A Tabletop Nano-CT Image Noise Reduction Network Based on 3-Dimensional Axial Attention Mechanism

Nano-computed tomography(Nano-CT)is an emerging,high-resolution imaging technique.However,due to their low-light properties,tabletop Nano-CT has to be scanned under long exposure conditions,which the scanning process is time-consuming.For 3D reconstruction data,this paper proposed a lightweight 3D noise reduction method for desktop-level Nano-CT called AAD-ResNet(Axial Attention DeNoise ResNet).The network is framed by theU-net structure.The encoder and decoder are incorporated with the proposed 3D axial attention mechanism and residual dense block.Each layer of the residual dense block can directly access the features of the previous layer,which reduces the redundancy of parameters and improves the efficiency of network training.The 3D axial attention mechanism enhances the correlation between 3D information in the training process and captures the long-distance dependence.It can improve the noise reduction effect and avoid the loss of image structure details.Experimental results show that the network can effectively improve the image quality of a 0.1-s exposure scan to a level close to a 3-s exposure,significantly shortening the sample scanning time.

Data augmentation method for insulators based on Cycle-GAN

Data augmentation is an important task of using existing data to expand data sets.Using generative countermeasure network technology to realize data augmentation has the advantages of high-quality generated samples,simple training,and fewer restrictions on the number of generated samples.However,in the field of transmission line insulator images,the freely synthesized samples are prone to produce fuzzy backgrounds and disordered samples of the main insulator features.To solve the above problems,this paper uses the cycle generative adversarial network(Cycle-GAN)used for domain conversion in the generation countermeasure network as the initial framework and uses the self-attention mechanism and channel attention mechanism to assist the conversion to realize the mutual conversion of different insulator samples.The attention module with prior knowledge is used to build the generation countermeasure network,and the generative adversarial network(GAN)model with local controllable generation is built to realize the directional generation of insulator belt defect samples.The experimental results show that the samples obtained by this method are improved in a number of quality indicators,and the quality effect of the samples obtained is excellent,which has a reference value for the data expansion of insulator images.

Theoretical Models on Interfacial Thermal Conductance of Nanoscale Solid Interfaces in Chips:A Mini Review

With the rapid increase in power density of electronic devices,thermal management has become urgent for the electronics industry.Controlling temperature in the back-end-of-line is crucial for maintaining the reliability of integrated circuits,where many atomic-scale interfaces exist.The theoretical models of interface thermal conductance not only accurately predict the values but also help to analyze the underlying mechanism.This review picks up and introduces some representative theoretical models considering interfacial roughness,elastic and inelastic processes,and electron–phonon couplings,etc.Moreover,the limitations and problems of these models are also discussed.

Investigation of the Film Formation in Dynamic Air Spray Painting

To accurately predict the film thickness distribution during dynamic spraying performed with air guns and support accordingly the development of intelligent spray painting,the spray problem was analyzed numerically.In particular,the Eulerian-Eulerian approach was employed to calculate the paint atomization and film deposition process.Different spray heights,spray angles,spray gun movement speeds,spray trajectory curvature radii,and air pressure values were considered.Numerical simulation results indicate that the angle of spray painting significantly affects the velocity of droplets near the spray surface.With an increase in the spraying angle,spraying height and spray gun movement speed,the maximum film thickness decreases to varying degrees,and the uniformity of the film thickness also continuously worsens.When the spray gun moves along an arc trajectory,at smaller arc radii,the film thickness on the inside of the arc is slightly greater than that on the outside,but the impact on the maximum film thickness is minimal.Increasing air pressure expands the coating coverage area,results in finer atomization of paint droplets,and leads to a thinner and a more uniform paint film.However,if the pressure is too high,it can cause paint splattering.Using the orthogonal experimental method,multiple sets of simulation calculations were conducted,and the combined effects of spraying height,spray angle,and spray gun movement speed on the film thickness distribution were comprehensively analyzed to determine optimal configurations.Finally,the reliability of the numerical simulations was validated through dynamic spray painting experiments.

