Dear Editor,Cancer-associated fibroblasts(CAFs)are highly ver-satile and plastic cells in the tumor microenvironment.They have been identified as actively involved in can-cer progression and metastasis through their v...Dear Editor,Cancer-associated fibroblasts(CAFs)are highly ver-satile and plastic cells in the tumor microenvironment.They have been identified as actively involved in can-cer progression and metastasis through their various roles in remodeling the extracellular matrix,suppressing the immune response and reprogramming tumor metabolism[1].However,many challenges exist in revealing the func-tional phenotypes and mechanisms of CAFs in different cancers due to limited understanding of CAF hetero-geneity[2].展开更多
基金supported by grants from the National Natural Science Foundation of China(No.82173253)the Sichuan Province Science and Technology Support Program(No.2022YFH0003 and No.2023NSFSC1900)the Postdoctoral Research Foundation of China(No.2022M712260).
文摘Dear Editor,Cancer-associated fibroblasts(CAFs)are highly ver-satile and plastic cells in the tumor microenvironment.They have been identified as actively involved in can-cer progression and metastasis through their various roles in remodeling the extracellular matrix,suppressing the immune response and reprogramming tumor metabolism[1].However,many challenges exist in revealing the func-tional phenotypes and mechanisms of CAFs in different cancers due to limited understanding of CAF hetero-geneity[2].
