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Evaluation of elastography combined with serological indexes for hepatic fibrosis in patients with chronic hepatitis B 被引量:23
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作者 bin xu Ning-Ming Zhou +1 位作者 Wei-Tian Cao Xiao-Jing Li 《World Journal of Gastroenterology》 SCIE CAS 2018年第37期4272-4280,共9页
AIM To investigate the value of ultrasound elastography combined with serological indexes in diagnosing liver fibrosis and assessing its severity.METHODS A total of 338 chronic hepatitis B(CHB) patients were divided i... AIM To investigate the value of ultrasound elastography combined with serological indexes in diagnosing liver fibrosis and assessing its severity.METHODS A total of 338 chronic hepatitis B(CHB) patients were divided into a disease group(patients with hepatic fibrosis) and control group(subjects without hepatic fibrosis). The disease group was further divided into S1-S4 according to the degree of fibrosis. Independent risk factors for hepatic fibrosis were analyzed using multivariate logistic regression. The diagnostic values of hepatic fibrosis from different indicators were compared using receiver operating characteristic(ROC) curves. The combination of elastography and serological indexes was explored to assess the severity of hepatic fibrosis.RESULTS The multivariate logistic regression analysis results revealed that shear wave velocity(SWV), hyaluronic acid(HA), type Ⅳ collagen(CⅣ) and aspartate aminotransferase-to-platelet ratio index(APRI) significantly affected the occurrence of hepatic fibrosis. The ROC curve revealed that the accuracy of the diagnosis of hepatic fibrosis for SWV and HA were 87.3% and 84.8%, respectively. The accuracy of SWV combined with HA was 88.9%. The multiple linear regression analysis revealed that SWV, aspartate aminotransferase(AST)/alanine aminotransferase(ALT), HA, CⅣ, APRI and fibrosis index based on the 4 factor(FIB-4) were screened as statistically significant independent factors. The established regression equation was: Fibrosis level =-4.046 + 1.024 × SWV + 1.170 × AST/ALT + 0.011 × HA + 0.020 × CⅣ + 0.719 × APRI + 0.379 × FIB-4. CONCLUSION SWV combined with serological indexes can improve the accuracy of diagnosis for CHB hepatic fibrosis. Serum indexes can help diagnose the degree of hepatic fibrosis. 展开更多
关键词 ELASTOGRAPHY SEROLOGY HEPATIC FIBROSIS NON-INVASIVE diagnosis
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Effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus in rats with irritable bowel syndrome with constipation 被引量:3
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作者 Liting Zhu Zhonghan Li +4 位作者 bin xu Chen Xia Jie Cheng Xiaoren Xiang Yi Zhu 《Neural Regeneration Research》 SCIE CAS CSCD 2011年第33期2605-2609,共5页
We studied the effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus and on defecation in rats with irritable bowel syndrome with constipation (IBS-C). We also used intragastr... We studied the effects of electroacupuncture at Zusanli (ST 36) on neurons in the colonic myenteric plexus and on defecation in rats with irritable bowel syndrome with constipation (IBS-C). We also used intragastric administration of pinaverium bromide as a positive control treatment to reveal the pathway mediating the onset of IBS-C. Both electroacupuncture and pinaverium bromide greatly improved defecation in rats with IBS-C. Immunohistochemical staining of the enteric nervous system neuronal marker protein gene product 9.5 in the colonic myenteric plexus showed that electroacupuncture by itself, or in combination with pinaverium bromide, increased the number of neurons and the staining intensity of protein gene product 9.5 in the colonic myenteric plexus. We conclude that visceral hypersensitivity is likely to be a primary cause of constipation in IBS-C rats. 展开更多
关键词 ELECTROACUPUNCTURE irritable bowel syndrome with constipation colonic myenteric plexus NEURONS pinaverium bromide DEFECATION neural regeneration
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Composite wave-absorbing structure combining thin plasma and metasurface
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作者 郝志安 李健飞 +5 位作者 徐彬 姚静锋 袁承勋 王莹 周忠祥 王晓鸥 《Plasma Science and Technology》 SCIE EI CAS CSCD 2023年第4期148-155,共8页
In order to solve the thickness dependence of plasma absorption of electromagnetic waves and further reduce the backward radar scattering cross section(RCS)of the target,we designed a novel composite structure of a me... In order to solve the thickness dependence of plasma absorption of electromagnetic waves and further reduce the backward radar scattering cross section(RCS)of the target,we designed a novel composite structure of a metasurface and plasma.A metasurface with three absorption peaks is designed by means of an equivalent circuit based on an electromagnetic resonance type metamaterial absorber.The reflection and absorption of the composite structure are numerically and experimentally verified.The finite integration method was used to simulate a composite structure of finite size to obtain the RCS.The experimental measurements of electromagnetic wave reflection were conducted by a vector network analyzer(Keysight N5234A)and horn antennas,etc.The research showed that the absorption capacity of this composite structure was substantially improved compared to either the plasma or the metasurface,and it is more convenient for application due to its low plasma thickness requirement and easy fabrication. 展开更多