Establishment and expression of recombinant human glial cell linederived neurotrophic factor and TNF α receptor in human neural stem cells

Objective:To investigate the interference and expression of human glial cell line-derived neurotrophic factor(hCDNF) and soluble TNF alpha(sTMFRⅠ) receptor genes in neural stem cells and to evaluate the roles of these proteins in the genetic treatment of spinal cord injury.Methods:Full-length of GDNF cDNA(538 bp) and sTMFRⅠcDNA(504 bp) were inserted into the early 1 region of adenovirus genomic DNA respectively and were immediated by the human cytomegalovirus(gene promoter/enhancer). These adenoviruses were propagated in HEK293 cells via homologous recombination for 7-10 days in vivo,then they were used to infect human neural stem ceils.The infection and expression of gene were tested under immunofluorescence.ELISA and Westem-blot after 48 hours.Results:Almost all the cultured cells showed the nestin immunofluorescence positive staining,which was the characteristics of neural stem cell.A great quantity of EGFP and KFP were observed in neural stem cells,which indicated the expression of GDNF and sTMFRⅠ.After transfection of GDNF and sTMFRⅠgenes,many neural stem cells show GFAP and tubulin immunofluorescence positive staining,which meant that most neural stem cells differentiated into neuron at that condition.Conclusions:The infective efficiency of adenovirus is greatly acceptable to neural stem cell,thus adenovirus provide a useful vector for exogenous GDNF and sTMFRⅠgenes expressing in neural stem cells,which is useful for differentiation of neural stem cell.

Geospatial-Based Analysis of Balance in Elementary Education—Taking Elementary Schools in Changsha Five Core Districts as Examples

The balanced development of the elementary education sector has been a long goal pursued by the education departments of various places, and is also an outcome expected by the people. Based on a study of the equilibrium of the spatial distribution of the capacity saturation models of all the primary schools in Changsha’s (China) five core districts, the results show that the overall geographical distribution of the primary schools in Changsha is relatively balanced, based on the natural characteristics of Changsha, such as human geography, and the moderate gradient between the central urban area and the primary schools in the suburbs and outer suburbs. Then the Theil index model was introduced, and the results of the model analysis show that the differences between elementary schools in Changsha urban area are relatively small, and the main differences originate from between districts rather than within districts, and subtle differences among regions mainly reflect in the teacher strength.

Railway Engineering Experimental Teaching Research Based on the Combination of Field Experiment and Virtual Reality(VR)Technology——Taking Central South University as an Example

At present,rail transit is developing rapidly in the world,and this means new and changing requirements for the training of talents in railway engineering experiments.Given the current problems of limited laboratory/field instruments for railway engineering experimentsand the safety/administrative difficulties of going to the frontline of railway lines to teach railway engineering experiemnts in the field,the Department of Railway Engineering of Central South University tried to introduce virtual reality(VR)technology to teach students experiments in the field of railway engineering.Through the virtualized experimental methods,students can carry out railway engineering experiments such as;vehicle wheel pair off-axis experiments,track geometry and position detection,etc.by immersive means.It was observed that after performing virtual simulation experiments,students appeared conversant in subsequent field experiments.Thus,VR greatly improves the teaching efficiency of railway engineering experiments.

Clinical characteristics and outcome of autoimmune pancreatitis based on serum immunoglobulin G4 level:A single-center,retrospective cohort study

