Under the conditions of phase transfer catalysis and nitrobenzene as the solvent,the halogen-exchange flu-orination of 2,6-dichlorobenzaldehyde using KF as fluorin-ating agent was studied.The kinetics was investigated...Under the conditions of phase transfer catalysis and nitrobenzene as the solvent,the halogen-exchange flu-orination of 2,6-dichlorobenzaldehyde using KF as fluorin-ating agent was studied.The kinetics was investigated and the reaction rate constants were obtained under the optimumconditionsofn(KF):n(2,6-dichlorobenzaldehyde):n(Ph 4 PBr):n(acetone-furan crown ether)54:1:0.1:0.05 and temperatures of 433 K,443 K,453 K and 463 K.The results illustrated the activation energy of the first and the second step is 4.57×10^(4)J·mol^(-1) and 3.53×10^(4)J·mol^(-1),respectively.The pre-exponential factor is 4.50×10^(5) h^(-1) and 1.08×10^(5) h^(-1),respectively.Thus a reliable kinetics data could be obtained for further research.展开更多
A mild and efficient methodology for the direct oxidative synthesis of nitriles from easily available alcohols and aqueous ammonia by employing CuCI/DABCO/4-HO-TEMPO as the catalysts is described. This protocol uses t...A mild and efficient methodology for the direct oxidative synthesis of nitriles from easily available alcohols and aqueous ammonia by employing CuCI/DABCO/4-HO-TEMPO as the catalysts is described. This protocol uses the air as a green oxidant and aqueous ammonia as the nitrogen source at room temperature, A variety of aryl, heterocyclic and allylic alcohols are smoothly converted into the corresponding nitriles in good to excellent yields.展开更多
文摘Under the conditions of phase transfer catalysis and nitrobenzene as the solvent,the halogen-exchange flu-orination of 2,6-dichlorobenzaldehyde using KF as fluorin-ating agent was studied.The kinetics was investigated and the reaction rate constants were obtained under the optimumconditionsofn(KF):n(2,6-dichlorobenzaldehyde):n(Ph 4 PBr):n(acetone-furan crown ether)54:1:0.1:0.05 and temperatures of 433 K,443 K,453 K and 463 K.The results illustrated the activation energy of the first and the second step is 4.57×10^(4)J·mol^(-1) and 3.53×10^(4)J·mol^(-1),respectively.The pre-exponential factor is 4.50×10^(5) h^(-1) and 1.08×10^(5) h^(-1),respectively.Thus a reliable kinetics data could be obtained for further research.
文摘A mild and efficient methodology for the direct oxidative synthesis of nitriles from easily available alcohols and aqueous ammonia by employing CuCI/DABCO/4-HO-TEMPO as the catalysts is described. This protocol uses the air as a green oxidant and aqueous ammonia as the nitrogen source at room temperature, A variety of aryl, heterocyclic and allylic alcohols are smoothly converted into the corresponding nitriles in good to excellent yields.
