Dear Editor,Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the oxidative pentose phosphate pathway(oxPPP)that can generate cytosolic NADPH(Fig.1a)for biosynthesis and oxidative defence.Here,we r...Dear Editor,Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the oxidative pentose phosphate pathway(oxPPP)that can generate cytosolic NADPH(Fig.1a)for biosynthesis and oxidative defence.Here,we reveal a previously unidentified function of G6PD.It,even the natural G6PD deficiency-associated mutant without the activity to maintain the normal oxPPP,can antagonize the stresses by supporting the reductive glutamine metabolism and AMPK activation,independently of the NADPH generation by the oxPPP.展开更多
基金supporled in part by grants from the National Nature Science Foundation of China(81972567 and 81672762 to B.L.,81830087,U1602221 and 31771516 to C.C.81802671 and 81872414 to DJ.)Grant CIT&TCD20190333 from the Support Projectof High-level Teachers in Beijing Municipal Universities in the Period of 13th Five-year Plan,Tianjin Natural Science Foundation(No.18JCONJC79600)+1 种基金Project oflnnovative Research Team of Yunnan Province(2019HCO05)Yunnan Funda-mentall Pesearch Projects(12019FB112 and 202001A070018 to DJ).
文摘Dear Editor,Glucose-6-phosphate dehydrogenase(G6PD)is the rate-limiting enzyme in the oxidative pentose phosphate pathway(oxPPP)that can generate cytosolic NADPH(Fig.1a)for biosynthesis and oxidative defence.Here,we reveal a previously unidentified function of G6PD.It,even the natural G6PD deficiency-associated mutant without the activity to maintain the normal oxPPP,can antagonize the stresses by supporting the reductive glutamine metabolism and AMPK activation,independently of the NADPH generation by the oxPPP.