BACKGROUND Autoimmune pancreatitis(AIP)has been linked with elevated immunoglobulin(Ig)G4 levels.The characteristics and outcomes of AIP based on serum markers have not been fully evaluated.AIM To compare clinical features,treatment efficacy,and outcome of AIP based on serum IgG4 levels and analyze predictors of relapse.METHODS A total of 213 patients with AIP were consecutively reviewed in our hospital from 2006 to 2021.According to the serum IgG4 level,all patients were divided into two groups,the abnormal group(n=148)with a high level of IgG4[>2×upper limit of normal(ULN)]and the normal group(n=65).The t-test or Mann-Whitney U test was used to compare continuous variables.Categorical parameters were compared by theχ^(2) test or Fisher’s exact test.Kaplan-Meier curves Zhou GZ et al.Clinical characteristics and outcome of AIP WJG https://www.wjgnet.com 5126 September 21,2023 Volume 29 Issue 35 and log-rank tests were established to assess the cumulative relapse rates.Univariate and multivariate analyses were used to investigate potential risk factors of AIP relapse.RESULTS Compared with the normal group,the abnormal group had a higher average male age(60.3±10.4 vs 56.5±12.9 years,P=0.047);higher level of serum total protein(72.5±7.9 g/L vs 67.2±7.5 g/L,P<0.001),IgG4(1420.5±1110.9 mg/dL vs 252.7±106.6 mg/dL,P<0.001),and IgE(635.6±958.1 IU/mL vs 231.7±352.5 IU/mL,P=0.002);and a lower level of serum complement C3(100.6±36.2 mg/dL vs 119.0±45.7 mg/dL,P=0.050).In addition,a lower number of cases with abnormal pancreatic duct and pancreatic atrophy(23.6%vs 37.9%,P=0.045;1.6%vs 8.6%,P=0.020,respectively)and a higher rate of relapse(17.6%vs 6.2%,P=0.030)were seen in the abnormal group.Multivariate analyses revealed that serum IgG4[(>2×ULN),hazard ratio(HR):3.583;95%confidence interval(CI):1.218–10.545;P=0.020]and IgA(>1×ULN;HR:5.908;95%CI:1.199–29.120;P=0.029)and age>55 years(HR:2.383;95%CI:1.056–5.378;P=0.036)were independent risk factors of relapse.CONCLUSION AIP patients with high IgG4 levels have clinical features including a more active immune system and higher relapse rate.Several factors,such as IgG4 and IgA,are associated with relapse.

Influence of Spray Gun Position and Orientation on Liquid Film Development along a Cylindrical Surface

A method combining computationalfluid dynamics(CFD)and an analytical approach is proposed to develop a prediction model for the variable thickness of the spray-induced liquidfilm along the surface of a cylindrical workpiece.The numerical method relies on an Eulerian-Eulerian technique.Different cylinder diameters and positions and inclinations of the spray gun are considered and useful correlations for the thickness of the liquidfilm and its distribution are determined using various datafitting algorithms.Finally,the reliability of the pro-posed method is verified by means of experimental tests where the robot posture is changed.The provided cor-relation are intended to support the optimization of spray-based coating applications.

Asymmetric Loss Based on Image Properties for Deep Learning-Based Image Restoration

Deep learning techniques have significantly improved image restoration tasks in recent years.As a crucial compo-nent of deep learning,the loss function plays a key role in network optimization and performance enhancement.However,the currently prevalent loss functions assign equal weight to each pixel point during loss calculation,which hampers the ability to reflect the roles of different pixel points and fails to exploit the image’s characteristics fully.To address this issue,this study proposes an asymmetric loss function based on the image and data characteristics of the image recovery task.This novel loss function can adjust the weight of the reconstruction loss based on the grey value of different pixel points,thereby effectively optimizing the network training by differentially utilizing the grey information from the original image.Specifically,we calculate a weight factor for each pixel point based on its grey value and combine it with the reconstruction loss to create a new loss function.This ensures that pixel points with smaller grey values receive greater attention,improving network recovery.In order to verify the effectiveness of the proposed asymmetric loss function,we conducted experimental tests in the image super-resolution task.The experimental results show that the model with the introduction of asymmetric loss weights improves all the indexes of the processing results without increasing the training time.In the typical super-resolution network SRCNN,by introducing asymmetric weights,it is possible to improve the peak signal-to-noise ratio(PSNR)by up to about 0.5%,the structural similarity index(SSIM)by up to about 0.3%,and reduce the root-mean-square error(RMSE)by up to about 1.7%with essentially no increase in training time.In addition,we also further tested the performance of the proposed method in the denoising task to verify the potential applicability of the method in the image restoration task.