关键词 PLASMA metasurface composite structure radar scattering cross section
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黄钾铁矾对硫脲浸金的影响及草酸盐的作用机理 被引量:1
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作者 李科 李骞 +4 位作者 姜涛 杨永斌 徐斌 许瑞 张雁 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第1期322-335,共14页
研究生物氧化产生的黄钾铁矾对酸性硫脲浸金的影响,并探讨草酸添加剂的作用机制。结果表明,黄钾铁矾会增加硫脲的消耗和阻碍金的溶解。黄钾铁矾能显著提高硫脲的分解,阻碍金的溶解。黄钾铁矾造成不利影响的主要原因可能是酸性溶液中黄... 研究生物氧化产生的黄钾铁矾对酸性硫脲浸金的影响,并探讨草酸添加剂的作用机制。结果表明,黄钾铁矾会增加硫脲的消耗和阻碍金的溶解。黄钾铁矾能显著提高硫脲的分解,阻碍金的溶解。黄钾铁矾造成不利影响的主要原因可能是酸性溶液中黄钾铁矾释放的铁离子使溶液浆电位增加,从而加速硫脲的分解,并加剧硫脲分解产生的钝化物种对金表面的钝化作用。添加草酸盐可以有效削弱黄钾铁矾的不利影响,表现为明显降低硫脲的消耗和促进金的溶解。通过溶液电位、Zeta电位和XPS分析,揭示草酸的可能作用机理。草酸盐不仅可以通过与Fe^(3+)配位减弱Fe^(3+)与硫脲之间的相互作用,还可以通过无差别吸附和静电斥力阻止钝化产物在金表面包裹。 展开更多
关键词 生物黄钾铁矾 金浸出 硫脲消耗 草酸盐
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3D Foam-Based MXene Architectures:Structural and Electrolytic Engineering for Advanced Potassium-Ion Storage 被引量:1
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作者 Peng Zhang Yanmeng Peng +3 位作者 Qizhen Zhu Razium Ali Soomro Ning Sun bin xu 《Energy & Environmental Materials》 SCIE EI CAS CSCD 2024年第4期64-73,共10页
MXenes are emerging rapidly as promising electrode materials for energy storage due to their high electronic conductivity and rich surface chemistry,but their potassium storage performance is unsatisfactory because of... MXenes are emerging rapidly as promising electrode materials for energy storage due to their high electronic conductivity and rich surface chemistry,but their potassium storage performance is unsatisfactory because of the large size of K^(+)and irreversible interfacial reaction.Here,a developed 3D foam-like MXene scaffold(3D-FMS)is constructed via an electrostatic neutralization of Ti_(3)C_(2)T_(x)with positive-charged melamine followed with calcination,which offers massive surface-active sites and facilitates fast K^(+)transfer for boosting the potassium-ion storage capacity and dynamics.In addition,using KFSI-based electrolyte,the formation of a robust solid electrolyte interface layer with more inorganic components on MXene anode is revealed for enhancing the Coulombic efficiency.Consequently,the 3DFMS with KFSI-based electrolyte delivers enhanced potassium-ion storage performance in terms of capacity(161.4 mAh g^(-1)at 30 mA g^(-1)),rate capability(70 mAh g^(-1)at 2 A g^(-1)),and cycling stability(80.5 mAh g^(-1)at 1 A g^(-1)after 2000 cycles).Moreover,the assembled 3D-FMS//activated carbon potassium-ion hybrid supercapacitor delivers a high energy density of 57 Wh kg^(-1)at a power density of 290 W kg^(-1).These excellent performances demonstrate the great superiority of 3D-FMS in KFSI-based electrolyte and may accelerate the development of MXene-based materials for potassium storage systems. 展开更多
关键词 3D foam-like scaffold electrolyte chemistry electrostatic neutralization MXene potassium-ion batteries
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Mutational landscape of TP53 and CDH1 in gastric cancer 被引量:1
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作者 Hong-Qiao Cai Li-Yue Zhang +2 位作者 Li-Ming Fu bin xu Yan Jiao 《World Journal of Gastrointestinal Surgery》 SCIE 2024年第2期276-283,共8页
In this editorial we comment on an article published in a recent issue of the World J Gastrointest Surg.A common gene mutation in gastric cancer(GC)is the TP53 mutation.As a tumor suppressor gene,TP53 is implicated in... In this editorial we comment on an article published in a recent issue of the World J Gastrointest Surg.A common gene mutation in gastric cancer(GC)is the TP53 mutation.As a tumor suppressor gene,TP53 is implicated in more than half of all tumor occurrences.TP53 gene mutations in GC tissue may be related with clinical pathological aspects.The TP53 mutation arose late in the progression of GC and aided in the final switch to malignancy.CDH1 encodes E-cadherin,which is involved in cell-to-cell adhesion,epithelial structure maintenance,cell polarity,differentiation,and intracellular signaling pathway modulation.CDH1 mutations and functional loss can result in diffuse GC,and CDH1 mutations can serve as independent prognostic indicators for poor prognosis.GC patients can benefit from genetic counseling and testing for CDH1 mutations.Demethylation therapy may assist to postpone the onset and progression of GC.The investigation of TP53 and CDH1 gene mutations in GC allows for the investigation of the relationship between these two gene mutations,as well as providing some basis for evaluating the prognosis of GC patients. 展开更多
关键词 TP53 CDH1 Gastric cancer Gene mutation METHYLATION
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Adsorption behaviors and mechanisms of gold recovery from thiosulfate solution by ion exchange resin
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作者 Zhong-lin DONG Tao JIANG +2 位作者 bin xu Qian LI Yong-bin YANG 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2024年第10期3372-3385,共14页
