Diwu Yanggan Modulates the Wnt/β-catenin Pathway and Inhibits Liver Carcinogenesis Signaling in 2-AAF/PH Model Rats

The activation of the Wnt/β-catenin signaling pathway in oval cells after liver injury is implicated in hepatocarcinogenesis.Diwu Yanggan capsule is a Chinese herbal medicine that has been used for treating liver disorder.The present study aimed to examine the mechanism by which Diwu Yanggan inhibits liver carcinogenesis,and the involvement of the Wnt/β-catenin signaling pathway.Diwu Yanggan capsule was administered to 2-acetaminofluorene/partial hepatectomy(2-AAF/PH)rats,a murine model of liver injury.The biomarkers of oval cells and key proteins in the Wnt/p-catenin signaling pathway were assessed on postoperative day 8,10,14,17,19 and 22.The results showed that treatment with Diwu Yanggan was associated with reduced expression of oval cell and stem cell biomarkers in the 2-AAF/PH animals.The expression pattern of key proteins in the Wnt/β-catenin pathway was altered in Diwu Yanggan-treated animals,indicating that the Diwu Yanggan treatment accelerated the activation of the Wnt/β-catenin pathway in the initial stage and contributed to its deactivation in the later stage.Histological findings indicated that hepatocyte proliferation was suppressed in Diwu Yanggan-treated animals,compared with untreated 2-AAF/PH animals.Taken together,Diwu Yanggan capsule may reduce the risk of hepatocarcinogenesis by modulating the Wnt/β-catenin signaling pathway.

On the two-layer high-level Green-Naghdi model in a general form

The traditional high-level Green-Naghdi(HLGN)model,which uses the polynomial as the shape function to approximate the variation of the horizontal-and vertical-velocity components along the vertical direction for each-fluid layer,can accurately describe the large-amplitude internal waves in a two-layer system for the shallow configuration(h_(2)/λ■1,h_(1)/λ■1).However,for the cases of the deep configuration(h_(2)/λ■1,h_(1)/λ=O(1)),higher-order polynomial is needed to approximate the variation of the velocity components along the vertical direction for the lower-fluid layer.This,however,introduces additional unknowns,leading to a significant increase in computational time.This paper,for the first time,derives a general form of the HLGN model for a two-layer fluid system,where the general form of the shape function is used during the derivation.After obtaining the general form of the two-layer HLGN equations,corresponding solutions can be obtained by determining the reasonable shape function.Large-amplitude internal solitary waves in a deep configuration are studied by use of two different HLGN models.Comparison of the two HLGN models shows that the polynomial as the shape function for the upper-fluid layer and the production of exponential and polynomial as the shape function for the lower-fluid layer is a good choice.By comparing with Euler’s solutions and the laboratory measurements,the accuracy of the two-layer HLGN model is verified.

Experiments and calculations of wave breaking and evolution of wave groups with high steepness

The evolution of the nonlinear wave groups in deep water is investigated through laboratory measurements and numerical analysis.Laboratory experiments are conducted in deep-water wave tank,focusing on the characteristics of breaking waves arising from the evolved wave train.Some quantitative results are obtained for the significant breaking wave train,including the surface elevation time series,the local geometry,and the energy dissipation.A nonlinear model for the evolution of the wave groups in deep water is developed by adding eddy viscosity dissipation terms in the High Level Irrotational Green-Naghdi(HLIGN)equations.The results of the simulation are compared with the laboratory measurements,and good agreement is observed for the evolved wave train.

Mid-infrared hyperchaos of interband cascade lasers

Chaos in nonlinear dynamical systems is featured with irregular appearance and with high sensitivity to initial conditions.Near-infrared light chaos based on semiconductor lasers has been extensively studied and has enabled various applications.Here,we report a fully-developed hyperchaos in the mid-infrared regime,which is produced from interband cascade lasers subject to the external optical feedback.Lyapunov spectrum analysis demonstrates that the chaos exhibits three positive Lyapunov exponents.Particularly,the chaotic signal covers a broad frequency range up to the GHz level,which is two to three orders of magnitude broader than existed mid-infrared chaos solutions.The interband cascade lasers produce either periodic oscillations or low-frequency fluctuations before bifurcating to hyperchaos.This hyperchaos source is valuable for developing long-reach secure optical communication links and remote chaotic Lidar systems,taking advantage of the high-transmission windows of the atmosphere in the mid-infrared regime.

On solitary wave in nonuniform shear currents

In this paper,steady solutions of solitary waves in the presence of nonuniform shear currents are obtained by use of the high-level Green-Naghdi(HLGN)model.We focus on large-amplitude solitary waves in strong opposing shear currents.The linear-type currents,quadratic-type currents and cubic-type currents are considered.In particular,the wave speed,wave profile,velocity field,particle trajectories and vorticity distribution are studied.It is demonstrated that presence of the nonuniform shear current modifies the velocity field and vorticity field of the solitary wave.