基于立体摄影技术的三维照相系统获取畸形面部影像的精确性研究

目的探究基于立体摄影技术的三维照相系统获取畸形面部影像的精确性及其影响因素。方法采用基于立体摄影技术的三维照相系统采集45个面部畸形的蜡制脸模的表面数据,测量19个面部软组织特征线距,以三坐标仪采集测量结果作为标准值,分析三维照相系统获取畸形面部影像的精确性,以及不同畸形形态与面部区域对测量结果精确性的影响。结果三维照相系统获取的特征线距的测量值与标准值具有统计学差异(P<0.001)。凸起畸形对三维照相系统的测量误差有显著性影响(P<0.05),裂隙畸形对三维照相系统的测量误差无显著性影响(P>0.05)。不同面部区域的三维照相系统测量误差有统计学差异(P<0.05)。畸形形态对三维照相系统测量偏大百分比无显著性影响(P>0.05)。中间区域与面部两侧区域的测量偏大百分比具有统计学差异(P<0.05),左侧区域与右侧区域的测量偏大百分比无统计学差异(P>0.05)。结论对畸形面部影像的分析,基于立体摄影技术的三维照相系统测量正畸临床常规线性项目的精确性受畸形形态与面部区域的影响,但误差在临床可接受范围内。

新型系线式磁控胶囊内镜对猪食管和胃检查的可行性和安全性分析

背景现有的磁控胶囊胃镜存在诸多不足,如分辨率和拍摄帧率低,通过食管时的速度不可控而无法全面观察食管,且存在胶囊内镜滞留的风险.新型系线式磁控胶囊内镜可实现高帧率、高分辨率,能全面观察食管且无胶囊滞留风险.目的通过动物实验验证一种新型系线式磁控胶囊内镜对食管和胃检查的可行性和安全性.方法对3只巴马小型猪先后行磁控胶囊内镜和传统胃镜检查,记录食管和胃的检查时间,评估磁控胶囊内镜在食管和胃的各个部位(食管上、中、下段、齿状线、贲门、胃底、胃体、胃角、胃窦、幽门)的可控性和粘膜可视度.分析实验动物检查前、后的血常规和生化指标,观察实验过程中的不良反应.结果与传统胃镜相比,磁控胶囊内镜在食管检查时间上无显著差异(104.67 s±7.02 s vs 88.33 s±3.51 s,P=0.093),对胃的检查耗时较长(25.67 min±5.69 min vs 6.00 min±1.00 min,P=0.019).磁控胶囊内镜的可控性和粘膜可视度在食管、齿状线、胃体、胃窦及幽门处较好,在贲门和胃底处稍差.实验动物无明显不良反应发生.结论这一新型的系线式磁控胶囊内镜对猪食管和胃的检查具有良好的可行性和安全性.

上消化道胶囊内镜现状及研究进展

胶囊内镜是一种安全、无创、人群接受度高的消化道疾病诊断系统,目前已广泛用于小肠疾病的诊断.由于食管通过速度快,胃腔空间大,导致胶囊内镜在上消化道中的应用面临巨大挑战.目前随着磁导航技术、系线胶囊技术等工程技术的发展,胶囊内镜逐步拓展了在上消化道疾病诊断中的应用.有多款上消化道胶囊内镜已应用于临床,同时有更多的胶囊内镜新兴技术正处于研发阶段,为改善胶囊内镜在上消化道疾病诊断中的作用提供了新的希望,本文就用于上消化道的胶囊内镜现状及研究进展做一综述.

Prevalence and Determinants of High-risk HPV Infection among 11549 Women from an Opportunistic Screening in Hubei Province

