渗透率各向异性气藏井网设计与调整研究

渗透率各向异性在气藏的开发过程中起着不容忽视的作用。以长庆油田某气藏为例，结合渗透率各向异性的理论基础，探索了渗透率各向异性气藏井网调整方法。其具体做法是，首先通过坐标变换将现有各向异性井网转化为等价各向同性井网，对现有井网的适应性进行评价；然后根据区块储层物性，建立各向同性机理模型来优选各向同性最优井网；最后在各向同性井网设计结果的基础上通过坐标变换设计得到适合气藏各向异性的最优井网。

Role of Wnt/β-Catenin Pathway in the Arterial Medial Calcification and Its Effect on the OPG/RANKL System

In this study,the hypothesis that Wnt/β-catenin pathway is involved in the arterial calcification by regulating the osteoprotegerin(OPG)/receptor activator of NF-κB ligand(RANKL)system was tested.Theβ-catenin expression was measured in the warfarin-induced calcified arteries and the osteoblast-like cells differentiating from smooth muscle cells(SMCs)by immunohistochemistry and Western blotting.The Wnt/β-catenin pathway was activated or inhibited by lithium chloride(LiCl)or dickkopf 1(DKK1)in vitro and in vivo.Then the calcification level was determined by von Kossa staining,Ca^2+content assay,and alkaline phosphatase(ALP)activity assay.The expression levels of osteocalcin,OPG and RANKL were detected by Western blotting or real-time PCR.The results showed that in calcified arteries and OBL cells,the activation of Wnt/β-catenin pathway significantly enhanced the calcification as evidenced by increased von Kossa stains,Ca^2+contcnts,ALP activities,and osteocalcin expression levels(P<0.05),and it promoted the RANKL expression(P<0.05),but slightly affected the OPG expression.These results indicated that the activation of Wnt/β-catenin pathway worsens the arterial calcification,probably by promoting the RANKL expression.

Preparation and functional study of pH-sensitive amorphous calcium phosphate nanocarriers

Recently,multifunctional nanoparticles have shown great prospects in cancer treatment,which have the ability to simultaneously deliver the drug,image and target tumor cells.In this paper,we designed a luminescent nanoparticles platform based on hydrothermal hyaluronic acid/amorphous calcium phosphate(HA-FCNs/ACP)with multifunctional properties for drug delivery,bio-imaging,and targeting treatment.HA-FCNs/ACP shows an ability to load curcumin(Cur)with pH-sensitive responsive drug release behavior and excellent biocompatibility.HA-FCNs/ACP dispersed in the cytoplasm through the overexpressed CD44 receptor that is actively targeted into human lung cancer cells(A549 cells).Meanwhile,the viability of A549 cells was significantly inhibited in vitro.The prepared HA-FCNs and HA-FCNs/ACP both exhibit excellent targeted bioimaging performance on cancer cells.Hence,the as-prepared nanoparticles have promising applications in treating tumor disease.

医工融合专业创新能力培养的组织建设研究与探索

为了保障创新能力的培养,支持人才创新培养模式的开展,以医工融合专业为例,探讨创新教育中组织管理体系的建设,根据专业和学生需求,在人才培养过程中实施基于需求的分目标的创新培养,有针对性完善创新组织管理,建立组织保障机制,建设创新型人才培养的组织管理体系。

Effect of sodium alginate/phosphate-stabilized amorphous calcium carbonate nanoparticles on chitosan membranes

Biodegradable chitosan(CS)films can meet the demand for sustainable development.However,the performance of pure CS membrane still exists a particular gap compared with the traditional film.Inorganic nanomaterials with the controllable release are added to improve its physical and chemical properties.Herein,a series of CS/phosphate-stabilized amorphous calcium carbonate(CS/ACCP)and CS/sodium alginate/ACCP(CS/Alginate/ACCP)composite films were prepared by the flow method.The effects of ACCP and Alginate/ACCP nanoparticles on the physical and chemical properties of the composite membrane were investigated.The results showed that the composite nanoparticles could significantly improve CS film’s compactness,hydrophobicity,and mechanical properties and enhance its ultraviolet(UV)blocking ability,water resistance,and water vapor blocking ability.When the number of nanoparticles was 8%,the mechanical properties of the CS composite membrane reached optimum value,and the comprehensive performance was better.In addition,the controlled-release properties of CS composite membranes were also studied,and the antioxidant,antibacterial,biocompatibility,and fresh-keeping effects of the composite membranes were explored.The results indicated that the CS composite membranes had not only excellent bacteriostatic(72%)properties(Escherichia coli)but also presented well fruit preservation(15 days)properties(sugar orange).In particular,the controlled release range of CS composite membrane at 12 h was between 30%and 90%,which provided a theoretical basis for its use as an edible membrane.Therefore,based on ACCP and Alginate/ACCP nanoparticles,CS composite membranes with more excellent application value in the biological field were prepared through further optimization design.

Coupling Magneto-Electro-Elastic node-based smoothed radial point interpolation method for free vibration and transient analysis of Functionally Graded Magneto-Electro-Elastic structures

A Coupling Magneto-Electro-Elastic(MEE)Node-based Smoothed Radial Point Interpolation Method(CM-NS-RPIM)was proposed to solve the free vibration and transient responses of Functionally Graded Magneto-Electro-Elastic(FGMEE)structures.By introducing the modified Newmark method,the displacement,electrical potential and magnetic potential of the structures under transient mechanical loading were obtained.Based on G space theory and the weakened weak(W2)formulation,the equations of the multi-physics coupling problems were derived.Using triangular background elements,the free vibration and transient responses of three numerical examples were studied.Results proved that CM-NS-RPIM performed better than the standard FEM by reducing the overly-stiff of structures.Moreover,CM-NS-RPIM could reduce the number of nodes while guaranteeing the accuracy.Besides,triangular elements could be generated automatically even for complex geometries.Therefore,the effectiveness and validity of CM-NS-RPIM were demonstrated,which were valuable for the design of intelligence devices,such as energy harvesters and sensors.