The adsorption behaviors and mechanisms of gold from thiosulfate solution on strong-base anion exchange resin were systematically investigated.The comparison experiment of adsorption ability and selectivity for gold s... The adsorption behaviors and mechanisms of gold from thiosulfate solution on strong-base anion exchange resin were systematically investigated.The comparison experiment of adsorption ability and selectivity for gold showed that gel Amberlite IRA-400 resin with Type Ⅰ quaternary ammonium functional group had better adsorption performance.The increases of resin dosage,ammonia concentration and solution pH were favorable to gold adsorption,whereas the rises of cupric and thiosulfate concentrations were disadvantageous to gold loading.Microscopic characterization results indicated that gold was adsorbed in the form of [Au(S_(2)O_(3))_(2)]^(3–) complex anion by exchanging with the counter ion Cl^(–) in the functional group of the resin.Density functional theory calculation result manifested that gold adsorption was mainly depended on the hydrogen bond and van der Waals force generated between O atom in [Au(S_(2)O_(3))_(2)]^(3–) and H atom in the quaternary ammonium functional group of the resin. 展开更多
关键词 GOLD thiosulfate solution resin adsorption behaviors and mechanisms density functional theory calculation
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Stability of bedded rock slopes subjected to hydro-fluctuation and associated strength deterioration
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作者 bin xu Xinrong Liu +2 位作者 Yue Liang Xiaohan Zhou Zuliang Zhong 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第8期3233-3257,共25页
Reservoir-induced earthquakes(RIEs)occur frequently in the Three Gorges Reservoir Area(TGRA)and the rock mass strength of the hydro-fluctuation belt(HFB)deteriorates severely due to the reservoirinduced seismic loads.... Reservoir-induced earthquakes(RIEs)occur frequently in the Three Gorges Reservoir Area(TGRA)and the rock mass strength of the hydro-fluctuation belt(HFB)deteriorates severely due to the reservoirinduced seismic loads.Three models of typical bedded rock slopes(BRSs),i.e.gently(GIS),moderately(MIS),and steeply(SIS)inclined slopes,were proposed according to field investigations.The dynamic response mechanism and stability of the BRSs,affected by the rock mass deterioration of the HFB,were investigated by the shaking table test and the universal distinct element code(UDEC)simulation.Specifically,the amplification coefficient of the peak ground acceleration(PGA)of the slope was gradually attenuated under multiple seismic loads,and the acceleration response showed obvious“surface effect”and“elevation effect”in the horizontal and vertical directions,respectively.The“S-type”cubic function and“steep-rise type”exponential function were used to characterize the cumulative damage evolution of the slope caused by microseismic waves(low seismic waves)and high seismic waves,respectively.According to the dynamic responses of the acceleration,cumulative displacement,rock pressure,pore water pressure,damping ratio,natural frequency,stability coefficient,and sliding velocity of the slope,the typical evolution processes of the dynamic cumulative damage and instability failure of the slope were generalized,and the numerical and experimental results were compared.Considering the dynamic effects of the slope height(SH),slope angle(SA),bedding plane thickness(BPT),dip angle of the bedding plane(DABP),dynamic load amplitude(DLA),dynamic load frequency(DLF),height of water level of the hydro-fluctuation belt(HWLHFB),degradation range of the hydro-fluctuation belt(DRHFB),and degradation shape of the hydro-fluctuation belt(DSHFB),the sensitivity of factors influencing the slope dynamic stability using the orthogonal analysis method(OAM)was DLA>DRHFB>SA>SH>DLF>HWLHFB>DSHFB>DABP>BPT. 展开更多
关键词 Bedded rock slopes Hydro-fluctuation belt Shaking table test UDEC simulation Dynamic response mechanism
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Mussel-inspired PTW@PDA composites for developing high-energy gun propellants with reduced erosion and enhanced mechanical strength
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作者 Xijin Wang Zhitao Liu +3 位作者 Pengfei Sun Feiyun Chen bin xu Xin Liao 《Defence Technology(防务技术)》 SCIE EI CAS CSCD 2024年第2期675-690,共16页
The severe erosion and inadequate mechanical strength are prominent challenges for high-energy gun propellants.To address it,novel PTW@PDA composites was prepared by polydopamine(PDA)-modifying onto potassium titanate... The severe erosion and inadequate mechanical strength are prominent challenges for high-energy gun propellants.To address it,novel PTW@PDA composites was prepared by polydopamine(PDA)-modifying onto potassium titanate whisker(PTW,K_(2)Ti_(6)O_(13)),and after was incorporated into gun propellant as erosion-reducing and mechanical-reinforcing fillers.The interfacial characterizations results indicated that as-prepared PTW@PDA composites exhibits an enhanced surface compatible with propellant matrix,thereby facilitating their dispersion into propellants more effectively than raw PTW materials.Compared to original propellants,PTW@PDA-modified propellants exhibited significant less erosion,with a Ti-Kbased protective coating being detected on the eroded steel.And 0.5 wt%and 1.0 wt%addition of PTW@PDA significantly improved impact,compressive and tensile strength of propellants.Despite the inevitably reduction in relative force,PTW@PDA slightly increase propellant burning rate while exerting little adverse impact on propellant dynamic activity.This strategy can provide a promising alternative to develop high-energy gun propellant with less erosion and more mechanical strength. 展开更多
