目的探讨P53基因与鼻腔鼻窦内翻性乳头状瘤(SNIP)恶变的关系。方法选用Pubmed、Web of science、Embase、Cochrane Library、CNKI、维普、中国知网及万方等数据库(1998-2017)检索国内外发表的P53基因表达与SNIP关系的病例对照研究,应用R...目的探讨P53基因与鼻腔鼻窦内翻性乳头状瘤(SNIP)恶变的关系。方法选用Pubmed、Web of science、Embase、Cochrane Library、CNKI、维普、中国知网及万方等数据库(1998-2017)检索国内外发表的P53基因表达与SNIP关系的病例对照研究,应用Rev Man5.3统计软件对各研究的原始数据进行统计分析。结果Meta分析示恶变组P53阳性率明显高于SNIP组(P0.05,OR=1.37,95%CI为0.59~3.20);SNIP组P53阳性率与对照组无明显差异(P=0.47>0.05,OR=5.32,95%CI为0.78~36.39)。结论P53的异常表达与SNIP的恶变密切相关,而与SNIP的发生及复发无关。展开更多
Montmorillonite (MMT) was modified through intercalative polymerization of phenol and formaldehyde catalyzed by oxalic acid. The modified montmorillonite was delaminated at large, as demonstrated by XRD and TEM studi...Montmorillonite (MMT) was modified through intercalative polymerization of phenol and formaldehyde catalyzed by oxalic acid. The modified montmorillonite was delaminated at large, as demonstrated by XRD and TEM studies. It can disperse easily in epoxy resin to form exfoliated nanocomposites. The nanoscale silicate platelets dispersed in water can be metallized by silver deposition.展开更多
The photoluminescence （PL） characteristics of Eu^3＋ and Li^＋ co-doped ZnO PL materials against heat-treatment temperature were discussed. The PL xerogel and powder samples were prepared by solgel process. The emis...The photoluminescence （PL） characteristics of Eu^3＋ and Li^＋ co-doped ZnO PL materials against heat-treatment temperature were discussed. The PL xerogel and powder samples were prepared by solgel process. The emission spectra of all samples showed two broad bands peaking at 590 nm and 620 nm under UV-Vis excitation. But the relative intensity of red PL （620 nm） was much greater than that of green PL （590 nm） of the same sample, that s to say, the red color was the main luminescence. With heat-treatment temperature increase, the two kinds of colors PL intensity decreased, and both the red and green PL intensity of the xerogel samples was much greater than those of powder samples respectively. The XRD patterns revealed that Eu^3＋ ions were successfully incorporated in ZnO crystals in xerogel samples. When heat-treatment temperature reached 350 ℃, the Eu^3＋ began to separate out of the ZnO crystals and Eu2O3 crystals came into being. When the powder sample was subjected to UV-Vis excitation, the energy transfered from the host ZnO emission to Eu^3＋ became weaker than the xerogel sample.展开更多
A new ionic conductor La2-xNdxMo2O9 (x=0.0-2.0) has been synthesized by wet- chemistry method. The precursors and the resultant oxide powders were characterized by DTA/TG, DSC, XRD and XPS techniques. Effect of subs...A new ionic conductor La2-xNdxMo2O9 (x=0.0-2.0) has been synthesized by wet- chemistry method. The precursors and the resultant oxide powders were characterized by DTA/TG, DSC, XRD and XPS techniques. Effect of substituting Nd for La reveals that the phase transition which occurs in La2Mo2O9 around 565℃ disappears when x>0.2. And the maximum amount of Nd stabilized the high temperature phase of βLa2Mo2O9 from cubic to tetragonal is about x =1.6. The measurements of impedance spectroscopy indicate that the ionic conductivity becomes considerably higher in comparison to that of La2Mo2O9.展开更多