High-risk human papillomavirus (hrHPV) infection plays an important role in the development of cervical intraepithelial neoplasia and cervical cancer.A total of 11 549 women were enrolled from the Maternal and Child Health Hospital of Hubei Province.Each participant accepted hrHPV testing and completed a self^administered questionnaire about basic information and potential risk factors.The univariable and multivariable logistic regression model was used to explore the associations between variants and hrHPV infection.Our results showed that hrHPV prevalence was 16.09% in Hubei Province,among which,hrHPV was more likely to be positive in women aged 51 years or above (OR=1.65,95% CI:1.28-2.14),and in women who had symptoms of bleeding after intercourse (OR=1.32,95% CI:1.17-1.50),had first sexual intercourse at the age of 18 years or below (OR=1.33,95% CI:1.07-1.64),had at least three male sexual partners (OR=2.50,95% CI:2.07-3.03),and who had been diagnosed with sexually transmitted infections (OR=1.50,95% CI:1.12-2.03).Married women (OR=0.66,95% CI:0.55-0.78) and women who frequently used condoms (OR=0.75,95% CI:0.67-0.84) had a relatively lower hrHPV prevalence.This study confirms that hrHPV infection was associated with age,marital status,symptoms of intercourse bleeding,history of sexually transmitted infections,and sex-related behaviors.Above all,this study provides a baseline database prior to obtaining vaccinations for dynamic tracking of the changes in hrHPV prevalence.

Application of an indirect immunofluorescent staining method for detection of Salmonella enteritidis in paraffin slices and antigen location in infected duck tissues

AIM： To detect Salmonella enteritidis （S. enteritidis） in paraffin slices and antigen location in infected duck tissues. METHODS： The rabbits were immunized with purified bacillus to obtain S. enteritidis-specific antibody, which were then extracted by the caprylic-ammonium sulphate method, purified through High-Q columns. An indirect immuno-fluorescent staining method （IFA） was established to detect the S. enteritidis antigen in paraffin slices. Detected S. enteritidis in each organ tissue of ducklings experimentally infected with S. enteritidis. RESULTS： The gland of Garder, heart, kidney, spleen, liver, brain, ileum, jejunum, bursa of Fabricius from S. enteritidis experimentally infected ducklings were positive or strongly positive, and the S. enteritidis antigen mainly distributed in the infected cell cytoplasm.CONCLUSION： IFA is an intuitionist, sensitive and specific method in detecting S. enteritidis antigen in paraffin wax slices, and it is a good method in diagnosis and antigen location of S. enteritidis. We also conclude that the gland of Garder, heart, kidney, spleen, liver, ileum, jejunum are target organs in S. enteritidis infections of duck, and S. enteritidis is an intracellular parasitic bacterium.

Quantitative studies of the regular distribution pattern for Salmonella enteritidis in the internal organs of mice after oral challenge by a specific real-time polymerase chain reaction

AIM： To identify and understand the regular distribution pattern for Salmonella enteritidis （S. enteritidis） in the internal organs of mice after an oral challenge over a 3 wk period. METHODS： Assays based on the serovar-specific DNA sequence of S. enteritidis from GenBank, and a serovar-specific real-time, fluorescence-based quantitative polymerase chain reaction （FQ-PCR） were developed for the detection of S. enteritidis. We used this assay to detect genomic DNA of S. enteritidis in the blood and the internal organs, including heart, liver, spleen, kidney, pancreas, and gallbladder, from mice after oral challenge at different time points respectively.RESULTS： The results showed that the spleen was positive at 12 h post inoculation （PI）, and the blood was at 14 h PI. The organism was detected in the liver and heart at 16 h PI, the pancreas was positive at 20 h PI, and the final organs to show positive results were the kidney and gallbladder at 22 h PI. The copy number of S. enteritidis DNA in each tissue reached a peak at 24-36 h PI, with the liver and spleen containing high concentrations of S. enteritidis, whereas the blood, heart, kidney, pancreas, and gallbladder had low concentrations. S. enteritidis populations began to decrease and were not detectable at 3 d PI, but were still present up to 12 d PI in the gallbladder, 2 wk for the liver, and 3 wk for the spleen without causing apparent symptoms.CONCLUSION： The results provided significant data for understanding the life cycle of S. enteritidis in the internal organs, and showed that the liver and spleen may be the primary sites for setting itself up as a commensa over a long time after oral challenge. Interestingly, it may be the first time reported that the gallbladder is a site of carriage for S. enteritidis over a 12 d period. This study will help to understand the mechanisms of action of S. enteriCdis infection in vivo.