关键词 High energy gun propellant Potassium titanate whiskers Polydopamine modification Erosion inhibitors Mechanical reinforcing fillers
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The storage and utilization of carbohydrates in response to elevation mediated by tree organs in subtropical evergreen broad-leaved forests
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作者 bin xu xueli Jiang +4 位作者 Yingying Zong G.Geoff Wang Fusheng Chen Zhenyu Zhao Xiangmin Fang 《Forest Ecosystems》 SCIE CSCD 2024年第1期52-61,共10页
Global climate change can affect tree growth and carbon sink function by influencing plant carbohydrate synthesis and utilization,while elevation can be used as an ideal setting under natural conditions to simulate cl... Global climate change can affect tree growth and carbon sink function by influencing plant carbohydrate synthesis and utilization,while elevation can be used as an ideal setting under natural conditions to simulate climate change effects.The effect of elevation on tree growth may depend on organ type.However,the allocation patterns of nonstructural and structural carbohydrates(NSCs and SCs,respectively)in different tree organs and their response to elevation remain unclear.We selected four dominant tree species,Schima superba,Castanopsis eyrei,Castanopsis fargesii and Michelia maudiae,along an elevation gradient from 609 to 1,207 m in subtropical evergreen broad-leaved forests and analyzed leaf,trunk,and fine root NSCs,carbon(C),nitrogen(N)and phosphorus(P)concentrations and the relative abundance of SCs.Leaf NSCs increased initially and then decreased,and trunk NSCs increased with increasing elevation.However,root NSCs decreased with increasing elevation.The relative abundance of SCs in leaves and trunks decreased,while the relative abundance of root SCs increased with increasing elevation.No significant correlations between SCs and NSCs in leaves were detected,while there were negative correlations between SCs and NSCs in trunks,roots,and all organs.Hierarchical partitioning analysis indicated that plant C/N and C/P were the main predictors of changes in SCs and NSCs.Our results suggest that tree organs have divergent responses to elevation and that increasing elevation will inhibit the aboveground part growth and enhance the root growth of trees.A tradeoff between the C distribution used for growth and storage was confirmed along the elevation gradient,which is mainly manifested in the"sink"organs of NSCs.Our results provide insight into tree growth in the context of global climate change scenarios in subtropical forest ecosystems. 展开更多
关键词 Nonstructural carbohydrates Structural carbohydrates ELEVATION Subtropical evergreen broad-leaved forests Tree organs
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MAPK9 as a therapeutic target:unveiling ferroptosis in localized prostate cancer progression
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作者 CHENG-GONG LUO JIAO ZHANG +10 位作者 YUN-ZHAO AN xuAN LIU SHUAI-JIE LI WEI ZHANG KAI LI xu ZHAO DONG-BO YUAN LING-YUE AN WEI CHEN YE TIAN bin xu 《BIOCELL》 SCIE 2024年第5期771-792,共22页
Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehens... Background:Ferroptosis,a lipid peroxidation-mediated programmed cell death,is closely linked to tumor development,including prostate cancer(PCa).Despite established connections between ferroptosis and PCa,a comprehensive investigation is essential for understanding its impact on patient prognosis.Methods:A risk model incorporating four ferroptosis-related genes was developed and validated.Elevated risk scores correlated with an increased likelihood of biochemical recurrence(BCR),diminished immune infiltration,and adverse clinicopathological characteristics.To corroborate these results,we performed validation analyses utilizing datasets from both the Cancer Genome Atlas Cohort(TCGA)and the Gene Expression Synthesis Cohort(GEO).Moreover,we conducted further investigations into the pivotal gene identified in our model to explore its impact on tumor characteristics through cell proliferation and invasion assays,as well as animal studies conducted in vivo.Additionally,we conducted further experiments involving ferroptosis-related analysis to validate its association with ferroptosis.Results:The risk model demonstrated exceptional predictive capabilities for prognosis and therapeutic outcomes in PCa patients.Mitogen-activated protein kinase 9(MAPK9)emerged as a crucial gene within the model.In vivo and in vitro experiments explored MAPK9’s role in ferroptosis and its influence on tumor migration and proliferation.Conclusion:The findings provide a novel perspective for advancing ferroptosis exploration in PCa,bridging basic research and clinical applications. 展开更多
