政府风险投资与企业下轮融资:制度逻辑效应和资源效应的权变因素探究

政府风险投资(GVC)对企业融资影响的研究是近些年创业领域的重要课题。主流文献解释了GVC投资对企业下轮融资影响中的双重作用,也阐释了不同作用发生背后潜在的制度逻辑效应和资源效应。然而,现有研究对于两种效应在何种情境下作用更强或更弱并没有进行深入探讨。为了解决这一问题,本文通过引入国有企业密度和VC往期退出率这两种情境因素,探究它们在GVC(相比于PVC)投资与企业下轮融资关系中的权变作用,以检验影响制度逻辑效应和资源效应强弱的因素。基于2010~2019年我国创业投资市场数据,本文发现GVC(相比于PVC)显著降低企业下轮融资的概率;进一步地,GVC所在地区的国有企业密度会强化GVC与企业下轮融资之间的负向关系(调节制度逻辑效应),而VC往期退出率则会弱化这一负向关系(调节资源效应)。本文通过识别影响制度逻辑效应与资源效应的权变因素,能够深化理解有关GVC(相比于PVC)与企业下轮融资关系的理论机制,也为GVC投资实践提供了一定的理论参考。

Study on prescription medication mode and mechanism of traditional Chinese medicine in the treatment of noncritical COVID-19 based on data mining

Background:As of 2023,coronavirus disease 2019(COVID-19)is still spreading globally.Therefore,we aim to integrate non-critical COVID-19 high-frequency and high-targeting Chinese medicines to provide a reference for clinical prescriptions to improve COVID-19-related symptoms.Materials and methods:The information on non-critical COVID-19 high-frequency Chinese medicines in the diagnosis and treatment of COVID-19 was obtained by the TCM inheritance support platform.Using network pharmacology and molecular docking technology,high-targeting Chinese medicines with good docking activity with COVID-19 receptors angiotensin-converting enzyme-II(ACE2),3CLpro and tyrosine-protein kinase receptor UFO(AXL)were obtained.A new prescription for non-critical COVID-19 was established by integrating high-frequency and high-targeting Chinese medicines.Rats with acute lung injury induced by lipopolysaccharide were used as the experimental model.The histopathological changes in the lungs of rats in each group were observed by hematoxylin-eosin staining.The lung coefficient of rats was measured.The levels of IL-6,TNF-α,and IL-1βin serum were detected by enzyme-linked immunosorbent assay.The mRNA and protein levels of ACE2 and AXL in lung tissue were detected by real-time quantitative polymerase chain reaction and western blot.Results:Through data mining,it was found that there were 39 high-frequency traditional Chinese medicines for non-critical COVID-19 in the diagnosis and treatment guidelines.According to network pharmacology and molecular docking,30 highly targeted traditional Chinese drugs for COVID-19 were found.The new prescriptions for non-critical COVID-19 were comprehensively obtained,including Glycyrrhizae Radix,Ephedra Herba,Amygdalus Communis Vas,Gypsum Fibrosum,Descurainiae Semen,Atractylodes Lancea,Scutellariae Radix,Amomum Tsao-Ko Crevostet,Forsythiae Fructus,Pogostemon cablin,Magnolia Officinalis.Compared with the LPS-induced lung injury model group,the medium dose of the new prescription group had significantly alleviated pathological changes in lung tissue,decreased lung coefficient,decreased contents of IL-6,TNF-αand IL-1β,and increased mRNA and protein expression of ACE2 and AXL(P<0.05).Conclusion:Based on data mining,network pharmacology and molecular docking technology,the new prescription for non-critical COVID-19 established by this method has an anti-inflammatory effect on rats with acute lung injury induced by lipopolysaccharide and can provide a reference for clinicians to alleviate the symptoms related to non-critical COVID-19.

