Efficient adsorption separation of methane from C_(2)-C_(3) hydrocarbons in a Co(Ⅱ)-nodes metal-organic framework

Methane(CH_(4))as a substitute for other mineral fuels plays a crucial role in reducing energy consumption and preventing environmental pollution.The present study employs a solvothermal method to fabricate a porous framework Co-metal-organic framework(Co-MOF)containing two distinct secondary building units(SBUs):an anionic[Co_(2)(μ_(2)-OH)(COO)_(4)(H_(2)O)]and a neutral[CoN_(2)(COO)_(2)].Notably,within the anionic SBUs,the coordinated water molecules induce the generation of divergent unsaturated Co(Ⅱ)centers in the unidirectional porous channels,thereby creating open metal sites.The adsorption performance of Co-MOF towards pure component gases was systematically investigated.The results demonstrated that Co-MOF exhibits superior adsorption capacity for C_(2)-C_(3) hydrocarbons compared to CH_(4),which offers the potential for efficient adsorption and separation of CH_(4) from C_(2)-C_(3) hydrocarbons.The gas selectivity separation ratios of Co-MOF for C_(2)H_(6)/CH_(4) and C_(3)H_8/CH_(4) were calculated using the ideal adsorbed solution theory method at 273/298 K and 0.1 MPa.The results revealed that Co-MOF achieved remarkable equilibrium separation selectivity for CH_(4) and C_(2)-C_(3) hydrocarbon gases among non-modified MOFs,signifying the potential of the synthesized Co-MOF for efficient recovery and purification of CH_(4) from C_(2)-C_(3) hydrocarbons.Breakthrough experiments further demonstrate the ability of Co-MOF to purify methane from C_(2)-C_(3) hydrocarbons in practical gas separation scenarios.Additionally,molecular simulation calculations further substantiate the propensity of anionic SBUs to interact with C_(2)-C_(3) hydrocarbon compounds.This study provides a novel paradigm for the development of porous MOF materials in the application of gas mixture separation.

可见光介导多组分一锅法合成仲胺化合物及其机理探究

将有机光化学领域的前沿研究引入到本科实验教学中,以苯甲醛、苯胺和4-异丙基-1,4-二氢吡啶作为起始原料,在温和条件下进行可见光介导的一锅法串联反应,实现了仲胺化合物的制备。实验具有原料廉价易得、反应条件温和、安全性高、操作简单等特点,同时融入绿色化学理念和有机合成方法学的实验探究过程,适用于本科实验教学,可帮助学生在熟练实验操作的同时,增强对光化学反应、一锅法串联反应、自由基反应等知识的理解。本实验将新的科研成果转化为人才培养内容,有助于提高学生的科研创新与实践能力。

Focal choroidal excavation: a preliminary interpretation based on clinic and review

AIM: To describe the clinical and imaging characteristics associated with focal choroidal excavation(FCE), analyze the possible complication, and interpret its probable etiopathogenesis.METHODS: Retrospective descriptive case series of 37 eyes of 32 patients with FCE. Findings of spectral-domain optical coherence tomography(SD-OCT),fluorescein angiography, indocyanine green angiography,and clinical features were analyzed. RESULTS: All patients were Chinese. Five patients(15.6%) were bilaterally involved. Patients’ ages ranged from 7 to 66 y. Refractive error ranged between +2.0 D and 11.0 D. Mean best-corrected visual acuity was 0.6(range, 0.1 to 1.2). Fundus examinations exhibited mild-moderate localized pigmentary disturbances in the corresponding area of 17 eyes. Fluorescein angiography performed in 18 patients showed varying degrees of hyperfluorescence and hypofluorescence related to a range of retinal pigment epithelium(RPE) alterations.Indocyanine green angiography performed in 7 patients showed hypofluorescence at the excavation. SD-OCT demonstrated choroidal excavation in all 37 eyes.Twenty-nine eyes showed a single lesion of FCE, and three eyes showed 2-3 separated lesions. Fifteen eyes showed separation between the photoreceptor tips andRPE consistent with nonconforming FCE. Central serous chorioretinopathy(CSC, n =1) and choroidal neovascularization(CNV, n =1) developed during follow-up.CONCLUSION: FCE could be interpreted as congenital focal choroidal dysplasia involving the RPE,choriocapillaris, and photoreceptor associated with the faulty anatomy. The abnormal anatomy of FCE was similar to anatomy at risk of CSC and CNV.