关键词 Ferroptosis Biochemical recurrence Prostate cancer TCGA GEO MAPK9
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Autophagy Alleviates Cold Exposure-induced Tight Junction Injury in Murine Ileum
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作者 Jingru Guo Jing xu +7 位作者 Leichong Chen Huijie Hu Junshu Nie Jianbin Yuan Li Ma Jingjing Lu Hong Ji bin xu 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2024年第7期800-804,共5页
Cold exposure is a pervasive stressor in the polar and subpolar regions,exerting both acute and chronic effects on individuals.This environmental factor is known to induce physiological stress,compromise immune respon... Cold exposure is a pervasive stressor in the polar and subpolar regions,exerting both acute and chronic effects on individuals.This environmental factor is known to induce physiological stress,compromise immune response efficacy,and increase susceptibility to various diseases.Chronic cold exposure,characterized by repetitive nonconsecutive exposure to suboptimal temperatures over an extended duration. 展开更多
关键词 ACUTE exposure SUSCEPTIBILITY
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Electroacupuncture targeting the immune system to alleviate sepsis
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作者 Mengyue Fang Yuye Lan +6 位作者 Man Li Chennan Li bin xu Yan Ma Sulukkana Noiprasert Xianghong Jing Lingling Yu 《Acupuncture and Herbal Medicine》 2024年第1期56-67,共12页
Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates.However,options for sepsis are still limited to general treatment in intensive care units(ICUs),and effective therapies that i... Sepsis is a life-threatening inflammatory syndrome with high morbidity and mortality rates.However,options for sepsis are still limited to general treatment in intensive care units(ICUs),and effective therapies that improve sepsis survival are required.Immune disturbances play a vital role in the pathology of sepsis and are associated with protracted inflammation,susceptibility to infections,and death.Therefore,many investigators have focused on the potential benefits of immunomodulation therapy for sepsis.Electroacupuncture(EA)has been practiced in clinics for many years and has shown advantages in treating infectious diseases.Over the last few decades,our understanding of the efficacy and mechanisms of EA in sepsis has undergone considerable developments.We searched the literature regarding“CNKI,Wan Fang Data,VIP Database,PubMed,and Ingenta Connect”from 2010 to 2023,using the keywords“sepsis”“septic”and“electroacupuncture”and 336 sources were searched.Finally,we included 82 studies that targeted the immune system to determine EA’s anti-inflammatory and immunomodulatory effects on sepsis.In this review,we found that EA has clinical benefits in relieving septic inflammation,improving immune function,and attenuating related multi-organ injury through several mechanisms,such as activation of the cholinergic anti-inflammatory pathway(CAP),vagaladrenal axis,inhibition of the nuclear factor Kappa-B(NF-κB)signaling pathway,signal transducers and activators of transcription(STAT)signaling pathway,and improvement of immune cell function.Therefore,EA may be a promising complementary therapy for sepsis treatment.We also expect these data will contribute to further studies on EA in sepsis. 展开更多
关键词 Cholinergic anti-inflammatory pathway ELECTROACUPUNCTURE Nuclear factor Kappa-B SEPSIS Signal transducers and activators of transcription Vagal-adrenal axis
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Gut-targeted therapies for type 2 diabetes mellitus: A review
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作者 Tian-Cheng xu Yun Liu +1 位作者 Zhi Yu bin xu 《World Journal of Clinical Cases》 SCIE 2024年第1期1-8,共8页
Type 2 diabetes mellitus(T2DM)is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance.The global prevalence of T2DM has reached epidemic proportions,affecting approximately 463 million ad... Type 2 diabetes mellitus(T2DM)is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance.The global prevalence of T2DM has reached epidemic proportions,affecting approximately 463 million adults worldwide in 2019.Current treatments for T2DM include lifestyle modifications,oral antidiabetic agents,and insulin therapy.However,these therapies may carry side effects and fail to achieve optimal glycemic control in some patients.Therefore,there is a growing interest in the role of gut microbiota and more gut-targeted therapies in the management of T2DM.The gut microbiota,which refers to the community of microorganisms that inhabit the human gut,has been shown to play a crucial role in the regulation of glucose metabolism and insulin sensitivity.Alterations in gut microbiota composition and diversity have been observed in T2DM patients,with a reduction in beneficial bacteria and an increase in pathogenic bacteria.This dysbiosis may contribute to the pathogenesis of the disease by promoting inflammation and impairing gut barrier function.Several gut-targeted therapies have been developed to modulate the gut microbiota and improve glycemic control in T2DM.One potential approach is the use of probio-tics,which are live microorganisms that confer health benefits to the host when administered in adequate amounts.Several