等离子柱状电极整块切除术治疗非肌层浸润性膀胱癌的临床疗效及安全性

目的探讨非肌层浸润性膀胱癌行等离子柱状电极整块切除术的临床疗效及安全性。方法选取2014年8月-2016年7月郑州大学第二附属医院泌尿外科收治的120例非肌层浸润性膀胱癌患者为研究对象,按不同手术方式分为观察组(n=60)和对照组(n=60),分别行经尿道等离子柱状电极整块切除术和经尿道膀胱肿瘤电切术。比较两组患者围手术期临床指标、并发症及复发率。结果观察组手术时间与对照组比较,差异无统计学意义(P>0.05);观察组出血量、留置尿管时间、膀胱冲洗时间及住院天数均小于对照组(P <0.05);观察组并发症发生率和1年累计复发率为6.7%和8.3%,均低于对照组的25.0%和28.3%(P <0.05)。结论等离子柱状电极整块切除术治疗非肌层浸润性膀胱癌可有效促进患者术后恢复,降低复发率,且安全性较高。

企业创新信号与政府风险投资--基于制度逻辑视角

本文研究我国中小企业创新信号对政府风险投资(GVC)决策的影响。首先基于制度逻辑视角对我国GVC秉持的国家逻辑进行理论建构,提出GVC将投资创新企业视为重要的自身绩效衡量指标和合法性来源,并结合信号理论提出假设,认为中小企业传递的专利创新信号越强,越能获得GVC青睐。以2000~2016年我国风险投资事件为样本进行研究,结果表明:中小企业的专利数量、多样性、创新程度均正向影响GVC投资与否(相较于PVC而言)和GVC投资估值,并且当GVC的国有股权比例或本地投资占比越高时,其国家逻辑会被强化,进而增强这三种创新信号对GVC投资估值的正向影响。本文证实了我国GVC对企业创新信号的解读受国家逻辑驱动,并界定了国家逻辑发挥作用的边界条件,深化了我国情境下对GVC投资决策影响因素的理解。

A review of the treatment of ankylosing spondylitis from liver and kidney

Ankylosing spondytitis is a kind of arthropathy of rheumatic immune disease. The pathogenesis of ankylosing spondytitis is not very ctear in current medicat research. Because of the recurrence of the disease and the prolongation of the disease, the quality of tife of the patients has been seriously affected. Traditional Chinese medicine has tong known its etiotogy and pathogenesis, and it is very effective in ctinicat treatment. Based on the theory of traditional Chinese medicine and modern physicians' understanding of its etiotogy and pathogenesis, and starting from the function and characteristics of tiver and kidney, this paper explores the basis of treating ankylosing spondytitis from tiver and kidney, with a view to providing new ideas for the ctinicat treatment of ankylosing spondytitis.

How argillaceous reservoirs exhibit better quality than silty mudstones?Anomalous behavior of shale gas-bearing properties of continental fine-grained sediments in Southwest China and its possible forcing mechanisms

Achieving a thorough understanding of how primary sedimentary granularity drives considerable heterogeneity in internal reservoir attributes of terrigenous fine-grained deposits is of great significance.We investigated the quantitative differentiation and its corresponding driving forces of physical reservoir properties and pore-structure characteristics of silty-mud sediments in the Upper Triassic Xujiahe Formation(SW China)using a multi-method approach.The results show that the micro-mesopore volume and surface area of mudstones/shales are apparently higher than those of silty mudstones and a remarkable threefold rise in average permeability also presents.Extensively distributed bitumen pores occurring mostly along brittle mineral grains or forming clay-organic complexes make considerable contributions to shrinking microcracks.Furthermore,an evidently higher concentration of clay minerals in mudstone/shale reservoirs is primarily responsible for development of the two types of clay intercrystalline pores distributed along grain aggregates and between well-oriented platelets.These two major causes facilitate the formation of micro-bedding fractures/non-bedding micro fractures and connected fracture and pore-fracture networks,and also high-quality argillaceous reservoirs by strongly enhancing storage spaces and seepage capacities.Finally,a conceptual model is established for interpreting a differential reservoir-forming mechanism and corresponding two-sided effects on petrophysical and reservoir quality properties for continental silty-mud sediments.

Progress of blood-letting puncture on the treatment of psoriasis

Psoriasis is a chronic skin disease characterized by localized or wide spread squamous erythema or plaque. The pathogenesis is complicated. According to the TCM theory, psoriasis results from internal heat toxin and the deficiency of blood. And blood stasis exists throughout the disease, the treatment should focus on promoting blood circulation and removing blood stasis. Blood-letting puncture can balance Qi and blood through stimulating the meridians, forcing evil Qi to go out, so as to dispel pathogenic factors and dredge the meridians. This article briefly discusses the basic mechanisms and clinical researches of psoriasis with blood-letting puncture, in order to provide new ideas for the clinical treatment of psoriasis.

