Epidermal growth factor receptor(EGFR) is a transmembrane receptor with tyrosine kinase activity,mediating actions of various growth factors including EGF, transforming growth factor-α, and neuregulins.Protein bindin...Epidermal growth factor receptor(EGFR) is a transmembrane receptor with tyrosine kinase activity,mediating actions of various growth factors including EGF, transforming growth factor-α, and neuregulins.Protein binding to ligand induces receptor modification,tyrosine autophosphorylation leading to cell signaling resulting in cellular proliferation. This receptor playsdiverse roles in maintaining homeostasis and recent molecular advances identify that EGFR mutations are linked to several carcinomas. EGFR plays important roles in the development and maintenance of various oral structures, tooth development, eruption and morphogenesis. EGFR expression has also been studied in diverse oral pathologies like squamous cell carcinomas, potentially malignant lesions, lichen planus, salivary gland tumors and odontogenic cysts and tumours. The present review delves into the various general features of EGFR with an insight into its physiological and pathological role in the oral cavity. The clinical implications and upcoming role of EGFR inhibitors in the nonsurgical treatment of oral lesions has also been discussed.展开更多
文摘Epidermal growth factor receptor(EGFR) is a transmembrane receptor with tyrosine kinase activity,mediating actions of various growth factors including EGF, transforming growth factor-α, and neuregulins.Protein binding to ligand induces receptor modification,tyrosine autophosphorylation leading to cell signaling resulting in cellular proliferation. This receptor playsdiverse roles in maintaining homeostasis and recent molecular advances identify that EGFR mutations are linked to several carcinomas. EGFR plays important roles in the development and maintenance of various oral structures, tooth development, eruption and morphogenesis. EGFR expression has also been studied in diverse oral pathologies like squamous cell carcinomas, potentially malignant lesions, lichen planus, salivary gland tumors and odontogenic cysts and tumours. The present review delves into the various general features of EGFR with an insight into its physiological and pathological role in the oral cavity. The clinical implications and upcoming role of EGFR inhibitors in the nonsurgical treatment of oral lesions has also been discussed.
