Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene.The ephrins and EPH-related receptors comprise the largest subfamily of receptor proteintyrosine kinases which play an indispensable role in normal gr...Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene.The ephrins and EPH-related receptors comprise the largest subfamily of receptor proteintyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors.The role of EFNA1 in tumorigenesis and development is complex and depends on the cell type and microenvironment which in turn affect the expression of EFNA1.This article reviews the expression,prognostic value,regulation and clinical significance of EFNA1 in gastrointestinal tumors.展开更多
基金Supported by the Natural Science Foundation of China,No.81972801the Guangdong Basic and Applied Basic Research Foundation,No.2019A1515011873+1 种基金the Medical Project of Science and Technology Planning of Shantou,No.200605115266724the 2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant,No.2020LKSFG01B.
文摘Ephrin-A1 is a protein that in humans is encoded by the EFNA1 gene.The ephrins and EPH-related receptors comprise the largest subfamily of receptor proteintyrosine kinases which play an indispensable role in normal growth and development or in the pathophysiology of various tumors.The role of EFNA1 in tumorigenesis and development is complex and depends on the cell type and microenvironment which in turn affect the expression of EFNA1.This article reviews the expression,prognostic value,regulation and clinical significance of EFNA1 in gastrointestinal tumors.