Objective: To compare the expression of Epstein-Barr virus encoded LMP1 and E-cadherin/β-catenin in primary and metastatic nasopharyngeal carcinoma (NPC) for the purpose of understanding their relationship. Methods: ...Objective: To compare the expression of Epstein-Barr virus encoded LMP1 and E-cadherin/β-catenin in primary and metastatic nasopharyngeal carcinoma (NPC) for the purpose of understanding their relationship. Methods: Twenty-two pairs of biopsies taken from the nasopharynx and cervical lymph node(s) of the same patient with nasopharyngeal carcinoma were collected. The expression of LMP1, E-cadherin and β-catenin was observed on immunostained slides using LSAB method. Results: The expression rate of LMP1 in the 22 metastatic tumors (86.36%, 19/22) was significantly higher than that in the 22 primary growths (68.18%, 15/22), P<0.05. The mean expression percentages of E-cadherin and β-catenin in metastatic tumors (50.11%±22.53% and 66.36±21.05%, respectively) were significantly lower than those in primary growths (71.52±24.34 % and 79.40%±15.05%, respectively), P<0.05. There was a positive correlation between the expressions of E-cadherin and β-catenin either in primary growths or metastatic tumors. Conclusion: The LMP1 is more likely to be expressed in metastatic neoplastic cells of NPC than in primary carcinoma cells, and on the contrary the expression of E-cadherin/β-catenin in metastatic cells was decreased. Accordingly, the LMP1 might have the ability to downregulate the expression of E-cadherin/β-catenin, resulting in enhancement of the invasive capacity of metastatic NPC cells.展开更多
Objective: To seek for a new method of integrated Chinese and western medicine in treating ankylosing spondylitis (AS) to control the disease development, shorten the therapeutic course and lower disability rate. Meth...Objective: To seek for a new method of integrated Chinese and western medicine in treating ankylosing spondylitis (AS) to control the disease development, shorten the therapeutic course and lower disability rate. Methods: Patients of AS enrolled in this study were 106 cases in Group A, who were persistently treated with traditional Chinese medicine and western medicine (TCM WM) for over 10 months, 48 cases in Group B treated with WM and 34 cases in Group C treated with non steroid anti inflammatory and analgesic agents. They were followed up for 2 years. Results: (1) Short term effect: The markedly effective rate in the 3 groups was 73.58%, 47.92% and 5.88% respectively, and the total effective rate was 96.23%, 87.50% and 41.18% respectively. The comparison of Group A with Group B and C showed significant difference, the effect in Group A was superior to that in Group B and Group C (χ 2=10.58, P <0.01 and χ 2=67.76, P <0.01 respectively). (2) Results of 2 year follow up: the recurrence rate in Group A was 18.37% (9/49), it was insignificantly different from that in Group B (7/23, 30.43%,χ 2=1.32, P >0.05), but significantly different from that in Group C (8/12, 66.67%,χ 2=11.19, P <0.01). Conclusion: Long term TCM WM therapy, which combined the advantages of Chinese and western medicine, was a practical method in treating AS with reliable effect, few side effects, and therefore is worth popularizing.展开更多
文摘目的探讨P53基因与鼻腔鼻窦内翻性乳头状瘤(SNIP)恶变的关系。方法选用Pubmed、Web of science、Embase、Cochrane Library、CNKI、维普、中国知网及万方等数据库(1998-2017)检索国内外发表的P53基因表达与SNIP关系的病例对照研究,应用Rev Man5.3统计软件对各研究的原始数据进行统计分析。结果Meta分析示恶变组P53阳性率明显高于SNIP组(P0.05,OR=1.37,95%CI为0.59~3.20);SNIP组P53阳性率与对照组无明显差异(P=0.47>0.05,OR=5.32,95%CI为0.78~36.39)。结论P53的异常表达与SNIP的恶变密切相关,而与SNIP的发生及复发无关。
文摘Montmorillonite (MMT) was modified through intercalative polymerization of phenol and formaldehyde catalyzed by oxalic acid. The modified montmorillonite was delaminated at large, as demonstrated by XRD and TEM studies. It can disperse easily in epoxy resin to form exfoliated nanocomposites. The nanoscale silicate platelets dispersed in water can be metallized by silver deposition.
