As an important intermediate to study cyclin-dependent kinase （CDK） inhibitors, 2-ary1-8-（piperidin-4-y1）-5,7-dimethoxy-4H- chromen-4-one derivatives were prepared using 13-diketone route with low yield. In our st...As an important intermediate to study cyclin-dependent kinase （CDK） inhibitors, 2-ary1-8-（piperidin-4-y1）-5,7-dimethoxy-4H- chromen-4-one derivatives were prepared using 13-diketone route with low yield. In our study, chalcone route has been investigated and the result suggested that the benzaldehydes substituted with electron-donating group give much better yield than β-diketone route. This new method will be an efficient way to start further research on new anticancer flavonoids.展开更多
基金We are grateful to the National Natural Science Foundation of China （No. 20272033） for financial support for this work.
文摘As an important intermediate to study cyclin-dependent kinase （CDK） inhibitors, 2-ary1-8-（piperidin-4-y1）-5,7-dimethoxy-4H- chromen-4-one derivatives were prepared using 13-diketone route with low yield. In our study, chalcone route has been investigated and the result suggested that the benzaldehydes substituted with electron-donating group give much better yield than β-diketone route. This new method will be an efficient way to start further research on new anticancer flavonoids.