Clinic pathological features and prognosis of metaplastic breast carcinoma

Objective:To investigate clinic pathological peculiarities and evaluate the prognosis of metaplastic breast carcinoma.Methods:Patients with metaplastic breast carcinoma at the First Affiliated Hospital of Zhejiang University and Guangxing Hospital Affiliated Hospital of Zhejiang University of Traditional Chinese Medicine from 2008 to 2013 were retrospectively selected.Results:A total of 73 female patients were reviewed,including 41 cases of purely epithelial type and 32 cases of mixed epithelial and mesenchymal type.Median tumor size was 4.6cm.Forty-three patients(58.8%)presented with lymph node metastasis,84.9%of cases were in advanced TNM stage,and 60.2%of cases were overexpressed by Ki-67.At a median follow-up of 59 months,median overall survival and disease-free survival were 59.7 and 43.9 months,respectively.Five-year overall survival rate was 45.2%and disease-free survival rate was 30.1%,and 76.7%of patients had recurrence or metastasis.Univariate analysis showed that tumor size,lymph node,and radiotherapy were associated with overall survival and disease-free survival(P<0.05),while Ki-67 over-expression was correlated with overall survival(P<0.05).With multivariate analysis,tumor size,lymph node,and radiotherapy affected prognosis(P<0.05);however,pathological typing was not an independent prognostic factor(P>0.05).Conclusion:Metaplastic breast carcinoma is a rare malignant tumor with large tumor,high lymph node metastasis rate,staging relatively late,high local recurrence and distant metastasis rate.The treatment follows the principle of comprehensive treatment based on surgery,but the prognosis is poor.Tumor size,lymph node,and radiotherapy treatment affect the prognosis.Overexpression of Ki-67 can be used as a potential diagnostic,therapeutic and prognostic indicator for metaplastic breast cancer.

Retinal laser photocoagulation and intravitreal injection of anti-VEGF for hemorrhagic retinal arterial microaneurysm

AIM:To evaluate the efficacy of retinal laser photocoagulation and intravitreal injection of anti-vascular endothelial growth factor(anti-VEGF)for hemorrhagic retinal arterial macroaneurysm(RAM).METHODS:This was a retrospective clinical study.Patients with hemorrhagic RAM were divided into 4 groups defined by different treatments:a retinal laser photocoagulation therapy monotherapy group,an anti-VEGF intravitreal injection monotherapy group,a laser and anti-VEGF combination therapy group,and an observation group.Visual acuity(VA),central macular thickness(CMT),and retinal hemorrhage area(RHA)were collected.RESULTS:Forty-seven eyes of 47 patients were enrolled.VA improved and had a significant difference between baseline and final in each treatment group(logMAR;laser group:1.90±0.53 vs 1.05±0.63,P<0.001;anti-VEGF group:1.75±0.63 vs 1.12±0.54,P=0.009;combination group:1.76±0.38 vs 1.01±0.52,P<0.001);however,VA decreased and had no significant difference in observation group(1.63±0.51 vs 1.76±0.61,P=0.660).CMT decreased and had a significant difference between baseline and final in each group(laser group:815.16±310.83 vs 252.05±83.90μm,P<0.001;anti-VEGF group:725.00±290.79 vs 203.56±69.89μm,P=0.001;combination group:595.50±186.51 vs 253.13±55.06μm,P=0.001;observation group:758.88±195.65 vs 267.00±120.90μm,P=0.001).RHA were 28.99±28.15,25.94±11.58,19.64±8.97,and 27.45±13.76 mm^(2) in laser group,anti-VEGF group,combination group and observation group,respectively.RHA was statistically correlated with final VA(P=0.032)in the observation group.CONCLUSION:Both laser and anti-VEGF treatments are effective for hemorrhagic RAM.Combination therapy reduces the number of injections of anti-VEGF.RHA is a visual prognosis predictor in the natural history of hemorrhagic RAM.

Optical coherence tomography angiography characteristics of exudative and non-exudative treatmentnaive pachychoroid neovasculopathy