randomized controlled trials have demonstrated that certain probiotics,such as Lactobacillus and Bifidobacterium species,can improve glycemic control and insulin sensitivity in T2DM patients.Mechanisms may include the production of short-chain fatty acids,the improvement of gut barrier function,and the reduction of inflammation.Another gut-targeted therapy is fecal microbiota transplantation(FMT),which involves the transfer of fecal material from a healthy donor to a recipient.FMT has been used successfully in the treatment of Clostridioides difficile infection and is now being investigated as a potential therapy for T2DM.A recent randomized controlled trial showed that FMT from lean donors improved glucose metabolism and insulin sensitivity in T2DM patients with obesity.However,FMT carries potential risks,including transmission of infectious agents and alterations in the recipient's gut microbiota that may be undesirable.In addition to probiotics and FMT,other gut-targeted therapies are being investigated for the management of T2DM,such as prebiotics,synbiotics,and postbiotics.Prebiotics are dietary fibers that promote the growth of beneficial gut bacteria,while synbiotics combine probiotics and prebiotics.Postbiotics refer to the metabolic products of probiotics that may have beneficial effects on the host.The NIH SPARC program,or the Stimulating Peripheral Activity to Relieve Conditions,is a research initiative aimed at developing new therapies for a variety of health conditions,including T2DM.The SPARC program focuses on using electrical stimulation to activate peripheral nerves and organs,in order to regulate glucose levels in the body.The goal of this approach is to develop targeted,non-invasive therapies that can help patients better manage their diabetes.One promising area of research within the SPARC program is the use of electrical stimulation to activate the vagus nerve,which plays an important role in regulating glucose metabolism.Studies have shown that vagus nerve stimulation can improve insulin sensitivity and lower blood glucose levels in patients with T2DM.Gut-targeted therapies,such as probiotics and FMT,have shown potential for improving glycemic control and insulin sensitivity in T2DM patients.However,further research is needed to determine the optimal dose,duration,and safety of these therapies. 展开更多
关键词 Type 2 diabetes mellitus GASTROENTEROLOGY BACTERIA Implanted device
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MRI与关节镜对痛风性膝关节炎的诊断比较 被引量:22
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作者 袁伶俐 徐斌 +2 位作者 张跃 王高远 徐文弟 《中国现代医学杂志》 CAS 2018年第17期109-114,共6页
目的比较膝关节痛风性关节炎MRI诊断与关节镜诊断的优缺点。方法选取30例患者行MRI与膝关节镜检查,并经病理学检查证实为痛风性关节炎,对MRI与关节镜诊断治疗痛风性关节炎的优缺点进行比较分析。结果 MRI与关节镜膝对痛风性膝关节炎关... 目的比较膝关节痛风性关节炎MRI诊断与关节镜诊断的优缺点。方法选取30例患者行MRI与膝关节镜检查,并经病理学检查证实为痛风性关节炎,对MRI与关节镜诊断治疗痛风性关节炎的优缺点进行比较分析。结果 MRI与关节镜膝对痛风性膝关节炎关节腔内相关病情诊断无差异(P>0.05),膝关节周围病情的诊断MRI优于关节镜。结论 MRI与关节镜膝对痛风性膝关节炎关节腔内相关病情诊断无差异,而膝关节腔外病情的诊断MRI优于关节镜。 展开更多
关键词 痛风 膝关节痛风性关节炎 痛风结节 痛风石 关节镜
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Illegal Logging and Related Trade: Who Combat It as Legal Subjects? 被引量:2
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作者 Jing Qian bin xu +1 位作者 Hongqiang Yang Ying Nie 《Open Journal of Forestry》 2016年第1期39-49,共11页
Issue on illegal logging and related trade is a hot topic for the international community. It has brought the negative effects to the sustainable development on global society, economy and ecology, which is also one o... Issue on illegal logging and related trade is a hot topic for the international community. It has brought the negative effects to the sustainable development on global society, economy and ecology, which is also one of the main objectives of international cooperation to combat with. At present, subjects of international law play a decisive role in combating illegal logging and related trade. The subjects of international law generally refer to states, intergovernmental organizations (IGOs) and part of non-governmental organizations (NGOs), which can have an independent international legal personality, enjoy rights and assume obligations of international law. As a responsible big country of the international community and state member of intergovernmental organizations and international treaties of forest resources protection, China ought to fully perform the obligations of international law. In face of illegal logging and related trade around the world, China should rationally tackle with it, resolutely crack down on it, and finally choose the sustainable development strategy based on rule of law. 展开更多
关键词 Illegal Logging and Related Trade Legal Subjects Rule of Law Sustainable Forestry Development
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急性冠脉综合征患者原研与“带量采购”阿托伐他汀钙片疗效和安全性的回顾性比较 被引量:3
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作者 彭倩雯 徐斌 张伟霞 《药物流行病学杂志》 CAS 2023年第4期361-366,共6页
目的比较国产带量采购和原研阿托伐他汀钙片治疗急性冠脉综合征患者的疗效和安全性。方法回顾性分析2020年4月—2021年3月上海交通大学医学院附属瑞金医院心内科使用原研(辉瑞制药有限公司,立普妥)和带量采购中标(乐普制药科技有限公司... 目的比较国产带量采购和原研阿托伐他汀钙片治疗急性冠脉综合征患者的疗效和安全性。方法回顾性分析2020年4月—2021年3月上海交通大学医学院附属瑞金医院心内科使用原研(辉瑞制药有限公司,立普妥)和带量采购中标(乐普制药科技有限公司,优力平)阿托伐他汀钙片的急性冠脉综合征患者资料,以用药4~6周后低密度脂蛋白胆固醇(LDL-C)达标率、血脂水平变化以及不良事件为评价指标。结果纳入73例有效患者,其中立普妥组37例,优力平组36例,立普妥组患者LDL-C达标率为43.2%,优力平组LDL-C达标率为50.0%,差异无统计学意义(P>0.05)。两组患者治疗后各项血脂水平均较治疗前明显改善(P<0.05);且两组间各项指标的变化幅度绝对值和百分比差异无统计学意义(P>0.05)。两组药品不良事件也未见明显差异(P>0.05)。结论我院使用带量采购中标和原研的阿托伐他汀钙片治疗急性冠脉综合征的疗效和安全性具有一致性。 展开更多