Fruit and Vegetable Nutrition Value Assessment and Replacement Based on the Principal Component Analysis and Cluster Analysis

Utilizing principal component analysis (PCA) and cluster analysis, the standardization, dimension-reduction and de-correlation of multiple evaluation index system for fruit and vegetable nutrition are performed to assign principal component factor based on cluster analysis of loading matrix and combining with actual meaning and evaluation direction of index categories. To evaluate the richness of its nutrition according to the score of nutrition of fruit and vegetable, finally equivalent replacement suggestions are given in different seasons of vegetables & fruits according to the result of clustering. Studies show that principal component cluster method can not only carry on the reasonable classification of multivariate data effectively, but also make reasonable evaluation on the sample object, and provide powerful basis for evaluation of fruits and vegetables’ nutrition.

Association between uveitis and psoriatic disease: a systematic review and Meta-analysis based on the evidence from cohort studies

AIM: To conduct a systematic review and Meta-analysis to examine the association between uveitis and psoriatic disease, and to evaluate whether one condition predisposes individuals to the other. METHODS: We performed a comprehensive search of Pub Med and EMBASE to identify cohort studies examining the association between uveitis and psoriatic disease [psoriasis and/or psoriatic arthritis(Ps A)]. We used a random-effects model to calculate the pooled relative risks(RRs) adjusted for confounders, along with the 95% confidence intervals(CIs). RESULTS: This Meta-analysis included a total of 6 studies and a maximum of 80 178 648 participants. Compared with non-psoriatic controls, uveitis risk was significantly elevated in patients with psoriasis(RR=1.49;95%CI: 1.08-2.07), and Ps A(RR=3.16;95%CI: 2.16-4.63). Furthermore, pre-existing uveitis was associated with a significantly increased risk of psoriasis(RR=1.62;95%CI: 1.44-1.83), and Ps A(RR=4.44;95%CI: 3.52-5.60).CONCLUSION: The results of this systematic review and Meta-analysis suggest an overall positive bidirectional association between uveitis and psoriatic disease(psoriasis and Ps A), warranting increased awareness among clinicians involved in the management of these two conditions.Therefore, there remains a need for more detailed studies of the possible common pathogenesis of psoriatic disease and uveitis.

Agronomic cultivation measures on productivity of oilseed flax:A review

Oilseed flax is one of the most important oil crops in China.With the improvement of people's living standards and the deepening knowledge of the nutritional value of oilseed flax,the demand and economic value of oilseed flax are increasing,and the cultivated area in China is expanding.However,the grain yield of oilseed flax is lower than other oil crops.It varies significantly from year to year,combined with a lower degree of mechanization,which has greatly limited the healthy development of the flax industry.Some of the effects of agronomic measures on productivity and water use efficiency of oilseed flax are reviewed in this paper.The major agronomic strategies for the productivity of oilseed flax were presented based on fertilization,plant density,irrigation,cropping pattern and weed control.Future research should investigate the effect of silicon and potassium fertilizers on the mechanism of lodging resistance of oilseed flax,the effects of diversified cropping systems(strip intercropping and crop rotation)on high and stable productivity and efficient utilization of resources.

Effect of anti-VEGF treatment on nonperfusion areas in ischemic retinopathy

In recent years,retinal ischemia such as that which occurs in diabetic retinopathy(DR)and retinal vein occlusion(RVO)has become a hotspot of ischemic retinopathy research.High levels of vascular endothelial growth factor(VEGF)are recognized as a major cause of macular edema(ME)in DR and RVO.High concentrations of VEGF in the vitreous can lead to serious retinal ischemia and hypoxia and form retinal nonperfusion areas(NPAs).Different levels of retinal ischemia can represent disease severity and progression.Anti-VEGF therapy as the first-line treatment for ME has been found to be effective in improving vision,but there are still disputes about whether anti-VEGF therapy could improve retinal ischemia and achieve reper fusion of previously developed retinal NPAs.Here,we review and summarize studies of the effects of anti-VEGF drugs on retinal ischemia,especially NPAs.