A meta-analysis of Banxia Xiexin decoction versus omeprazole in the treatment of gastroesophageal reflux disease

Objective:To investigate the clinical efficacy and safety of Banxia Xiexin decoction and omeprazole in the treatment of gastroesophageal reflux disease(GERD).Methods:EMbase,Cochrane,PubMed,CNKI,Wan Fang and VIP database were searched from inception to November 2018 according to the search strategy.Eligible randomized controlled clinical trials related to the efficacy of omeprazole compared with Banxia Xiexin decoction in the treatment of GERD were included according to the inclusion and exclusion criteria.Total effective rate,pathological improvement rate,total symptom score,acid reflux symptoms,heartburn symptoms,improvement of post-sternal pain symptoms,and incidence of adverse reactions were evaluated.Data analysis was performed with RevMan5.3 software provided by Cochrane Collaboration.Results:A total of 15 studies were enrolled,including 1,532 patients.Meta-analysis results showed that the total effective rate of Banxia Xiexinfang was higher than that of omeprazole in the treatment of GERD(odds ratio(OR)=3.99,95%confidence intervals(CI)(2.58,6.15),P<0.00001).Pathological improvement under endoscopy was not obvious(OR=1.98,95%CI(0.94,4.19),P=0.07)between the two groups.The total symptom score improved significantly,indicating that Banxia Xiexin decoction has an objective advantage over omeprazole in the treatment of GERD(standardised mean difference(SMD)=?2.56,95%CI(?3.86,?1.26),P=0.0001),The incidence of adverse reactions in patients treated with Banxia Xiexin decoction is lower than omeprazole group(OR=0.09,95%CI(0.02,0.39),P=0.001].In addition,total effective rate of Banxia Xiexin decoction combined with omeprazole was higher than omeprazole alone(OR=6.31,95%CI(2.86,13.92),P<0.00001).Conclusion:Banxia Xiexin decoction is superior to omeprazole in total effective rate,total symptom score and adverse reaction rate in the treatment of GERD.The clinical efficacy of Banxia Xiexin decoction combined with omeprazole is better than that of omeprazole alone.However,due to the low quality of the included literatures,large-scale and high-quality RCTs are still needed for further confirmation.

The law of the prescription for non-alcoholic steatohepatitis: a data mining analysis

Objective:This study aimed to explore the law of the prescription for non-alcoholic steatohepatitis and provide ideas for the clinical application.Methods:This study searched CNKI,Wanfang,CBM,VIP,Web Of Science,PubMed,Elsevier to identify the studies published in nearly three years.The Chinese Medicine Heritage Supporting Platform(V2.5)was used to analyze traditional Chinese medicines used in the treatment of nonalcoholic steatohepatitis prescriptions and their combination rules,extract core combinations to form a new formula.Results:A total of 58 commonly used prescriptions for the treatment of non-alcoholic steatohepatitis were retrieved,including 96 flavors of traditional Chinese medicine.Data mining showed that Chinese medicine with frequency≥6 had a total of 21 flavors,and common pairs of drugs and 26 pairs were used to treat nonalcoholic steatohepatitis.The core drug combination was 6 pairs and evolved into a new party with 3 pairs.Conclusion:The traditional Chinese medicine inheritance platform system has important value for the clinical trial of traditional Chinese medicine for the treatment of nonalcoholic steatohepatitis.The new evolution of the Chinese medicine provides a new idea for the clinical treatment of non-alcoholic steatohepatitis.

History and Modern Application of Chinese Physical and Breathing Exercises

Traditional Chinese medicine is the key to open the treasure house of Chinese civilization.Traditional Chinese medicine treatment includes drugs,acupuncture,massage,cupping and other means.Chinese physical and breathing exercises is one of the most effective methods of exercise among various treatments.Chinese physical and breathing exercises can soften muscles and strengthen bones.It has the functions of activating blood circulation and regulating the internal organs and internal organs.It can enhance physical fitness,prevent disease and cure diseases,and achieve the purpose of prolonging life.In order to provide guidance for the prevention and treatment of clinical diseases,this paper summarized the literature records,theoretical basis,clinical application and related literature reports of Chinese physical and breathing exercises.