关键词 阿托伐他汀钙片 急性冠脉综合征 队列研究 真实世界研究 带量采购
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Studies on Ecological Monitoring of Plant Community and Plant Diversity in Shenzhen, Southern China
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作者 Yuyuan Huang Xinfan Yu +31 位作者 Hong Liang Zhiming Yang Haiyang Wen Zhen Ye Yunhe Lu Ruoyu Wei Lijun Yang Song Ma Kangsai Zhao Fan Wang Zhijie Chen Huina Yang Chengxi Jiang bin xu Weimin Wang Wang xu Zhu Ming Shizhen Lin Hao Liu Hualiang Luo Suni Deng Lijuan Huang Yanjun Lei Xiaoli Wan Yahe Li Wanmin Zhou Shun Zhao Zhenliang Duan Dongyao Liao Xiaobo Qiu Haoqun Huang Linlin Jiang 《Open Journal of Forestry》 2021年第4期352-380,共29页
From Jan</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> 2013 to Nov</span><span style="font-family:Verdana;">.<... From Jan</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> 2013 to Nov</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> 2018, we carried out the investigation on vegetation studies in the ecological monitoring programs, Shenzhen</span><span style="font-family:Verdana;"> and</span><span style="font-family:""><span style="font-family:Verdana;"> totally researched 170 plant communities of mountain areas etc., </span><span style="font-family:Verdana;">few areas of street regions and parks etc., for communities’ structural characteristics and plant diversity. We comparatively analyzed natural forests, semi-natural forest and artificial forest composition and structural characters and family, genus and species diversity level and the main affected factors. We also researched and analyzed these communities’ structural characteristics and pant diversity, </span><span style="font-family:Verdana;">comparatively analyzed natural forests, semi-natural forest and artificial forest composition and structural characters and family, genus and species diversity level, the main affected factors;researched and analyzed the relationship between plant community structure characteristics with the absorbing ability to PM</span><sub><span style="font-family:Verdana;">2.5</span></sub><span style="font-family:Verdana;"> pollutants. The result showed that the structure and plant diversity of natural </span><span style="font-family:Verdana;">forest </span></span><span style="font-family:Verdana;">were </span><span style="font-family:Verdana;">obviously better than</span><span style="font-family:Verdana;"> artificial disturbed forest or artificial forest, the semi-natural forest w</span><span style="font-family:Verdana;">as</span><span style="font-family:Verdana;"> the middle level of the forests, In the indices of height, DBH, coverage and crow width etc. of tree layer, natural forests and semi-natural forests were obvious higher than that of artificial disturbed forest or artificial forest;in some forests of artificial disturbed forest or artificial forest, though their richness indices of family and genus were a slightly higher, but this contribution was majorly due to herb layer plants, and some shrub layer plants. Analyz</span><span style="font-family:Verdana;">ing</span><span style="font-family:Verdana;"> three kinds of communities, the number of tree layer species of natural forest was</span><span style="font-family:Verdana;"> the </span><span style="font-family:""><span style="font-family:Verdana;">largest, and their every </span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;">-diversity index value was </span></span><span style="font-family:Verdana;">the </span><span style="font-family:Verdana;">highest;these characteristics values of semi-natural forest were second, artificial disturbed forests or artificial forests were </span><span style="font-family:Verdana;">the </span><span style="font-family:""><span style="font-family:Verdana;">lowest;in shrub layer, and herb layer, few </span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;">-diversity indices of artificial disturbed forest or artificial forest were </span><span style="font-family:Verdana;">a slightly higher than that of some natural forests, but the integral values of the diversity indices of natural forest and semi-natural forest were obvious</span></span><span style="font-family:Verdana;">ly</span><span style="font-family:Verdana;"> higher than the former. The research showed that in the artificial disturbed forest or artificial forest, because there have some little scale clearing area</span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;">, so some pioneer plant species could enter the community and formed a temporarily </span><span style="font-family:Verdana;">increase of species diversity, however</span></span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> these species major </span><span style="font-family:Verdana;">were</span><span style="font-family:Verdana;"> some shrub and herb plants;but tree layer possessed obvious</span><span style="font-family:Verdana;">ly</span><span style="font-family:Verdana;"> more, even surpass</span><span style="font-family:Verdana;">ed</span><span style="font-family:Verdana;"> several ten times biomass than shrub and herb layers</span><span style="font-family:Verdana;">.