基金the National Defense Foundation Research Item of China(No.K 1203061109)
文摘The photoluminescence （PL） characteristics of Eu^3＋ and Li^＋ co-doped ZnO PL materials against heat-treatment temperature were discussed. The PL xerogel and powder samples were prepared by solgel process. The emission spectra of all samples showed two broad bands peaking at 590 nm and 620 nm under UV-Vis excitation. But the relative intensity of red PL （620 nm） was much greater than that of green PL （590 nm） of the same sample, that s to say, the red color was the main luminescence. With heat-treatment temperature increase, the two kinds of colors PL intensity decreased, and both the red and green PL intensity of the xerogel samples was much greater than those of powder samples respectively. The XRD patterns revealed that Eu^3＋ ions were successfully incorporated in ZnO crystals in xerogel samples. When heat-treatment temperature reached 350 ℃, the Eu^3＋ began to separate out of the ZnO crystals and Eu2O3 crystals came into being. When the powder sample was subjected to UV-Vis excitation, the energy transfered from the host ZnO emission to Eu^3＋ became weaker than the xerogel sample.
基金supported by the State Key Program of Basic Research (G1998061311) and the National Natural Science Foundation of China (29831010).
文摘A new ionic conductor La2-xNdxMo2O9 (x=0.0-2.0) has been synthesized by wet- chemistry method. The precursors and the resultant oxide powders were characterized by DTA/TG, DSC, XRD and XPS techniques. Effect of substituting Nd for La reveals that the phase transition which occurs in La2Mo2O9 around 565℃ disappears when x>0.2. And the maximum amount of Nd stabilized the high temperature phase of βLa2Mo2O9 from cubic to tetragonal is about x =1.6. The measurements of impedance spectroscopy indicate that the ionic conductivity becomes considerably higher in comparison to that of La2Mo2O9.
基金This work was supported by the National Natural Science Foundation of China (No. 39730200-II).
文摘Objective: To compare the expression of Epstein-Barr virus encoded LMP1 and E-cadherin/β-catenin in primary and metastatic nasopharyngeal carcinoma (NPC) for the purpose of understanding their relationship. Methods: Twenty-two pairs of biopsies taken from the nasopharynx and cervical lymph node(s) of the same patient with nasopharyngeal carcinoma were collected. The expression of LMP1, E-cadherin and β-catenin was observed on immunostained slides using LSAB method. Results: The expression rate of LMP1 in the 22 metastatic tumors (86.36%, 19/22) was significantly higher than that in the 22 primary growths (68.18%, 15/22), P<0.05. The mean expression percentages of E-cadherin and β-catenin in metastatic tumors (50.11%±22.53% and 66.36±21.05%, respectively) were significantly lower than those in primary growths (71.52±24.34 % and 79.40%±15.05%, respectively), P<0.05. There was a positive correlation between the expressions of E-cadherin and β-catenin either in primary growths or metastatic tumors. Conclusion: The LMP1 is more likely to be expressed in metastatic neoplastic cells of NPC than in primary carcinoma cells, and on the contrary the expression of E-cadherin/β-catenin in metastatic cells was decreased. Accordingly, the LMP1 might have the ability to downregulate the expression of E-cadherin/β-catenin, resulting in enhancement of the invasive capacity of metastatic NPC cells.
文摘Objective: To seek for a new method of integrated Chinese and western medicine in treating ankylosing spondylitis (AS) to control the disease development, shorten the therapeutic course and lower disability rate. Methods: Patients of AS enrolled in this study were 106 cases in Group A, who were persistently treated with traditional Chinese medicine and western medicine (TCM WM) for over 10 months, 48 cases in Group B treated with WM and 34 cases in Group C treated with non steroid anti inflammatory and analgesic agents. They were followed up for 2 years. Results: (1) Short term effect: The markedly effective rate in the 3 groups was 73.58%, 47.92% and 5.88% respectively, and the total effective rate was 96.23%, 87.50% and 41.18% respectively. The comparison of Group A with Group B and C showed significant difference, the effect in Group A was superior to that in Group B and Group C (χ 2=10.58, P <0.01 and χ 2=67.76, P <0.01 respectively). (2) Results of 2 year follow up: the recurrence rate in Group A was 18.37% (9/49), it was insignificantly different from that in Group B (7/23, 30.43%,χ 2=1.32, P >0.05), but significantly different from that in Group C (8/12, 66.67%,χ 2=11.19, P <0.01). Conclusion: Long term TCM WM therapy, which combined the advantages of Chinese and western medicine, was a practical method in treating AS with reliable effect, few side effects, and therefore is worth popularizing.