AIM:To describe the optical coherence tomography angiography(OCTA)characteristics of exudative and nonexudative treatment-naïve pachychoroid neovasculopathy(PNV).METHODS:Thirty-five patients with exudative treatmentnaïve PNV and 13 with non-exudative treatment-naïve PNV between March 2020 and December 2021 were included.All patients underwent ophthalmologic examination,including fluorescein angiography(FA),indocyanine green angiography(ICGA),spectral-domain OCT,and OCTA.The clinical data of the patients were retrospectively analyzed.RESULTS:The study included 51 eyes from 46 patients,of whom 33(71.7%)were male.The central macular thickness(CMT)in the exudative PNV group was significantly higher than that in the non-exudative PNV group(383.97±132.16μm vs 213.13±51.63μm;P<0.001).The maximum height of flat irregular pigment epithelial detachments(FIPED)was 45.40±11.86μm in the non-exudative PNV group,significantly lower than the 71.58±20.91μm(P<0.001)in the exudative PNV group.The area of PNV of the non-exudative PNV group was,significantly larger than that of the exudative PNV group(1.06±0.84 mm2 vs 0.63±0.80 mm2,P=0.016).There was a significant difference in PNV morphology between the two groups(P<0.001).Multivariate logistic regression analysis found that the maximum height of FIPED(OR=1.156,95%CI:1.019-1.312;P=0.024)and microvascular branches(OR=69.412,95%CI:3.538-1361.844;P=0.005)were independent predictors of PNV activity.CONCLUSION:The OCTA imaging finds that there are significant differences in CMT,maximum height of FIPED,PNV area,and morphology of exudative PNV and non-exudative PNV groups.OCTA can accurately identify the clinical and imaging features of exudative and nonexudative treatment-naïve PNV,and distinguish PNV activity.

奥沙利铂注射液致心搏骤停1例

1例49岁女性胃窦印戒细胞癌患者,既往已行根治性胃大部切除术和10周期含奥沙利铂方案化疗。在接受第11周期化疗输注奥沙利铂注射液后约2 min患者突然出现心搏骤停。立即停用奥沙利铂,并予以心肺复苏、辅助呼吸,静脉注射肾上腺素、去甲肾上腺素等抢救治疗后逐渐好转出院。分别采用诺氏评估量表和我国药品不良反应监测中心的关联性评价方法进行药品不良反应关联性评价,判断患者心搏骤停“很可能”由奥沙利铂引起。结合该病例查阅相关文献并进行复习,奥沙利铂诱导的过敏性心脏毒性可能会危及生命,这种严重的不良反应难以预测和预防,在临床使用该药时应在整个输注过程进行密切监测。

Melanin change of retinal pigment epithelium and choroid in the convalescent stage of Vogt-Koyanagi-Harada disease

AIM:To observe the melanin change of the retinal pigment epithelium(RPE)and choroid in the convalescent stage of Vogt-Koyanagi-Harada(VKH).METHODS:A retrospective study was performed on 40 eyes of 20 patients in the convalescent stage of VKH.Fundus photography(FP),multi-spectral imaging(MSI),and optical coherence tomography(OCT)were performed.RESULTS:In the VKH convalescent stage,focal RPE melanin accumulation(FRMA)was detected in 34 eyes(85%)on MSI and in 7 eyes(17.5%)on FP.FRMA was limited to the previous retinal detachment area in all 28 eyes(FRMA was detected in 34 eyes on MSI,which were enrolled,and 6 eyes lacked data in the acute stage).Sunset-glow fundus was detected in 20 eyes(50%)on FP.The mean density of FRMA in a 1-mm-diameter circular area of the fovea was 0.04±0.07 on MSI,which was significantly correlated with sunset-glow fundus(ρ=0.467,P=0.02).CONCLUSION:In the VKH convalescent stage,FRMA is derived from the RPE melanin change,and sunset-glow fundus is derived from the choroid melanin change.A higher density of FRMA in the fovea and sunset-glow fundus represents more serious depigmentation of melanin.

Conducting a Correlation Model Between TCM Constitution and Physical Examination Index Based on BPNN Algorithm

This paper studies the correlation between Traditional Chinese Medicine(TCM)Constitution discrimination and physical examination index based on BPNN algorithm.253cases of routine urine test were used to build a linkage model between TCM Constitution and physical indicators via BPNN algorithm.According to the test,the correct rate of learning and test group are60%and40%,respectively.A strong correlation was found between TCM Constitution and physical examination indexes.By applying cutting-edge knowledge and technologies,the development and modernization process of TCM can be greatly promoted.

Study on Thin Layer Drying of <i>Rosa laevigata</i>Michx

The drying process of traditional Chinese medicine Rosa laevigata Michx was investigated in a laboratory scale dryer. Drying experiments were conducted at five temperatures of 40℃, 50℃, 60℃, 70℃ and 80℃. The experimental data were fitted to ten different thin layer drying models to select a suitable model for describing the drying process of Rosa laevigata Michx fruits. The results showed that the Midilli model had the highest value of R2 (0.999767), the lowest χ2 (0.000034) and RMSE (0.003616) among the ten models considered. The drying process of Rosa laevigata Michx fruits consisted of 1st falling rate period and 2nd falling rate period. The effective moisture diffusivity was found in the range of 1.49 - 30.20 × 10-11 m2·s-1. The value of activation energy obtained by plotting lnD versus 1/T is about 36 kJ·mol-1.