</span><span style="font-family:Verdana;"> Therefore</span><span style="font-family:Verdana;">,</span><span style="font-family:Verdana;"> the respect</span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> of maintain ecosystem stability and other</span><span style="font-family:Verdana;"> ecological efficient have </span><span style="font-family:Verdana;">major and dominated position and so on;and then this community can </span></span><span style="font-family:Verdana;">be </span><span style="font-family:Verdana;">natural recovery and succession, those forementioned new entire plants shall withdraw from the community and are replaced by the original plants of the community;but this process has already caused the ecological efficient loss and ecosystem unstable. Above research results are better evidence and theory reference to the argument problems on that </span><span style="font-family:Verdana;">are</span><span style="font-family:""><span style="font-family:Verdana;"> natural forest and natural restoration forest biodiversity higher? or is artificial forest biodiversity higher? and or is more artificial disturbed forest higher?</span><span style="font-family:Verdana;"> Our researches showed that used random investigation method set quadrats, and combined typical investigation method, the structural indices in the all layer of community and all diversity indices of tree, shrub and herb layers and the integral values </span></span><span style="font-family:Verdana;">were</span><span style="font-family:""><span style="font-family:Verdana;"> similar, same or usually these indices in the community which set 600 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;">, 800 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> total quatrat area were higher (</span><i><span style="font-family:Verdana;">α</span></i><span style="font-family:Verdana;">-diversity) than that of more than 3000 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;">, 4000 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> or 7000 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;">, even more than 17,000 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> total qua</span></span><span style="font-family:Verdana;">d</span><span style="font-family:Verdana;">rat area of communities. These lot</span><span style="font-family:Verdana;">s</span><span style="font-family:""><span style="font-family:Verdana;"> of researches further proved that according to minimum area method for vegetation survey, in subtropical region, using random investigation method combined with typical investigation set 400 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> or 400 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> - 500 m</span><sup><span style="font-family:Verdana;">2</span></sup><span style="font-family:Verdana;"> total qua</span></span><span style="font-family:Verdana;">d</span><span style="font-family:""><span 展开更多
关键词 SHENZHEN VEGETATION COMMUNITY Structure DIVERSITY PM2.5 Ecological Monitoring Natural Forest Artificial Forest
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Perineal Electric Burn Reconstruction Using Modified Thoraco-Umbilical Flap
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作者 bin xu Jinlong Wang 《International Journal of Clinical Medicine》 2016年第7期461-463,共4页
Perineal reconstruction is an essential component of the overall treatment plan of perineal electric burn, but it is a very difficult and complex job. The modified thoraco-umbilical flap may be a perfect way of repair... Perineal reconstruction is an essential component of the overall treatment plan of perineal electric burn, but it is a very difficult and complex job. The modified thoraco-umbilical flap may be a perfect way of repairing perineal area. It is based on the deep inferior epigastric artery and vein and the superior epigastric artery and vein, which look like the “reverse TRAM flap”. The large flap could be fashioned into a perfect perineal area without the need for free flap. It left a satisfactory donor scar, and it avoided the need to change the patient’s position during the operation. Four cases were reconstructed by modified thoraco-umbilical flap after perineal electric burn, and all of them were satisfied with the results. The modified thoraco-umbilical flap has been emerged as a very useful reconstructive tool and is particularly valuable in reconstruction of the perineal electric burn. 展开更多
关键词 Perineal Electric Burn The Modified Thoraco-Umbilical Flap
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铜和金硫代硫酸盐在活性炭上的吸附机理
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作者 谢锋 陈俊南 +2 位作者 张小贞 徐斌 王伟 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2023年第10期3210-3221,I0001,共13页
研究活性炭对铜和金硫代硫酸盐的吸附机理。铜和金硫代硫酸盐在活性炭上的吸附动力学均符合准二级动力学模型。活性炭对铜硫代硫酸盐的吸附等温线符合Freundlich模型,而对金硫代硫酸盐的吸附等温线符合Langmuir模型。负载活性炭的键合... 研究活性炭对铜和金硫代硫酸盐的吸附机理。铜和金硫代硫酸盐在活性炭上的吸附动力学均符合准二级动力学模型。活性炭对铜硫代硫酸盐的吸附等温线符合Freundlich模型,而对金硫代硫酸盐的吸附等温线符合Langmuir模型。负载活性炭的键合特性分析表明,活性炭对铜和金的吸附机理不同。在实验条件下,活性炭对铜的吸附量达到79.04 mg/g,比金的吸附量高出约2个数量级。这意味着由于金的吸附量低以及铜和硫代硫酸盐的竞争吸附,用活性炭从硫代硫酸盐浸出液中回收金将面临很大的挑战。 展开更多
关键词 活性炭 吸附 硫代硫酸盐
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