Synthesis of novel <sup>225</sup>Ac-Sn particles was described for the first time. Detailed experimental and stability studies were successfully exhibited. Treatment of excess amount of SnCl<sub>2<...Synthesis of novel <sup>225</sup>Ac-Sn particles was described for the first time. Detailed experimental and stability studies were successfully exhibited. Treatment of excess amount of SnCl<sub>2</sub> with 0.2 mCi <sup>225</sup>Ac furnished highly stable <sup>225</sup>Ac tin colloid with 90% of radiochemical yield (RCY) at optimized reaction condition. R-TLC analyses indicated 95% of radiochemical purity (RCP). Stability studies showed that colloidal structure also retained free daughter radionuclides formed by the <sup>225</sup>Ac decay chain. <sup>225</sup>Ac tin colloids could be ideal nanocarriers for localized cell killing due to high linear energy transfer and prevention of free radioisotope daughters.展开更多
文摘Synthesis of novel <sup>225</sup>Ac-Sn particles was described for the first time. Detailed experimental and stability studies were successfully exhibited. Treatment of excess amount of SnCl<sub>2</sub> with 0.2 mCi <sup>225</sup>Ac furnished highly stable <sup>225</sup>Ac tin colloid with 90% of radiochemical yield (RCY) at optimized reaction condition. R-TLC analyses indicated 95% of radiochemical purity (RCP). Stability studies showed that colloidal structure also retained free daughter radionuclides formed by the <sup>225</sup>Ac decay chain. <sup>225</sup>Ac tin colloids could be ideal nanocarriers for localized cell killing due to high linear energy transfer and prevention of free radioisotope daughters.
