Calcium is important for life. Studies over the last several decades have gradually revealed the critical involvement of calcium, especially its ionic form (Ca2+), in every aspect of life forms on earth. Among them...Calcium is important for life. Studies over the last several decades have gradually revealed the critical involvement of calcium, especially its ionic form (Ca2+), in every aspect of life forms on earth. Among them, a great deal of work has been done to illustrate how Ca2+ levels are regulated in the cytoplasm and how many of the cytosolic enzymes and sig- naling molecules respond to the rise and fall of intracellular Ca2+ concentrations ([Ca2+]i). Thanks to the men and wom- en who worked tirelessly for numerous hours in the labora- tory, who made meticulous efforts to invent powerful and innovative tools, and who thought extremely hard to solve the difficult puzzles on signaling pathways, we now know so much about this spectacular cellular functioning process,展开更多
文摘Calcium is important for life. Studies over the last several decades have gradually revealed the critical involvement of calcium, especially its ionic form (Ca2+), in every aspect of life forms on earth. Among them, a great deal of work has been done to illustrate how Ca2+ levels are regulated in the cytoplasm and how many of the cytosolic enzymes and sig- naling molecules respond to the rise and fall of intracellular Ca2+ concentrations ([Ca2+]i). Thanks to the men and wom- en who worked tirelessly for numerous hours in the labora- tory, who made meticulous efforts to invent powerful and innovative tools, and who thought extremely hard to solve the difficult puzzles on signaling pathways, we now know so much about this spectacular cellular functioning process,