Background: There is wide variation in the objective visual variables used to measure atopic eczema severity in clinical trials, making comparison and interpretation of results difficult. Objective: To provide a ratio...Background: There is wide variation in the objective visual variables used to measure atopic eczema severity in clinical trials, making comparison and interpretation of results difficult. Objective: To provide a rationale for simplifying and standardizing objective atopic eczema scoring by investigating which visual variables provide the best measure of disease severity from the patient’ s perspective. Setting: The dermatology outpatient department at the Queen’ s Medical Centre, University Hospital in Nottingham, and 5 local general practices. Patients: One hundred eighty individuals with atopic eczema. Interventions: Clinical examination with scoring of 7 clinical signs and disease extent, followed by regression analyses of visual variable scores against a patient- rated measure of current disease severity. Results: Objective measurements account for only a quarter of the variation in patient- rated disease severity. Three clinical signs were independent predictors of patient- rated disease severity: excoriations, erythema, and edema/papulation. Disease extent measurements do not reflect patient- rated disease severity in a linear manner, with mean severity scores increasing little above 30% body surface area involvement. Conclusions: From the patient’ s perspective, the measurement of 3 clinical signs- excoriations, erythema, and edema/papulation- provides as much information about current atopic eczema severity as more complex scoring systems that measure multiple clinical signs and disease extent. The simplicity of the Three Item Severity score, a previously published atopic eczema score based on measurement of these 3 clinical signs, makes it a suitable tool for research studies or clinical practice.展开更多
文摘Background: There is wide variation in the objective visual variables used to measure atopic eczema severity in clinical trials, making comparison and interpretation of results difficult. Objective: To provide a rationale for simplifying and standardizing objective atopic eczema scoring by investigating which visual variables provide the best measure of disease severity from the patient’ s perspective. Setting: The dermatology outpatient department at the Queen’ s Medical Centre, University Hospital in Nottingham, and 5 local general practices. Patients: One hundred eighty individuals with atopic eczema. Interventions: Clinical examination with scoring of 7 clinical signs and disease extent, followed by regression analyses of visual variable scores against a patient- rated measure of current disease severity. Results: Objective measurements account for only a quarter of the variation in patient- rated disease severity. Three clinical signs were independent predictors of patient- rated disease severity: excoriations, erythema, and edema/papulation. Disease extent measurements do not reflect patient- rated disease severity in a linear manner, with mean severity scores increasing little above 30% body surface area involvement. Conclusions: From the patient’ s perspective, the measurement of 3 clinical signs- excoriations, erythema, and edema/papulation- provides as much information about current atopic eczema severity as more complex scoring systems that measure multiple clinical signs and disease extent. The simplicity of the Three Item Severity score, a previously published atopic eczema score based on measurement of these 3 clinical signs, makes it a suitable tool for research studies or clinical practice.