Diagnosis and treatment of psoriatic arthritis with concealed rash: a case report

银屑病关节炎是一种与银屑病相关的关节炎,其临床表现中以关节炎为首发症状的银屑病关节炎常与强直性脊柱炎、类风湿关节炎具有相似之处,在诊断时应加以鉴别,提高治疗疗效。银屑病关节炎皮损常见丘疹或斑块,表面附有鳞屑,基底有点状出血的特点,临床约有10%患者皮疹出现在关节炎发病之后。现结合1则皮疹隐匿的银屑病关节炎病案及相关文献报道,对其临床诊断进行分析,以期为临床医师在诊断银屑病关节炎方面提供参考。

Rheumatoid arthritis and ankylosing spondylitis occurring together: a case report

强直性脊柱炎和类风湿关节炎是两种不同的风湿免疫性疾病,同时患病于同一患者,在临床上比较少见,我科最近收治此病1例并给予中西医结合治疗,患者症状得到有效改善,现将病例报告如下。

Photovoltaics and Energy Storage Integrated Flexible Direct Current Distribution Systems of Buildings:Definition,Technology Review,and Application

For a future carbon-neutral society,it is a great challenge to coordinate between the demand and supply sides of a power grid with high penetration of renewable energy sources.In this paper,a general power distribution system of buildings,namely,PEDF(photovoltaics,energy storage,direct current,flexibility),is proposed to provide an effective solution from the demand side.A PEDF system integrates distributed photovoltaics,energy storages(including traditional and virtual energy storage),and a direct current distribution system into a building to provide flexible services for the external power grid.System topology and control strategies at the grid,building,and device levels are introduced and analyzed.We select representative work about key technologies of the PEDF system in recent years,analyze research focuses,and summarize their major challenges&future opportunities.Then,we introduce three real application cases of the PEDF system.On-site measurement results demonstrate its feasibility and advantages.With the rapid growth of renewable power production and electric vehicles,the PEDF system is a potential and promising approach for largescale integration of renewable energy in a carbon-neutral future.

A general powder dusting method for latent fingerprint development based on AIEgens

Powder dusting method is the most practically useful approach for latent fingerprint development in the crime scene. Herein, a general powder dusting method has been explored for latent fingerprint development based on aggregation-induced emission luminogens(AIEgens). A series of tetraphenylethene(TPE) derivatives with multiple diphenylamine(DPA), namely, TPE-DPA,TPE-2 DPA and TPE-4 DPA, were selected as candidates to dope with magnetic powders and applied for latent fingerprint development. After screening, the magnetic powder 3 doped with TPE-4 DPA proves to be the best, in terms of fluorescent intensity, resolution and adhesiveness. Afterwards, the magnetic powder 3 was applied for visualization of latent fingerprint on various smooth and porous substrates, including glass, stainless steel, leaf, ceram, plastic bag, lime wall, wood and paper money.Specific details, such as island, core, termination and bifurcation, can be clearly observed for the fluorescent fingerprint images.

Production of Fibres from Lunar Soil:Feasibility,Applicability and Future Perspectives

The construction of a lunar base is considered to be an important step towards deep-space exploration by humanity,and will rely on the utilisation of in situ lunar resources.In this paper,we discuss the current knowledge on the feasibility of converting lunar soil to high-performance fibres that can be used for the construction of a lunar base.This fibre would be combined with further portions of lunar soil to generate fibre-reinforced composites,which is utilized as multi-functional materials for lunar base construction.We discuss and analyse the latest findings regarding the composition of lunar soil simulants and their fibrisation properties,and techniques for fibre spinning and system integration.Finally,we suggest how the achievements made so far could be applied to the construction of a lunar base.

