:1.84~5.70),Cohabiting with a partner(OR=0.17,95%CI:0.11~0.24),domicile(OR=2.60,95%CI:1.07~6.29),self-rated health(OR=3.15,95%CI:2.33~4.24),income(OR=1.72,95%CI:1.04~2.86),smoking(OR=1.33,95%CI:1.16~1.53),alcohol intake(OR=1.61,95%CI:1.09~2.37),body pain(OR=0.28,95%CI:0.09~0.84),hearing impaired(OR=0.28,95%CI:0.13~0.59),physical exercise(OR=1.46,95%CI:1.24~1.73),eating pattern(OR=1.47,95%CI:1.19~1.80),sleep disorder(OR=0.49,95%CI:0.27~0.89).Sensitivity analysis results show that the results of meta-analysis are stable.Conclusion:Current evidence shows that men living in cities and towns,living with their spouse,good financial status,high educational level,self-rated health,low alcohol consumption,physical exercise and regular diet are beneficial to the successful aging of middle-aged and older adults factor.For ages over 75 years old,five factors,such as long-term smoking,physical pain,hearing impairment and sleep disturbance are the unfavorable factors that hinder successful aging.
基金supported by the Fundamental Research Funds for the Central Institutes of China(No.2012ZD03)
文摘Chiroptical properties including electronic circular dichroism(ECD) and optical rotatory dispersion(ORD) of artemisinin and artemether have been fully studied using quantum-chemical calculation based on time-dependent density functional theory.Both theoretical ECD and ORD of these two compounds were in good match with the experimental data.ECD spectrum of artemether could be totally attributed to the peroxide group,and that of artemisinin was an overlay of contribution from δ-lactone and peroxide moieties,which leading to a positive maximum at 260 nm.Our results showed that peroxide group could produce a broad ECD band in the far-UV region originated from electron transitions of HOMO →LUMO,HOMO-1 →LUMO and HOMO-2 →LUMO in the case of artemether.This work provided a theoretical interpretation of the ECD behavior of peroxide bond.
