Gastrointestinal symptoms as the first sign of chronic granulomatous disease in a neonate: A case report

BACKGROUND Chronic granulomatous disease(CGD)characterized by recurrent and severe bacterial and fungal infections is most common in childhood.CASE SUMMARY We reported a 24-d-old male infant who developed gastrointestinal symptoms as the first sign of CGD.CONCLUSION Gastrointestinal symptoms representing the first sign of CGD are very rare,and prompt diagnosis and treatment with broad-spectrum antibiotics were of crucial importance.

Thermal-sensitive ionogel with NIR-light controlled adhesion for ultrasoft strain sensor

With the widespread prevailing of flexible electronics in human-machine interfaces,health monitor,and human motion detection,ultrasoft flexible sensors are urgently desired with critical demands in conformality.Herein,a temperature-sensitive ionogel with near-infrared(NIR)-light controlled adhesion is prepared by electrostatic interaction of poly(diallyl dimethylammonium chloride)(PDDA)and acrylic acid,as well as the incorporation of the conductive polydopamine modified polypyrrole nanoparticles(PPy-PDA NPs).The PPy-PDA NPs could weaken the tough interaction between polymer chains and depress the Young’s modulus of the ionogel,thus promoting the ionogel ultrasoft(34 kPa)and highly stretchable(1,013%)performance to tensile deformations.In addition,the high photothermal conversion capacity of PPy-PDA NPs ensured the ionogel excellent NIR-light controlled adhesion and temperature sensitivity,which facilitated the ionogel on-demand removal and promised a reliable thermal sensor.Moreover,the resulted ultrasoft flexible sensor exhibited high sensitivity and stability to both strain and pressure in a broad range of deformations,enabling a precise monitoring on various human motions and physiological activities.The temperature-sensitive,ultrasoft,and controlled adhesive capabilities prompted great potential of the flexible ionogel in medical diagnosis and wearable electronics.

Temperature-sensitive and solvent-resistance hydrogel sensor for ambulatory signal acquisition in“moist/hot environment”

To realize continuously and stably work in a“moist/hot environment”,flexible electronics with excellent humid resistance,antiswelling,and detection sensitivity are demanding.Herein,a solvent-resistant and temperature-ultrasensitive hydrogel sensor was prepared by combining MXene and quaternized chitosan(QCS)with the binary polymer chain.The strong electrostatic interaction between the QCS chain and the poly(acrylic acid)(PAA)network endows the hydrogel stability against solvent erosion,high temperature,and high humidity.The strong dynamic interaction between MXene and polymer matrix significantly improves the mechanical properties and sensing(strain and temperature)sensitivity of the hydrogel.The hydrogel strain sensor exhibits a high gauge factor(5.53),temperature/humidity tolerance(equilibrium swelling ratio of 2.5%at 80℃),and excellent cycle stability,which could achieve a remote and accurate perception of complex human motion and environment fluctuation under aquatic conditions.Moreover,the hydrogel sensor exhibits impressive thermal response sensitivity(-3.183%/℃),ultrashort response time(<2.53 s),and a low detection limit(<0.5℃)in a wide temperature range,which is applied as an indicator of the body surface and ambient temperature.In short,this study broadens the application scenarios of hydrogels in persistent extreme thermal and wet environments.

Ultralow specific ON-resistance high-k LDMOS with vertical field plate

An ultralow specific on-resistance high-k LDMOS with vertical field plate（VFP HK LDMOS） is proposed. The high-k dielectric trench and highly doped interface N＋ layer are made in bulk silicon to reduce the surface field of the drift region in the VFP HK LDMOS. The gate vertical field plate（VFP） pinning in the high-k dielectric trench can modulate the bulk electric field. The high-k dielectric not only provides polarized charges to assist depletion of the drift region, so that the drift region and high-k trench maintain charge balance adaptively,but also can fully assist in depleting the drift region to increase the drift doping concentration and reshape the electric field to avoid premature breakdown. Compared with the conventional structure, the VFP HK LDMOS has the breakdown voltage of 629.1 V at the drift length of 40 μm and the specific on-resistance of 38.4 mΩ·cm^2 at the gate potential of 15 V. Then the power figure of merit is 10.31 MW/cm^2.

Power scaling on tellurite glass Raman fibre lasers for mid-infrared applications

The power scaling on mid-infrared Raman fibre lasers(RFLs) is in demand for applications in health, environment and security. In this paper, we present the simulated laser behaviours of the tellurite glass RFLs pumped by 300-W Tm-doped fibre lasers(TDFLs) at 2 μm for the first time. By combining the advantages of the TDFLs and tellurite fibre, the output power at 2.35 μm has reached over hundreds of watts by first-order Raman shift. Moreover, the cascaded RFLs have been demonstrated with a wavelength extension greater than 3 μm and output power of tens of watts. To maximize the output power and the slope efficiency of the RFLs, we further analyse the interaction between the Raman gain and cavity loss, which are determined by fibre length and output reflectance of the laser cavity.

Enhancement the Adhesion between Epoxy Coating and Rusted Structural Steel by Tannic Acid Treatment

An eco-friendly rust converter treatment based on tannic acid was optimized by orthogonal experiment, and the adhesion of the epoxy top-coating system was evaluated. The results showed that the adhesion between the epoxy coating and the rusted steel after treatment was enhanced from 1.93 to 5.97 MPa. This adhesion improvement was attributed to the formation of the micro-cracked tannic conversion layer and the increase of the compactness of the rust layer. The failure analysis suggested that the remainder rust was still the key issue for the further adhesion improvement of the coating system.

仿生定向液体输送的功能材料表面设计与应用

无外界能量输入及设备辅助的情况下,在基底表面上控制液体自发输送在微流控和流体低能耗运输中具有重要意义。然而,液体的自发输送会被接触角滞后效应及摩擦阻力所阻碍。自然界中的生物(如蝴蝶翅膀、仙人掌、猪笼草、蜘蛛丝和沙漠甲虫)特殊的表面形貌结构能够将收集到的水分自发输送。受此启发,通过表面调控等方法人工合成材料的仿生表界面也可以自发运输液体。近十余年,仿生表面的液体定向输送得到了广泛关注和深入研究,预期在定向集水、宏观液体输送、油水分离、微流控系统等领域具有广泛的应用前景。本综述系统地介绍了定向运输液体功能材料的原理、合成方法及其应用,深入解析了制约其应用的主要因素,并总结和展望了定向运输液体的功能材料在未来发展中所面对的机遇与挑战。