Constitution Identification System for Traditional Chinese Medicine (TCM) Based on Correlation Between TCM Constitution and Physical Examination Indices

Objective Identification of one’s constitution based on a combination of features and back propagation neural network theory is needed in modern medicine and traditional Chinese medicine(TCM).We describe a method to identify one’s constitution based on TCM constitution classification and a physical index model.Methods We created a constitution identification system based on neural network using Visio Studio development tool.We report the initial implementation of the system,the accuracy of which was verified using actual data.Results We found a relatively strong correlation between TCM constitution and physical indicators.Conclusion Finally,our report describes a possible application of the proposed system.

薄膜中的扩散与应力模型

扩散会产生应力,而产生的或内禀的应力又会影响扩散,这在薄膜材料中表现的尤为突出。本文介绍了常见的几个扩散模型和应力模型,并通过热力学的方法推导出了应力条件下的扩散方程。随后采用有限元差分方法模拟了不同应力模型下的扩散分布。

Design of Implant Prosthesis for Bone Injury Repair Considering Stress Shielding Effect

The failure of bone injury repair surgery is mostly due to the stress shielding effect caused by the difference of elastic modulus between the implant prosthesis and human bone,result-ing in a great damage to patients.To solve this problem,in this study,the influencing factors of the elastic modulus of implant prosthesis were investigated,the relationship between the elastic modulus of the implanted prosthesis and the influencing factors was analyzed,and then a design method of the implant prosthesis to reduce the stress shielding effect by adjusting the unit module to control the elastic modulus was established.This method was used for the biomechanical simula-tion to simulate the displacement and stress distribution between the implant prosthesis and the surrounding bone tissue,and then the reliability of the method was verified.The implant prosthe-sis with an elastic modulus consistent with that of the experimental dog bone was made by this method,and used for the animal experiments.The effects of implant prosthesis with different mod-ulus on the growth of surrounding bone tissue were observed,and at the same time,the reliability of the implant design method and the results of biomechanical simulation were verified.It is con-firmed that this method can effectively reduce the stress concentration of implant prosthesis by more than 15.4%and increase the growth of bone tissue by more than 21%.

Scleral tunnel leakage induced by injection of dexamethasone intravitreal implant for recurrent Vogt-Koyanagi-Harada disease:a case report

Citation:Huang Y,Lin B,Ge LN,Liu XL.Scleral tunnel leakage induced by injection of dexamethasone intravitreal implant for recurrent Vogt-Koyanagi-Harada disease:a case report.Int J Ophthalmol 2021;14(12):1986-1987 Dear Editor,We present a case of scleral tunnel leakage induced by injection of dexamethasone intravitreal implant(Ozurdex®)for recurrent Vogt-Koyanagi-Harada(VKH)disease.Written informed consent was obtained by the patient to allow publication of the present case and any related image and this case study is in accordance with the tenets of the Declaration of Helsinki.

影响出血型息肉状脉络膜血管病变治疗预后的出血特征

目的:探讨影响出血型息肉状脉络膜血管病变(PCV)疗效的出血特征。方法:前瞻性研究。收集2015年1月到2017年12月在温州医科大学附属眼视光医院眼底内科就诊的新发PCV经治疗且随访至少3个月的患者。根据基线视网膜下出血面积是否>4视盘面积(DA),出血是否累及黄斑中心凹,出血中心位于早期糖尿病视网膜病变治疗研究(ETDRS)环位置等进行分组,观察各组治疗前后LogMAR视力变化,分析影响出血型PCV治疗后视力的出血特征。采用混合线性模型进行统计分析。结果:共收集患者122例(124眼),其中男84例,女38例,年龄(64.9±9.8)岁。基线有视网膜下出血69眼(55.6%)。其中,出血>4 DA的34眼(49.3%)治疗后视力较基线改善程度不如≤4 DA者明显,但差异无统计学意义。基线出血累及中心凹59眼(85.5%)治疗后视力较基线改善程度不如未累及者明显(F=3.92,P=0.01)。出血累及中心凹的59眼中,出血中心位于ETDRS 1环的25眼(42.4%)治疗后视力较基线改善程度不如2、3环明显(F=2.23,P=0.05)。结论:视网膜下出血面积大,出血累及中心凹,出血中心距黄斑中心凹近,是伴有视网膜下出血PCV患者视力预后差的特征因素。