Aggregation-induced demulsification triggered by the hydrophilic fabric for the separation of highly emulsified oil droplets from water

A functional fabric with hierarchical structure consisting of basalt fibre fabric as a substrate and polyvinyl alcohol as a coating was developed,aiming at providing a low cost and high-performance way to separate highly emulsified oil in water.The coating functioned as a hydrophilic gate for the penetration of water in the emulsion,whereas the micro-channels formed in the fabric offered capillary force for the continuous flow of water.The synergy of these two materials led to the increase on the oil concentration in the liquid,which in turn enhanced the collision of emulsified oil droplets to aggregate into large ones in the emulsion and resulted separation from the water.Based on these findings,an aggregation-induced demulsification process was proposed to explain the above phenomenon,and the mechanism was confirmed by studying the distribution of oil droplets in emulsion with a controlled separation degree.

Bitumen formation of Cambrian Longwangmiao Formation in the central Sichuan and its implication for hydrocarbon accumulation

Based on organic petrology,organic geochemistry and SEM method,type,formation period and source of bitumens in the Cambrian Longwangmiao Formation in the central Sichuan Basin were well investigated,and combined with fluid inclusions and tectonic evolution characteristics,the hydrocarbon accumulation history of the gas reservoir of the Longwangmiao Formation in the Anyue gasfield was also studied.The result shows that all bitumens in the Longwangmiao Formation was from the Lower Cambrian source rocks,it had multiple genetic types which was dominated by the pyrolysis genetic type;the bitumens were formed into three stages,i.e.,the bitumen of the oxidized water-washing type in the first stage,the bitumen of the precipitated type in the second stage,and the bitumen of the pyrolyzed type in the third stage;the gas reservoir in the Anyue gasfield experienced five stages of hydrocarbon charging,including two stages of liquid hydrocarbon charging,charging of the kerogen pyrolysis gas in the Late Triassic-Early Jurassic,charging of the crude oil pyrolysis gas in the Late Jurassic-Early Cretaceous and charging of the dry gas charging in the Himalayan trap reformation and adjustment process.

Expression and clinical implication of PRL-1 and PRL-3 in transitional cell carcinoma of bladder

The mRNA and protein expression of phos-phatase of regenerating liver 1(PRL-1)and phosphatase of regenerating liver 3(PRL-3)in transitional cell carcinoma of bladder(BTCC)and normal epithelia of bladder was investigated,and the relationship between the BTCC and pathological changes was clarified.The expression of PRL-1 and PRL-3 mRNA was detected by using reverse transcription polymerase chain reaction(RT-PCR)in 30 cases of BTCC and 10 cases of normal bladder,and the expression of PRL-1 and PRL-3 protein was checked by using immunohistochemistry in 30 cases of BTCC and 15 cases of normal bladder.The expression levels of PRL-1 and PRL-3 mRNA and protein were higher in BTCC than those in normal bladder epithelia(P<0.05).The increased expression of PRL-1 and PRL-3 mRNA and protein was detectable in deep invasion and metastasis of BTCC(P<0.05).There was no correlation between the expres-sion of PRL-1 and PRL-3 and gender,age or recurrence of BTCC(all P>0.05).A significantly positive correlation was found between PRL-1 and PRL-3 in BTCC(P<0.05).PRL-1 and PRL-3 are expressed consistently and may contribute to the growth,differentiation,invasion and metastasis of BTCC.

A Novel Analytical Method of 1‑(3‑Trifluoromethylphenyl)piperazine and 1‑(3‑Chlorophenyl)piperazine in Fluids of Drug Addicts Using Liquid‑liquid Extraction–gas Chromatographic/Nitrogen–phosphorous Detection

In accordance with the research specifications and guidelines in China,we developed a novel experimental method to detect new piperazine‑type drugs,such as 1‑(3‑trifluoromethylphenyl)piperazine and 1‑(3‑chlorophenyl)piperazine.In this study,a new pretreatment method and gas chromatography(GC)/nitrogen–phosphorus detector detection technique were used to characterize these two kinds of drugs in urine and blood samples.For the purpose of isolation of these trace drugs from the samples,liquid‑liquid extraction/solid‑phase extraction was modified and validated for this specific study.The pretreatment method presented in this paper has many advantages,such as high recovery rate,high extraction efficiency,high detection sensitivity,low limit of detection,and simple operation.The GC/NPD instrument is popular in most laboratories because it can meet the routine requirements of forensic science.All these aspects make this combination of sample pretreatment and GC/NPD technique the most suitable choice for drug detection in biological samples.