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Hepatoprotective and antioxidant activity of ethanolic extract of Artabotrys odoratissimus stem on rifampicin-induced hepatotoxicity in rats
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作者 Hindustan Abdul Ahad Chinthaginjala Haranath +1 位作者 Bhupalam Pradeepkumar beludari mohammed ishaq 《Drug Combination Therapy》 2021年第2期9-17,共9页
The area of the existing examination was to explore the cancer prevention agent and hepatoprotective action of ethanolic stem concentrate of Artabotrys odoratissimus in rifampicin caused hepatotoxicity in albino wiste... The area of the existing examination was to explore the cancer prevention agent and hepatoprotective action of ethanolic stem concentrate of Artabotrys odoratissimus in rifampicin caused hepatotoxicity in albino wister rodents.The material was dehydrated in gloom;they were powdered,extricated with ethanol later primer phytochemical tests were finished.The hepatoprotective action of the ethanol extract was evaluated in albino wister rodents.Rifampicin(100 mg/kg)has upgraded the degrees of different biochemical markers of the liver like serum glutamic oxaloacetic transaminase,serum glutamate pyruvate transaminase,aspartate alkaline phosphatase and bilirubin.The different biochemical and histopathological examinations have done were aspartate alkaline phosphatase,aminotransferase,alanine transaminase,bilirubin,cell reinforcement movement by 1,1-diphenyl 2-picryl hydrazyl,nitro blue tetrazolium,hydrogen peroxide,lipid perioxidation,hydroxyl revolutionary and nitric oxide techniques.Treatment of ethanolic concentrate of the stem of Artabotrys odoratissimus(100 mg/kg,200 mg/kg and 400 mg/kg)has brought back the changed degrees of biochemical markers to the close ordinary levels in the portion subordinate way.Our discoveries proposed that Artabotrys odoratissimus ethanol stem extricate had an intense cell reinforcement and hepatoprotective action. 展开更多
关键词 Artabotrys odoratissimus RIFAMPICIN Liver protection HISTOPATHOLOGY
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