Summary of main observation and conclusion A total synthesis of 6,7,9,10,12,12o-hexahydro-2-methyl-(2R/4αS,12α5)-2H,5H-benzo[e]pyrrolo-[3,2;l-ij]quinolone-4;ll(1H,3H)-dione(1),a unique pyrroloquinolone-type Lycopodi...Summary of main observation and conclusion A total synthesis of 6,7,9,10,12,12o-hexahydro-2-methyl-(2R/4αS,12α5)-2H,5H-benzo[e]pyrrolo-[3,2;l-ij]quinolone-4;ll(1H,3H)-dione(1),a unique pyrroloquinolone-type Lycopodium alkaloid containing a complex 6/6/6/5 tetracyclic core,has been disclosed in eight steps and 38%overall yield.The reported synthesis features a short,efficient synthesis of the crucial multi-substituted cyclohexanone intermediate with three stereogenic centers,and one-pot generation of the complex 6/6/6/5 tetracyclic core in a single tandem step.展开更多
基金Financial support from the National Natural Science Foundation of China(Nos.21532002,21761142001 and 21778031)the National Key Research and Development Program(No.2018YFCO310900)is greatly appreciateq.
文摘Summary of main observation and conclusion A total synthesis of 6,7,9,10,12,12o-hexahydro-2-methyl-(2R/4αS,12α5)-2H,5H-benzo[e]pyrrolo-[3,2;l-ij]quinolone-4;ll(1H,3H)-dione(1),a unique pyrroloquinolone-type Lycopodium alkaloid containing a complex 6/6/6/5 tetracyclic core,has been disclosed in eight steps and 38%overall yield.The reported synthesis features a short,efficient synthesis of the crucial multi-substituted cyclohexanone intermediate with three stereogenic centers,and one-pot generation of the complex 6/6/6/5 tetracyclic core in a single tandem step.
